Karlsson K, Przybilla M, Xu H, Kotler E, Karagyozova K, Sockell A, Liu K, Mah A, Lo YH, Lu B, Houlahan KE, Khan K, Ma Z, Suarez CJ, Barnes CP, Kuo CJ, Curtis C. Experimental evolution in TP53 deficient human gastric organoids recapitulates tumorigenesisBiorxiv. doi: 10.1101/2022.04.09.487529v2.

LeSavage BL, Gilchrist AE , Krajina BA, Karlsson K, Smith AR , Karagyozova K , Klett KC , Curtis C, Kuo CJ, Heilshorn SJ.  Engineered extracellular matrices reveal stiffness-mediated chemoresistance in patient derived pancreatic cancer organoidsBiorxiv. doi: 10.1101/2022.04.22.488943v1.

Salahudeen AA,  Yuki K,  Seoane JA,  Mah AT,  Smith AR, Kolahi K, De la O SM,  Hart DJ, Ding J, Ma Z, Sammy Barkal S,  Shukla ND, Zhang C, Cantrell MA, Batish A, Usui T, Root D, Hahn W,  Curtis C, Kuo CJ. Pan-cancer organoid validation of tumor outlier chromosomal amplification eventsBiorxiv. doi: 10.1101/2021.10.05.463147v1.

Becker WR, Nevins S, Chen D, Chiu R, Horning H, Laquindanum R, Mills M, Chaib H, Ladabaum U, Longacre T, Shen J, Esplin ED, Kundaje A, Ford JM, Curtis C, Snyder MP, Greenleaf WJ. Single cell analyses reveal a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancerBiorxiv. doi:10.1101/2021.03.24.436532, 2021. in press Nature Genetics.

Raj N, Wang M, Seoane JA, Moonie NA, Demeter J, Kaiser AM, Boutelle AM, Mulligan AS, Moffatt C, Curtis C, Chang HY, Jackson PK, Attardi LD. The Mettl3 epitranscriptomic writer amplifies p53 stress responsesBiorxiv. doi:10.1101/2021.10.21.465324. in press Molecular Cell.


Strand SH, Rivero-Gutiérrez B, Houlahan KE, Seoane JA … Curtis C … Hwang S, West R. DCIS genomic signatures define biology and correlate with clinical outcome: a Human Tumor Atlas Network (HTAN) analysis of TBCRC 038 and RAHBT cohortsBiorxiv. doi:10.1101/2021.06.16.448585.

Salahudeen AA, Yuki K, Seoane JA, Mah AT, Smith AR, Kolahi K, De la O SM, Hart DJ, Ding J, Ma Z, Barkal S, Navika D. Shukla, Zhang Z, Cantrell MA, Batish A, Usui T, Root D, Hahn W, Curtis C, Kuo CJ. Pan-cancer organoid validation of tumor outlier chromosomal amplification eventsBiorxiv. doi:10.1101/2021.10.05.463147.

McNamara K, Caswell-Jin JL, Ma Z, Joshi R, Kotler E, Bean G, Kriner M, Zhou Z, Hoang M, Beechem J, Zoeller J, Press MF, Slamon D, Hurvitz S & Curtis C. Spatial proteomic characterization of HER2-positive breast tumors through neoadjuvant therapy predicts response. Nature Cancer. doi:10.1038/s43018-021-00190-z, 2021.

Caswell-Jin JL, Lorenz C, Curtis C. Molecular heterogeneity and evolution in breast cancer. Annual Reviews in Cancer Biology (5) 2021. doi:10.1146/annurev-cancerbio-060220-014137.

Nederof I, Horlings HM, Curtis C, Kok M. A high-dimensional window into the microenvironment of triple negative breast cancerCancers (Basel) 13(2): E16. doi:10.3390/cancers13020316. PMID: 33467084.

Lo YH, Kolahi KS, Du Y, Chang CY, Krokhotin A, Nair A, Sobba WD, Karlsson K, Jones SJ, Longacre TA, Mah AT, Tercan B, Sockell A, Xu H, Seoane JA, Chen J, Shmulevich I, Weissman JS, Curtis C, Califano A, Fu H, Crabtree GR, Kuo CJ. A CRISPR/Cas9-engineered ARID1A-deficient human gastric cancer organoid model reveals essential and non-essential modes of oncogenic transformation. Cancer Discovery, 2021 Jan 15;candisc.1109.2020. doi:10.1158/2159-8290.CD-20-1109.

Caswell-Jin JL and Curtis C. Androgen receptor agonists as breast cancer therapeuticsNature Medicine, 2021. doi:10.1038/s41591-021-01242-8.

