Early Critical Care Research

Fellows Research

Sladen RN, Rosenthal MH: Specific afterload reduction with parenteral hydralazine following cardiac surgery. J Thoracic and Cardiovascular Surgery 78:195-202, 1979.
Mihm FG, Feeley TW, Rosenthal MH, Raffin TA: The lack of effect of variable blood withdrawal rates on the measurement of mixed venous oxygen saturation. Chest 78:452-455, Sept 1980.
Stanski DR, Mihm FG, Rosenthal MH, Kalman SM: Pharmacokinetics of high dose thiopental used in cerebral resuscitation. Anes 53(2):169-171, Aug 1980.
Mihm FG, Feeley TW, Rosenthal MH, Lewis F: Measurement of extravascular lung water in dogs using the thermal-green dye indicator dilution method. Anes 57:116-122, Aug 1982.
Saul GM, Feeley TW, Mihm FG: The effect of graded administration of positive end-expiratory pressure on lung water in non-cardiogenic pulmonary edema. Crit Care Med 10(10):667-669, Oct 1982.
Pearl RG, Rosenthal MH, and Ashton JPA: Pulmonary vasodilator effects of nitroglycerin and nitroprusside in canine oleic acid-induced pulmonary hypertension. Anes 58:514-518, 1983.
Pearl RG, Rosenthal MH, Schroeder JS, and Ashton JPA: Acute hemodynamic effects of nitroglycerin in pulmonary hypertension. Annals of Internal Medicine 99:9-13, 1983.
Pearl RG, Raffin TA. Niacin reduces oxygen toxicity in mouse alveolar macrophages. Pharmacology 27:219-222, 1983.
Pearl FG, Rosenthal MH, Murad F, Ashton JPA: Aminophylline potentiates sodium nitroprusside - induced hypotension in the dog. Anes 61:712-715, 1984.
Wagner RL, White PF, Kan PB, Rosenthal MH, Feldman D: Inhibition of adrenal steroidogenesis by the anesthetic etomidate. NEJM 310:1415-1421, 1984.
Wagner RL, White PF: Etomidate inhibits adrenocortical function in surgical patients. Anesthesiology 61:647-651, 1984.
Wagner RL, White PF: Etomidate vs. thiopental--Comparative effects on adrenocortical function. Anesthesiology 61:A353, 1984.
Halperin BD, Feeley TW: The effect of anesthesia and surgery on renal function. Int Anesth Clin 22:1,157-168, 1984.
Mihm FG, Halperin BD: Noninvasive detection of profound arterial desaturations using a pulse oximetry device. Anes 62:85-87, 1985.
Halperin BD, Feeley TW, Mihm FG, Chiles C, Guthaner DF, Blank NE: Evaluation of the portable chest roentgenogram for quantitating extravascular lung water in critically ill adults. Chest 88:649-652, 1985.
Feeley TW, Mihm FG, Halperin BD, Rosenthal MH: Failure of colloid oncotic pulmonary artery wedge pressure gradient to predict changes in extravascular lung water. Crit Care Med 13:1025-1028, 1985.
Shapiro JM, White PF, Westphal LM, Sladen RN, Rosenthal MH: Midazolam infusion for sedation in the intensive care unit -effect on adrenal function. Anes 64:394-398, 1986.
Pearl RG, Rosenthal MH, Nielson L. Ashton JPA, Brown BW Jr. Effect of injectate volume and temperature on thermodilution cardiac output determination. Anesthesiology 64:798-801, 1986.
Calcagni D, Mihm FG, Feeley TW, Rosenthal MH, Halperin BD: Thermal-dye method of lung water measurement is reliable at a low cardiac output. J Surg Res 41:286-292, 1986.
Brockman DC, Stevens JH, O’Hanley F, Walker C, Shapiro J, Mihm FG, Collins FA, Raffin TA: Prostaglandin in E 1 does not prevent the adult respiratory distress syndrome in septic primates. Amer Rev Resp Dis 134:885-890, 1986.
Stevens JH, O'Hanley P, Shapiro J, Mihm FG, Satoch PS, Collins JA, Raffin TA: The effects of anti-C5 a antibodies on the adult respiratory distress syndrome in septic primates. J Clinical Investigation 77:1812-1816, 1986.
Brockmann DC, Stevens JH, O'Hanley F, Walker C, Shapiro J, Mihm FG, Collins JA, Raffin TA: Prostaglandin E 1 does not prevent the adult respiratory distress syndrome in septic primates. Amer Rev Resp Dis 134:885-890, 1986.
