Pre-print publication: https://www.researchsquare.com/article/rs-5278391/v1
In collaboration with Mark Cutosky’s lab from the Mechanical Engineering department and building on previous work introducing a durable, soft strain sensor, this research presents VITALS, an implantable strain sensing network that enables continuous biventricular, multiaxial monitoring of cardiac function. The sensor’s novel design affords a longer fatigue life than previously possible for soft, large-deformation strain sensors, while effectively minimizing shear loading effects to enhance accuracy. Additionally, the system integrates a sensor on the aorta for synchronous systolic pressure monitoring. Animal studies conducted by the Ma lab demonstrate VITALS’ ability to track epicardial strain with high fidelity, detect preload changes rapidly, and differentiate inotropic states. Validation against echocardiographic chamber volumes and global longitudinal strain underscores the sensor’s clinical relevance, offering a practical solution for continuous, accurate cardiac monitoring to improve patient outcomes.