Publications

1.     O.A.W. Haabeth*, T.R. Blake*, C.J. McKinlay, A.A. Tveita, A. Sallets, R.M. Waymouth, P.A. Wender, and R.Levy. Local Delivery of Ox40l, Cd80, and Cd86 mRNA Kindles Global Anticancer Immunity. Cancer Res, 79 (7): 1624, 2019. PMCID: PMC6445668.

2.     C.J. McKinlay, J.R. Vargas, T.R. Blake, J.W. Hardy, M. Kanada, C.H. Contag, P.A. Wender, R.M. Waymouth. Charge-altering Releasable Transporters (CARTs) for the Delivery and Release of mRNA in Living Animals. Proceedings of the National Academy of Sciences of the United States of America, 114(4): E456, 2019. PMCID: PMC5278438.

3.    O.A.W. Haabeth*, T.R. Blake*, C. McKinlay*, R.M. Waymouth, P.A. Wender, R. Levy. mRNA vaccination with charge-altering releasable transporters elicits human T cell responses and cures established tumors in mice. Proceedings of the National Academy of Sciences of the United States of America, 115(39): E9153-E9161, 2018.

4.     M. Habibian, C. McKinlay, T.R. Blake, A.M. Kietrys, R.M. Waymouth, P.A. Wender, E.T. Kool. Reversible RNA acylation for control of CRISPR-Cas9 gene editing. Chemical Science, 11: 1011-1016, 2020.

5.    T.R. Blake*, W.C. Ho*, C.R. Turlington, X. Zang, M.A. Huttner, P.A. Wender, R.M. Waymouth. Synthesis and mechanistic investigations of pH-responsive cationic poly(aminoester)s. Chemical Science, 11: 2951-2966, 2020. (*, co-first authored).

1.     Z. Chen, M. Chen, K. Zhou, J. Rao*. Pre-targeted imaging of protease activity through in situ assembly of nanoparticles. Angew. Chem. Int. Ed. 2020, 59: 7864-7870.

2.    Z. Chen, M. Chen, Y. Cheng, T. Kowada, J. Xie, X. Zheng, J. Rao*. Exploring the condensation reaction between aromatic nitriles and amino thiols to optimize in situ nanoparticle formation for the imaging of proteases and glycosidases in cells. Angew. Chem. Int. Ed. 2020, 132: 3298-3305.

3.    X. Zheng, L. Cui, M. Chen, L.A. Soto, E.E. Graves, J. Rao*. A near-infrared phosphorescent nanoprobe enables quantitative, longitudinal imaging of tumor hypoxia dynamics during radiotherapy. Cancer research. 2019, 79: 4787-4797.  PMCID: PMC6744984.

1.     V.J. Chen, G. Hernandez-Meza, P. Agrawal, C.A. Zhang, L. Xie, C.L. Gong, C.R. Hoerner, S. Srinivas, E.K. Oermann, A.C. Fan. Time on Therapy for at Least Three Months Correlates with Overall Survival in Metastatic Renal Cell Carcinoma. Cancers, 11(7): 1000, 2019. PMCID: PMC6678132.

1)    Davis RM, Campbell JL, Burkitt S, Qui Z, Kan S, Mehraein M, Miyasato D, Salinas H, Liu JTC, Zavaleta C. A Raman Imaging Approach Using CD47 Antibody-Labeled SERS Nanoparticles for Identifying Breast Cancer and Its Potential to Guide Surgical Resection. 2018. Nanomaterials. 8(11):953. PMCID: PMC6265869.

2)    Arami H, Patel CB, Madsen SJ, Dickinson PJ, Davis RM, Zeng Y, Sturges BK, Woolard KD, Habte FG, Akin D, Sinclair R, Gambhir SS. Nanomedicine for Spontaneous Brain Tumors: A Companion Clinical Trial. ACS Nano, 2019, 13(3): 2858-2869. PMCID: PMC6584029.