Lo YH, Kolahi KS, Du Y, Chang CY, Krokhotin A, Nair A, Sobba WD, Karlsson K, Jones SJ, Longacre TA, Mah AT, Tercan B, Sockell A, Xu H, Seoane JA, Chen J, Shmulevich I, Weissman JS, Curtis C, Califano A, Fu H, Crabtree GR, Kuo CJ. A CRISPR/Cas9-engineered ARID1A-deficient human gastric cancer organoid model reveals essential and non-essential modes of oncogenic transformation. Cancer Discovery, 2021 Jan 15;candisc.1109.2020. doi:10.1158/2159-8290.CD-20-1109.


Hurvitz S, Caswell-Jin J, McNamara K, Zoeller J, Bean G,  Dichmann R, Perez A, Patel R, Zehngebot L, Allen H, Bosserman L, DiCarlo B, Kennedy A, Giuliano A, Calfa C, Molthrop D, Mani A, Chen HW, Dering J, Adams B, Press M, Brugge J, Curts C†, Slamon D†. Pathologic and molecular responses to neoadjuvant trastuzumab and/or lapatinib from a phase II randomized trial in HER2-positive breast cancer (TRIO-US B07)Nature Communications, 2020. doi:10.1038/s41467-020-19494-2.

Caswell-Jin JL, Lorenz C, Curtis C. Molecular heterogeneity and evolution in breast cancer. Annual Reviews in Cancer Biology, 2020;5. doi:10.1146/annurev-cancerbio-060220-014137.

Bieging-Rolett KT, Kaiser AM, Morgens DW, Boutelle AM, Seoane JA, Van Nostrand EL, Zhu C, Houlihan SL, Mello SS, Yee BA, McClendon J, Pierce SE, Winters IP, Wang M, Connolly AJ, Lowe SW, Curtis C, Yeo GW, Winslow MM, Bassik MC, Attardi LD. Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program. Mol Cell., 2020 Nov 5;80(3):452-469.e9. doi:10.1016/j.molcel.2020.10.022.

Nasa Sinnott-Armstrong, Jose A Seoane, Jonathan K Pritchard,  Christina Curtis, Michael P Snyder. Convergent mutations in tissue-specific regulatory regions reveal novel cancer drivers. Biorxiv. doi:10.1101/2020.08.21.239954.

Zahir N, Sun R, Gallahan D, Gatenby RA, Curtis CCharacterizing the ecological and evolutionary dynamics of cancer. Nat Genet., 2020 Aug;52(8):759-767. doi:10.1038/s41588-020-0668-4. Epub 2020 Jul 27.

Hu Z, Curtis C. Looking backward in time to define the chronology of metastasis. Nat Commun., 2020 Jun 25;11(1):3213. doi:10.1038/s41467-020-16995-y.

Xiao Y, Thakkar KN, Zhao H, Broughton J, Li Y, Seoane JA, Diep AN, Metzner TJ, von Eyben R, Dill DL, Brooks JD, Curtis C, Leppert JT, Ye J, Peehl DM, Giaccia AJ, Sinha S, Rankin EB. The m6A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor. Proc Natl Acad Sci U S A, 2020 Aug 19:202000516. doi:10.1073/pnas.2000516117.

Hu Z, Li Z, Ma Z, Curtis C. Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastasesNature Genetics. doi:10.1038/s41588-020-0628-z, 2020.

Baslan T, Kendall J, Volyanskyy K, McNamara K, Cox H, D’Italia S, Ambrosio F, Riggs M, Rodgers L, Leotta A, Song J , Mao Y, Shah R, Merida RG , Chadalavada K , Gouri Nanjangud, Vinay Varadan , Gordon A, Curtis C,  Krasnitz A , Dimitrova N, Harris L, Wigler M  & Hicks J. Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencingELife e51480. doi:10.7554/eLife.51480, 2020.

Tilk S, Curtis C, Petrov D, McFarland C. Most cancers carry a substantial deleterious load due to Hill-Robertson interferenceBiorxiv. doi:10.1101/764340v2.

Curtis C. Quantifying mutations in healthy bloodScience. doi:10.1126/science.aba989, 2020.

Han K, Pierce S, Li A, Spees K, Anderson G, Seoane JA, Wainberg M, Kostyrko K, Kelly M, Yousefi M, Simpkins S, Yao D, Lee K, Kuo C, Shokat K, Jackson P, Sweet-Cordero A, Kundaje A, Gentles A, Curtis C, Winslow MM, Bassik M.  Genome-wide CRISPR screens in lung cancer spheroids identify 3D growth specific cancer vulnerabilitiesNature. doi:10.1038/s41586-020-2099-x, 2020.

