Extracellular Matrix Regulation of Vascular Cell Fate and Regeneration: Unraveling the Secrets with Dr. Ngan Huang

by Mary Sheridan Bilbao, PA-C, MPAS
October 25, 2023

On October 24, 2023, the Stanford Cardiovascular Institute (CVI) Frontiers in Cardiovascular Science Seminar had the privilege of hosting a captivating talk by Dr. Ngan Huang, head of the innovative Laboratory of Extracellular Matrix Engineering. The event delved into the intricate world of "Extracellular Matrix Regulation of Vascular Cell Fate and Regeneration," shedding light on groundbreaking research that could revolutionize the treatment of tissue ischemia and injuries.

Dr. Huang's lab delves into the dynamic relationship between cells and their extracellular matrix (ECM) microenvironment, particularly in the context of engineering vascularized tissues to tackle tissue ischemia and injuries.

The presentation kicked off by highlighting the pivotal role the ECM plays in shaping cellular processes. Dr. Huang demonstrated how biochemical, mechanical, and biophysical ECM properties can be manipulated to influence endothelial differentiation, cell survival, angiogenic capacity, and the endothelial-to-mesenchymal transition.

The audience was provided examples, showcasing the tangible impact of tweaking the ECM microenvironment to engineer cell fate and drive vascular regeneration. These real-world applications highlighted the transformative potential of Dr. Huang's research in addressing pressing medical challenges.

The talk underscored the practical applications of ECM manipulation, emphasizing its potential in treating peripheral arterial disease, vascular injuries, and abdominal aortic aneurysms. Dr. Huang's insights opened new avenues for addressing impaired blood flow and the complexities of aortic aneurysms.

In summary, Dr. Ngan Huang's presentation painted a vivid picture of how the ECM microenvironment orchestrates cellular behavior, offering a glimpse into the future of regenerative medicine. This event showcased the Laboratory of Extracellular Matrix Engineering's pioneering work, leaving the audience eager to witness the impactful breakthroughs that may arise from Dr. Huang's cutting-edge research.

View Dr. Huang's full presentation here.

Frontiers seminars take place on Tuesdays from 12–1pm.  In-person and Zoom options are available for all seminars, details for each seminar can be found here, on the CVI Frontiers website.