Rizk NW, Duncan SR, Raffin TA. Problem patient series: Lymphangit carcuninatisus, isoutak Oractuce 21:103, 1986.
Duncan SR, Rizk NW, Raffin TA. Problem patient series: Eosinophilic pneumonia. Hospital Practice 22(2):226-8 Feb 15., 1987.
Westphal LM, Cheng EY, White PF, Sladen RN, Rosenthal MH: Pharmacokinetics and pharmacodynamics of a midazolam infusion following cardiac surgery. Anesthesiology 67:257-262, 1987.<
Duncan SR, Negrin RS, Mihm FG, Gilleminault C, Raffin TA: Nasal CPAP therapy for refractory atelectasis. Chest 92:621-624, 1987.
Duncan SR, Rizk NW, Lombard C. Transbronchial biopsies for the diagnosis of Wegener’s granulomatosis. Chest 92:115, 1987.
Shapiro JM, Mihm FG, Trudell JR, Stevens JH, Feeley TW: Leukotriene D 4 increases extravascular lung water in the dog. Circ Shock 21:121-128, 1987.
Smith DW, Walker JG, Mihm FG, Meredith KS, Frankel LR, Cheng EY, Ariagno RL: Rapid determination of changes in alveolar ventilation during high frequency ventilation. Pediatric Pulmonology 3:406-412, 1987.
Rizk NW, Duncan S, Raffin TA. Problem patient series. Bronchiolitis obliterans organizing pneumonia. Hospital Practices (Office Edition), 22(3):25-29, March 15, 1987.
Rizk NW, Duncan S. Raffin TA. Problem patient series: Pulmonary sequestration. in Hospital Practice (Office Edition), 22(6);70,72. June 15, 1987.
Duncan SR, Rizk NW, Raffin TA. Inverse ratio ventilation: PEEP in disguise? Chest 92:390, 1987.
Duncan SR, Rizk NW, Raffin TA. Problem patient series: Wegener’s granulomatosis in Hospital Practice (Office Edition), 22(3A):82-83, 86, 88. 1998
Pearl RG, Halperin BD, Mihm FG, Rosenthal MH: Pulmonary effects of crystalloid a colloid resuscitation from hemorrhagic shock in the presence of oleic acid-induced pulmonary capillary injury in the dog. Anes 68:12-20, 1988.
Pearl RG, McLean RF, and Rosenthal MH: Effects of spinal anesthesia on the response to main pulmonary artery distention. J Applied Phys 64:742-747, 1988.
Prielipp RC, Rosenthal MH, and Pearl RG: Vasodilator therapy in a vasoconstrictor model of pulmonary hypertension in sheep. Anes 68:552-558, 1988.
Ishizaka A, Harada H, Stephens KE, Wu Z, Hatherill JR, Mallick A, Seagall GM, Lilly CM, O'Hanley PT, Raffin TA. "Preventative effects of pentoxifylline on E. coli induced acute lung injury and multi-organ damage in guinea pigs." In: Mandell GL, Novick WJ, eds. Pentoxifylline and Leukocyte Function. New York: Hoechst-Roussel Inc, Haber & Flora, 1988.
Dunn CJ, Chan J, Rizk NW, Duncan S. Diangosis of pneumonia in heart transplant recipients using fiberoptic bronchoscopy. Chest 94(1): 39S, 1988
Feeley TW, Keating D, Nishimura T: Independent lung ventilation using high frequency ventilation in the management of bronchopleural fistula. Anesthesiology 69:420-422, 1988.
Prielipp RC, Rosenthal MH, Pearl RG: Hemodynamic profiles of prostaglandin E 1, isoproterenol, prostacyclin and nifedipine in vasoconstrictor pulmonary hypertension in sheep. Anes/Anal 67(8):722-729, 1988.
Lilly CM, Sandhu JS, Ishizaka A, Harada H, Yonemaru M, Shi TX, O'Hanley PT, Raffin TA: Pentoxifylline prevents TNF-induced acute lung injury. Am Rev Respir Dis. 139:1361-1368, 1989.
Harada H, Ishizaka A, Mallick AA, Hatherill JR, Zheng H, Lilly CM, O'Hanley PT, Raffin TA: The effects of aminophylline and pentoxifylline on multiple organ damage after E. coli sepsis. Am Rev Respir Dis 140:974-980, 1989.