3)    Harmsen S, Rogalla S, Huang R, Spaliviero M, Neuschmelting V, Hayakawa Y, Lee Y, Tailor Y, Toledo-Crow R, Kang JW, Samii JM, Karabeber, Davis RM, White JR, van de Rijn M, Gambhir SS, Contag CH, Wang TC, Kircher MF. Detection of Premalignant Gastrointestinal Lesions Using Surface-Enhanced Resonance Raman Scattering-Nanoparticle Endoscopy. ACS Nano, 2019, 13(2): 1354-1364. PMCID: PMC6428194.

1.     S.C. Casey, L. Tong, Y. Li, R. Do, S. Walz, K.N. Fitzgerald, A.M. Gouw, V. Baylot, I. Gutgemann, M. Ellers, D.W. Felsher. MYC regulates the Antitumor Immune Response through CD47 and PD-L1. Science, 352(6282): 227-31,  2016. PMCID: PMC4940030.

2.     L.S. Eberlin, M. Gabay, A.C. Fan, A.M. Gouw, R.J. Tibshirani, D.W. Felsher, R.N. Zare. Alteration of the lipid profile in lymphomas induced by MYC overexpression. Proceedings of the National Academy of Sciences of the United States of America, 111(29): 10450-5, 2014. PMCID: PMC4115527.

3.     A.M. Gouw, G.G. Toal, D.W. Felsher. Metabolic Vulnerabilities of MYC-induced cancer. Oncotarget, 7(21):29879-80, 2016. PMCID: PMC5058649.

4.     E.H. Shroff, L.S. Eberlin, V.M. Dang, A.M. Gouw, M. Gabay, S.J. Adam, D.I. Bellovin, P.T. Tran, W.M. Philbrick, A. Garcia-Ocana, S.C. Casey, Y. Li, C.V. Dang, R.N. Zare, D.W. Felsher. MYC Oncogene Overexpression Drives Renal Cell Carcinoma in a Mouse Model Through Glutamine Metabolism. Proceedings of the National Academy of Sciences of the United States of America, 112(21): 6539-44, 2015. PMCID: PMC4450371.

5.     A. Yetil, B. Anchang, A.M. Gouw, S.J. Adam, T. Zabuawala, R. Parameswaran, J. van Riggelen, S. Plevritis, D.W. Felsher. p19ARF is a Critial Medidator of both Cellular Senescence and an Innate Immune Response Associated with MYC Inactivation in mouse model of acute Leukemia. Oncotarget, 6(6):3563-77, 2015. PMCID: PMC4414137.

6.     H. Miess, B. Dankworth,  A.M. Gouw, M. Rosenfeldt, W. Schmitz, M. Jiang, B. Saunders, M. Howell, J. Downward, D.W. Felsher, B. Peck, A. Schulze. The Glutathione Redox System is Essential to Prevent Ferroptosis caused by Impaired Lipid Metabolism in Clear Cell Renal Cell Carcinoma. Oncogene, 37(40): 5435-50, 2018. PMCID: PMC6173300.

7.     B.J. Altman, A.L. Hsieh, A.M. Gouw, C.V. Dang. Correspondence: Oncogenic MYC Persistently Upregulates the Molecular Clock Component REV-ERB⍺. Nature Communication, 8:14862, 2017. PMCID: PMC5376640.

8.     A.M. Gouw, G. Efe, R. Barakat, A. Preecha, M. Mehdizadeh, S.A. Garan, G.A. Brooks. Roles of Estrogen Receptor-Alpha in Mediating Life Span: The Hypothalamic Deregulation Hypothesis. Physical Genomics, 49(2): 88-95, 2017, PMID: 28011880.

9.     A.M. Gouw, L.S. Eberlin, K. Margulis, D.K. Sullivan, G.G. Toal, L. Tong, R.N. Zare, D.W. Felsher. Oncogene KRAS Activates Fatty Acid Synthase, Resulting in Specific ERK and Lipid Signatures with Lung Adenocarcinoma, Proceedings of the National Academy of Sciences of the United States of America, 114:(17): 4300-4305, 2017. PMCID: PMC5410819.