Liu MC, Oxnard GR, Klein EA, Swanton C, Seiden MV on behalf of the CCGA Consortium. Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNAAnnals of Oncology. doi:10.1016/j.annonc.2020.02.011, 2020.

Mao A, Ducker GS, Li Y, Seoane JA, Zhou Y, Liu L, Vanharanta S, Rankin EB, Massagué J, Curtis C, Rabinowitz R, Thompson CB, Ye J. Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Serine and One-Carbon Unit Metabolism. Molecular Cancer Researchdoi:10.1158/1541-7786.MCR-19-0606, 2020.


Seoane JA, Kirkland GR, Caswell-Jin J, Crabtree GR & Curtis C. Chromatin regulators mediate anthracycline sensitivity in breast cancerNature Medicine doi:10.1038/s41591-019-0638-5, 2019

Press releases:
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Stanford news

Hu Z, Ding J, Ma Z, Sun R, Seoane JA, Suarez CJ, Shaffer S, Berghoff AS, Cremolini C, Falcone A, Loupakis, Birner P, Preusser M, Lenz HJ & Curtis C. Quantitative evidence for early metastatic seeding in colorectal cancerNature Genetics doi:10.1038/s41588-019-0423-x, 2019.

On the cover

Press releases:
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Medscape Medical News

Commentary in Cancer DiscoverySeeds of Metastatic Colorectal Cancer are Planted Early in Disease Progression doi: 10.1158/2159-8290.CD-RW2019-097.

Yost KE, Satpathy AT, Wells DK, Qi Y, Wang C, Kageyama R, McNamara K, Granja JM, Sarin KY, Brown RA, Gupta RK, Curtis C, Bucktrout S, Davis MM, Chang ALS, Chang HY. Clonal replacement of tumor-specific T cells following PD-1 blockade.  Nature Medicine doi:10.1038.

Rueda OM, Sammut SJ, Seoane JA, Chin SF, Caswell-Jin J, Ali R, Pereira B, Batra R, Bruna A, Callari M, Provenzano E, Liu B, Wright K, Parisien P, Gillett C, McKinney S, Green AR, Murphy L, Purushotham A, Ellis IO, Pharoah PD, Rueda R, Aparicio S, Caldas C & Curtis C. The dynamics of breast cancer relapse reveal late-recurring ER+ genomic subgroupsNature doi:10.1038/s41586-019-1007-8, 2019.

Press releases:
Stanford Medicine
Yahoo News
Forbes Medicine

Caswell-Jin JL, McNamara K, Reiter JG, Sun R, Hu Z, Ma Z, Ding J, Suarez CJ, Tilk S, Raghavendra A, Forte V, Chin SF, Bardwell H, Provenzano E, Caldas C, Lang J, West R, Tripathy D, Press MF, Curtis C. Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapyNature Communications 10(1):657, 2019.


Corces MR, Granja JM, Shams S, Louie BH, Seoane JA, Zhou W, Silva TC, Groeneveld C, Wong CK, Cho SW, Satpathy AT, Mumbach MR, Hoadley KA, Robertson AG, Sheffield NC, Felau I, Castro MAA, Berman BP, Staudt LM, Zenklusen JC, Laird PW, Curtis C; Cancer Genome Atlas Analysis Network, Greenleaf W & Chang HJ. The Chromatin Accessibility Landscape of Primary Human CancersScience 362(6413) 2018.

Press MF, Seoane JA, Curtis C, Guzman R, Quinaux E, Sauter G, Eiermann W, Mackey JR, Robert N, Pienkowski T, Crown J, Martin M, Valero V, Bee V, Ma Y, Villalobos I, & Slamon DJ. Assessment of HER2 / ERBB2 Status in “HER2 Equivocal” Breast Cancers and the ASCO-CAP Guidelines:  False-Positives due to Heterozygous Deletions of Alternative Control LociJAMA Oncology JAMA Oncoldoi: 10.1001/jamaoncol.2018.6012 2018.

Probert C, Curtis C. A role for chromatin regulatory dynamics in breast cancer evolution. Nature Medicine, News & Views. 24(9):1309-1311, 2018.

Bhatt AS, Curtis C. AGBT meeting reportGenome Biol. 2018 May 21;19(1):60. doi: 10.1186/s13059-018-1447-8.

Pogrebniak K & Curtis C. Harnessing tumor evolution to circumvent resistance. Trends In Genetics, in press.