Turnquist P, Rosenthal MH: Renal insufficiency in the trauma patients. Sem in Anes 8:338-346, 1989.
Finn J, Rosenthal MH: Pulmonary edema in the trauma patient. Sem in Anes 8:265-274, 1989.
Mihm FG, Popovic BK, Noe C, Reitz BA, Hilberman M: Recovery of Cardiopulmonary reflexes in heart-lung transplanted monkeys. J Thor Cardiovasc Surg 98:510-516, 1989.
Machado C, Mihm FG, Noe C: Diagnosis of a ventricular septal defect in an gorilla using in vivo oximetry. J Zoo Animal Medicine 20(2):199-202, 1989.
Siegel LC, Pearl RG, Shafer SL, Ream AK, Prielipp RC: The longitudinal distribution of pulmonary vascular resistance during unilateral hypoxia. Anesthesiology 70:527-532, 1989.
Lilly CM, Ishizaka A, Raffin TA: The measurement of lung water. J Crit Care Med 5:252-264, 1990.
Mihm FG, Sandhu JS, Brown MD, Rosenthal MH: Short-acting beta adrenergic blockade in pheochromocytoma. Crit Care Med 18:673-674, 1990.
McLean RF, Prielipp RC, Rosenthal MH, Pearl RG: Vasodilator therapy in microembolic porcine pulmonary hypertension. Anes/Anal 71:35-41, 1990.
Kraft SA, Larson CP, Shuer LM, Steinberg GK, Benson GV and Pearl RG. Effect of hyperglycemia on neuronal changes in a rabbit model of focal cerebral ischemia. Stroke 21:447-450, 1990.
Pearl RG, Finn JC: Hemodynamic effects of diltiazem during vasoconstrictor pulmonary hypertension in sheep. Anesthesia and Analgesia 71:493-497, 1990.
McGuire GP, Pearl RG: Sepsis and the trauma patient. Critical Care Clinics 6:121-146, 1990.
Cook DJ, Duncan SR. Pulmonary CMV infection in heart transplant recipients. Chest 98:98, 1990.
Cook DJ, Guyatt G, Laine LA, Raffin TA. Nosocomial pneumonia an the role of gastric pH. Chest 98:1, 1990.
Cook DJ, Witt LG, Cook RJ, Guyatt GH. Stress ulcer prophylaxis in the critically ill. Journal of Clinical and Investigative Medicine 13:B22, 1990.
Cook DJ, Chan J, Dunn CJ, Bergen CJ, Duncan SR. Late occurring pneumonia in heart transplant recipients. American Review of Respiratory Diseases 141(4):A604, 1990.
Duncan SR, Rizk NW, Lombard C. The diagnosis of Wegener’s granulomatosis from transbronchial biopsy specimens. Human Path 21(8), 838-41. 1990.
Wakerlin G, Flavin T, Siegel LC, Benson GV, Pearl RG. Pulmonary capillary pressure measurement from pulmonary artery pressure profile analysis. (Submitted to Journal of Clinical Investigation).
Cook DJ, Guyatt GH, Reeve BK, McIlroy W, Pearl RG. The predictive value of serum cortisol in septic shock. Journal of Intensive Care Medicine (in press).
Cook DJ, Witt LG, Cook RJ, Guyatt GH. Stress ulcer bleeding in the critically ill - a meta-analysis. American Journal of Medicine 91(5):519-27, 1991.
Duncan SR, Cook DJ, Chan J. Survival of Gancyclovir treated heart transplant recipients with CMV pneumonitis. Transplantation 52(5):910-913, 1991.
Cook DJ, Pearl RG, Cook RJ, Guyatt GH. The incidence of clinical important bleeding in mechanically ventilated patients. Journal of Intensive Care Medicine 6:167-174, 1991.
Cook DJ, Laine LA, Guyatt GH, Raffin T: Nosocomial pneumonia: the role of gastric pH. Chest 100:7-13, 1991.
Cook DJ, Guyatt GH, Reeve BK, McIlroy W, Pearl RG: Serum cortisol - a predictor of mortality in sepsis? Royal Colleg of Physicians and Surgeons, Quebec City, September 1991. Journal of Clinical Investigative Medicine 14(4):A132, 1991.
Cook DJ, Guyatt GH, Reeve BK, McIlroy W, Pearl RG. Serum cortisol - a predictor of mortality in sepsis. American Review of Respiratory Diseases 143(4)A474, 1991.
Fujishima S, Daniel D, Kim Y, et al: LPS-Induced IL-8/NAP-1 gene induction in human peripheral gromulocytes. Am Rev Resp Dis 143:A512, 1991.