10.  R.A. Ortiz, S. Witte, A.M. Gouw, A. Sanfilippo, R. Tsai, D. Fumagalli, C. Yu, K. Lant, N. Lipintz, J. Shepphird, F.B. Alvina, J. Cheng-Ho Lin. Engaging a Community for Rare Genetic Disease: Best Practices and Education From Individual Crowdfunding Campaings. Interact J Med Res, 7(1):e3, 2018. PMCID: PMC5818677.

11.  A.M. Gouw. Challenging the Therapy/Enhancement Distinction in CRISPR Gene Editing. Book Chapter in The Palgrave Handbook of Philosophy and Public Policy, pp. 493-508. ed. David Boonin. Palgrave Macmillan, 2018.

12.  A.M. Gouw, K. Margulis, N.S. Liu, S.J. Raman, A. Mancuso, G.G. Toal, L. Tong, A. Mosely, A.L. Hsieh, D.K. Sullivan, Z.E. Stine, B.J. Altman, A. Schulze, C.V. Dang, R.N. Zare, D.W, Felsher. The MYC Oncogene Cooperates with Sterol- Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth. Cell Metabolism, 30(3): 556-72, 2019. PMCID: PMC6911354.

13. B. Das B, B. Pal, R. Bhuyan, H. Li, A. Sarma, S. Gayan, J. Talukdar, S. Sandhya, S. Bhuyan, G. Gogoi, A.M. Gouw, D. Baishya, J. R. Gotlib, A.C. Kataki, D. W. Felsher. MYC Regulates the HIF2α Stemness Pathway via Nanog and Sox2 to Maintain Self-Renewal in Cancer Stem Cells versus Non-Stem Cancer Cells. Cancer Res. 2019;79(16):4015-4025. PMCID: PMC6701948.

1.    R. Khalifehzadeh, H. Arami. The CpG Molecular Structure Controls Mineralization of Calcium. Phosphate Nanoparticles and their Immunostimulation Efficacy as Vaccine Adjuvants. Nanoscale, 12: 9603-15, 2020. PMCID: PMC7239567.

2.    R. Khalifehzadeh, H. Arami. Biodegradable Calcium Phosphate Nanoparticles for Cancer Therapy. Advances in Colloid and Interface Science, 279: 102157, 2020. PMCID: PMC7261203.

3.    R. Khalifehzadeh, H. Arami. DNA-templated strontium-doped calcium phosphate nanoparticles for gene delivery in bone cells. ACS Biomaterials Science & Engineering, 5: 3201-11, 2019. PMCID: PMC6779169.

1.     J. Harmon, F. Kabinejadian, R. Seda, M. Fabiilli, S.P. Kuruvilla, C. Kuo, J. Greve, B. Fowlkes, J. Bull. Minimally invasive gas embolization using acoustic droplet vaporization in a rodent model of hepatocellular carcinoma. 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Honolulu, HI, USA 2018.

2.     T. Worlikar, E. Vlaisavljevich, T. Gerhardson, J. Greve, S. Wan, S. P. Kuruvilla, J. Lundt, K. Ives, T. Hall, T. Welling, F.T. Lee, Jr, Z. Xu. “Histotripsy for non-invasive ablation of hepatocellular carcinoma (HCC) tumor in a subcutaneous xenograft murine model.” 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Honolulu, HI, USA 2018.

1.         E. Ng, A.K. Le, M.H. Nguyen, & S.X. Wang. Early Multiplexed Detection of Cirrhosis using Giant Magnetoresistive Biosensors with Protein Biomarkers. ACS sensors, 5, 3049–3057, 2020.