Calvin Kuo & Curtis C. Organoids reveal cancer dynamics. Nature, News & Views. 556(7702):441-442, 2018.

Afghahi A, Purington N, Han S, Desai M, Pierson E, Mathur M, Seto T, Thompson C, Rigdon J, Telli M, Badve S, Curtis C, West R, Horst K, Gomez G, Ford J, Sledge G & Kurian A. Higher Absolute Lymphocyte Counts Predict Lower Mortality from Early-Stage Triple-Negative Breast Cancer. Clinical Cancer Research, pii: clincanres.1323.2017. doi: 10.1158/1078-0432.CCR-17-1323, 2018.

Rogers ZN, McFarland CD, Winters IP, Seoane JA, Brady JJ, Curtis C, Petrov D & Winslow MM. The fitness landscape of tumor suppression in lung adenocarcinoma in vivo. Nature Genetics 2018 doi:10.1038/s41588-018-0083-2.

Williams MK, Werner B, Curtis C, Barnes CP, Sottoriva S & Graham TA. Quantification of subclonal selection in cancer from bulk sequencing dataNature Genetics, 50(6);895-903 2018.

Cho S, Xu J, Sun R, Mumbach M, Carter AC, Chen YG, Yost KE, Kim J, Nevins S, Chin SF, Carlos Caldas C, Liu JS, Horbeck M, Lim DA, Weissman JS, Curtis C & Chang HY. Promoter of lncRNA gene PVT1 is a tumor suppressor DNA boundary elementCell, 31;173(6):1398-1412.e22, 2018.


Mello SS, Valente LJ, Raj N, Seoane JA, ... , Curtis C, Attardi LD. A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic CancerCancer Cell. 32(4):460-473.e6 2017.

Sun R, Hu Z, Curtis, C. Big Bang tumor dynamics and clonal evolution. In Cancer Evolution. Cold Spring Harbor Perspect Med, Cold Spring Harbor Press. pii: a028381 2017. doi: 10.1101, 2017.

Yan KS, Gevaert O, Zheng GX, Anchang B, Probert CS, ... , Curtis C, Ji HP, Li L, Henning SK, Wong MH & Kuo CJ. Mature enteroendocrine cells possess injury-inducible reserve stem cell function. Cell Stem Cell, 6;21(1):78-90.e6, 2017.

Sun R, Hu Z, Sottoriva A, Graham TA, Harpak A, Ma Z, Shibata D & Curtis C. Between-region genetic divergence reflects the mode and tempo of tumor evolution. Nature Genetics, 2017 doi: 10.1038/ng.3891.

Hu Z, Sun R & Curtis, C. A Population Genetic Perspective on Tumor Evolution. Evolutionary principles – heterogeneity in cancerBiochimica et Biophysica Acta - Reviews on Cancer, pii: S0304-419X(17)30046-X. doi: 10.1016/j.bbcan.2017.03.001, 2017.

Zhao J, Salomon MP, Shibata D, Curtis C, Siegmund K & Marjoram P. Early mutation bursts and cancer stem cell division asymmetry in colorectal tumors. PLoS One, 12(3):e0172516, 2017.

TCGA Research Atlas Network, Seoane JA…Curtis, C...  Integrated genomic characterization of oesophageal carcinoma. Nature Jan, 2017 doi: 10.1038/nature20805.

Gendelman R, Xing H, Mirzoeva OK, Sarde P, Curtis C, Feiler HS, McDonagh P, Gray JW, Khalil I, & Korn MW.. Bayesian network inference modeling identifies TRIB1 as a novel regulator of cell cycle progression and survival in cancer cells. Cancer Research, 2017.


Hu Z, Curtis C. Inferring tumor phylogenies from multi-region sequencing. Cell Syst. 3(1):12-4, 2016. 

Hu Z, Mao JH, Curtis C, Huang G, Kuo WL, Lenburg ME, Gu S, Korkola JE, Ziyad S, Bayani N, Samarajiwa S, Seoane JA, Dan M, Esch A, Feiler HS, Wang NJ, Hardwicke MA, Laquerre S, Jackson J, Wood K, Weber B, Spellman PT, Aparicio S, Wooster R, Caldas C, & Gray JW. Genomic co-amplification up-regulates a mitotic gene network whose activity predicts outcome and response to mitotic protein inhibitors in breast cancer. Breast Cancer Research, 18(1):70, 2016. 


Kang H, Salomon MP, Sottoriva A, Zhao J, Toy M, Press MF, Curtis C, Marjoram P, Siegmund K, Shibata D. Many private mutations originate from the first few divisions of a human colorectal adenoma. J Pathology, 2015.    

Sottoriva A, Kang H, Ma Z, Graham TA, Salomon M, Zhao J, Marjoram P, Siegmund K, Press MF, Shibata D & Curtis C. A Big Bang Model of human colorectal tumor growthNature Genetics, 2015.

** Recommended by Faculty of 1000 Prime

Nature Genetics News and Views Commentary: Big Bang and Context Driven Collapse

Nature Reviews Cancer Research Highlight: Explosive Beginnings

Curtis C. Genomic Profiling of breast cancersCurr Opin Obstet Gynecol, 27(1), 2015.

Piccirillo SGM, Spiteri I, Sottoriva A, Touloumis A, Ber S, Price SJ, Heywood R, Francis NJ, Collins VP, Venkitaraman AR, Curtis C, Marioni JC, Tavaré S & Watts C. Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zoneCancer Res 75(1), 2015. 

Moen Vollan HK, Rueda OM, Chin SF, Curtis C, Turashvili G, Shah SP, Lingjaerde OC, Yuan Y, Ng CK, Dunning MJ, Dicks E, Provenzano E, Sammut S, McKinney S, Ellis IO, Pinder S, Purushotham A, Murphy LC, METABRIC Group, Tavaré S, Brenton JD, Pharoah PD, Børrensen-Dale AL, Aparicio S & Caldas C. A tumor DNA complex-arm aberration index is an independent predictor of survival in breast and ovarian cancerMolecular Oncology9(1), 2015. 


Ali HR, Rueda OM, Chin SF, Curtis C, Dunning M, Aparicio S and Caldas C. Genome-driven integrated classification of breast cancer validated in over 7,500 samplesGenome Biology 15(8), 2014. 



    Yuan, Y, Failmezger H, Rueda OM, Ali R, Gräf S, Schwarz R, Chin SF, Curtis C, Bardwell H, Provenzano E, Aparicio S, Caldas C & Markowetz F. Quantitative image analysis of cellular heterogeneity in breast tumorsScience Translational Medicine, 4(157):157ra143, 2012. 

    Lynch AG, Chin SF, Dunning MJ, Caldas C, Tavaré S & Curtis C. Calling sample mixups in cancer population studiesPLoS One, 7(8): e41815, 2012. 

    Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, Speed D, Lynch AG, Samarajiwa S, Yuan Y, Gräf S, Ha G, Haffari G, Bashashati A, Russell R, McKinney S, METABRIC Group, Langerød A, Green A, Provenzano E, Wishart G, Pinder S, Børrensen-Dale, Brenton JD, Tavaré, Caldas C & Aparicio S. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroupsNature, 486(7403):346-52, 2012. 

    Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y, Turashvili G, Ding J, Tse K, Haffari G, Bashashati A, Prentice LM, Khattra J, Burleigh A, Yap D, Bernard V, McPherson A, Shumansky K, Crisan A, Giuliany R, Heravi-Moussavi A, Rosner J, Lai D, Birol I, Varhol R, Tam A, Dhalla N, Zeng T, Ma K, Chan SK, Griffith M, Moradian A, Cheng SW, Morin GB, Watson P, Gelmon K, Chia S, Chin SF, Curtis C, Rueda OM, Pharoah PD, Damaraju S, Mackey J, Hoon K, Harkins T,Tadigotla V, Sigaroudinia M, Gascard P, Tlsty T, Costello JF, Meyer IM, Eaves CJ, Wasserman WW, Jones S, Huntsman D, Hirst M, Caldas C, Marra MA, Aparicio S. The clonal and mutational evolution spectrum of primary triple-negative breast cancersNature, 486(7403):395-9, 2012. 

    Maia AT, Antoniou AC, O'Reilly M, Samarajiwa S, Dunning M, Kartsonaki C, Chin SF, Curtis C, McGuffog L, Domchek SM, Embrace E, Easton DF, Peock S, Frost D, Evans DG, Eeles R, Izatt L, Adlard J, Eccles D, Gemo G, Sinilnikova OM, Mazoyer S, Stoppa-Lyonnet D, Gauthier-Villars M, Faivre L, Venat-Bouvet L, Delnatte C, Nevanlinna H, Couch FJ, Godwin AK, Caligo MA, Swe-Brca SB, Barkardottir RB, Kconfab K, Chen X, Beesley J, Healey S, Caldas C, Chenevix-Trench G, Ponder BA. Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriersBreast Cancer Res, 18;14(2):R63, 2012. 

2011 & Earlier