2.         N. Ravi, D.L. Cortade, E. Ng, & S.X. Wang. Diagnostics for SARS-CoV-2 detection: A comprehensive review of the FDA-EUA COVID-19 testing landscape. Biosens. Bioelectron. 165, 112454, 2020. PMCID: PMC7368663.

1.     Chris Siefe, Randy D Mehlenbacher, Chunte Sam Peng, Yunxiang Zhang, Stefan Fischer, Alice Lay, Claire A McLellan, A Paul Alivisatos, Steven Chu, Jennifer A Dionne. Sub-20 nm Core-Shell-Shell Nanoparticles for Bright Upconversion and Enhanced Forster Resonant Energy Transfer. J. Am. Chem. Soc. 2019, 141, 42, 16997-17005. PMID: 31592655.

1.     C. Mallow, J. Thiboutot, R. Semaan, M.M. Hayes, R. Hales, A. Ram, D. Feller-Kopman, H. Lee, L. Yarmus. External Beam Radiation Therapy Combined with Airway Stenting Leads to Better Survival in Patients with Malignant Airway Obstruction. Respirology, 2018. PMCID: PMC6135707.

2.     L.C. Peng, A.K. Narang, C. Gergis, N.A. Radwa, P. Han, AE. Marciscano, S.P. Robertson, P. He, J. Trieu, A.N. Ram, T.R. McNutt, E. Griffith, T.A. DeWeese, S. Honig, H. Singh, S.C. Greco, P.T. Tran, C. Deville, T.L. DeWeese, D.Y. Song. Effects of perineural invasion on biochemical recurrence and prostate cancer-specific survival in patients treated with definitive external beam radiotherapy. Urolology Oncology, 36(6): 309, 2018. PMID: 29551548.

1.     E.C. Pratt, T.M. Shaffer, Q. Zhang, C.M. Drain, J. Grimm. Nanoparticles as Multimodal Photon Transducers of Ionizing Radiation. Nature Nanotechnology, 13(5):418-426, 2018. PMCID: PMC5973484.

2.     T.M. Shaffer, E.C. Pratt, J. Grimm. Utilizing the power of Cerenkov light with Nanotechnology. Nature Nanotechnology, 12(2): 106-17, 2017. PMCID: PMC5540309.

3.    Y.E. Monfared, T.M. Shaffer, S.S. Gambhir, K.C. Hewitt. Continuous-wave coherent Raman spectroscopy via plasmonic enhancement. Scientific Report, 9: 12092, 2019. PMCID: PMC6702195.

4.    T.M. Shaffer, S.S. Gambhir, A. Aalipour, C. Schurch. PET imaging of the natural killer cell activation receptor NKp30. Journal of Nuclear Medicine, 61(9): 1348-1354, 2020. PMCID: PMC7456168.

5.    A. Aalipour, F. Le Boeuf, M. Tang, S. Murty, F. Simonetta, A.X. Lozano, T.M. Shaffer, J.C. Bell, S.S. Gambhir. Viral delivery of CAR targets to solid tumors enable effective cell therapy. Molecular Therapy: Oncolytics, 17: 232-240, 2020. PMCID: PMC7183102.

6.    S. Murty, S.T. Haile, C. Beinat, A. Aalipour, I.S. Alam, T. Murty, T.M. Shaffer, C.B. Patel, E.E. Graves, C.L. Mackall, S.S. Gambhir. Intravital imaging reveals synergistic effect of CAR T-cells and radiation therapy in a preclinical immunocompetent glioblastoma model. OncoImmunology, 9:(1): 1757360, 2020. PMCID:  PMC7458609.

7.    T. Shaffer, S. Gambhir. Multiplexed Raman imaging in tissues and living organisms. Methods in Molecular Biology, Ed: E. Zamir, 2020. (Book chapter)

8.    I. Alam, T. Shaffer, S. Gambhir. Nuclear imaging of endogenous markers of lymphocyte response. Nuclear imaging and immunology, Ed: Abbas Alavi, 2020. (Book chapter)