Prielipp RC, Mclean R, Rosenthal MH, Pearl RG: Hemodynamic profiles of prostaglandin E 1, isoproterenol, prostacyclin and nifedipine in experimental porcine pulmonary hypertension. CCM 19:60-67, 1991.
Prielipp RC, McLean R, Rosenthal MH, Pearl RG. Hemodynamic profiles of prostaglandin E 1, isoproterinol, prostacyclin, and nifedipine in experimental porcine pulmonary hypertension. Critical Care Medicine 19:60-67, 1991.
Pearl RG, Prielipp RC. Leukotriene synthesis inhibition and receptor blockade do not inhibit hypoxic pulmonary vasoconstriction in sheep. Anesthesia and Analgesia 72:169-176, 1991.
Fujishima S, Kraft SA, McGuire GP, Raffin T, and Pearl RG. Isoproterenol prevents oxidant-induced injury in isolated rabbit lungs. Pharmacology 43:78-83, 1991
Wakerlin G, Benson GV, Pearl RG: A thromboxane analog increases pulmonary capillary pressure but not permeability in the perfused rabbit lung. Anesthesiology 75:475-480, 1991.
Cook DJ, Laine LA, Salena BJ, Guyatt GH. Endoscopic therapy for non-variceal acute upper gastrointestinal bleeding: A meta-analysis. Gastroenterology 102(1):139-48, 1992.
Gan SC, Barr J, Arieff AL, Pearl RG. Biguanide-associated lactic acidosis. Archives of Internal Medicine, 152:2333-2336, 1992.
Deem S, Rosenthal MH: Adult respiratory distress syndrome. Curr Opinion in Anes 5:866-872, 1992
Pearl RG, Baer ER, Siegel LC, Benson GV, Rice SA. The longitudinal distribution of pulmonary vascular resistance after endotoxin administration in sheep. Critical Care Medicine 20:119-125, 1992
Schwartz GG, Steinman S, Garcia J, Greyson C, Massie B, Weiner MW: Energetics of Acute Pressure Overload of the Porcine Right Ventricle: In Vivo 31P NMR Spectroscopy. Journal of Clinical Investigation (In Press) 1992.
Isaacs, R. Management of thyroid papillary carcinoma with radio iodine in a patient with ESRD on dialysis - (In Press) 1992.
Haddow GR, Riley E, Isaacs R, McSharry R: Ketorolac, nasal polyposis and asthma - A Cause for Concern. Anes and Analg 76:420-2, 1993.
Lindeborg DM, Pearl RG: Inotropic therapy in the critically ill patient. Int Anesth Clinics 31(2):1993.
Mouchawar A, Rosenthal M: A pathophysiological approach to the patient in shock. Int Anes Clinics 31(2):1993
Mei CT, Feeley TW: Coagulopathies and the intensive care setting. Int Anes Clinics 31(2):1993.
Kandra TG, Rosenthal M: The pathophysiology of respiratory failure. Int Anes Clinics 31(2):1993.
Lindeborg DM, Pearl RG. Isotropic therapy in the critically ill patient. International Anesthesiology Clinics 31:49-71, 1993
McConnell MS, Finn JC, Feeley TW: Tension hydrothorax during laparoscopy in a patient with ascites. Anesthesiology 80:1390-923, 1994.
Thompson JS, Pearl RG. Sepsis, Part I: Pathogenesis of septic sock. Seminars in Anesthesia 13:177194, 1994.
Thompson JS, Pearl RG, Sepsis, Part II: Medical management of septic shock.. Seminars in Anesthesia 13:195-203, 1994
Kavanagh BP, Mouchawar A, Goldsmith J, Pearl RG. Effects of inhaled NO and inhibition of endogenous NO synthesis in oxidant-induced acute lung injury. Journal of Applied Physiology 76:1324-1329, 1994.
Mouchawar AM, Kavanagh BP, van Meurs K, Pearl RG. Inhaled nitric oxide does not alter the longitudinal distribution of pulmonary vascular resistance. Journal of Applied Physiology 78:341-348, 1995.
Kraft SA, Fujishima S, McGuire GP, Thompson JS, Raffin TA and Pearl RG. Effect of blood and albumin on pulmonary hypertension and edema in perfused rabbit lungs. Journal of Applied Physiology 78:499-504, 1995.
Wakerlin GE, Finn JC, Siegel LC, Benson GV, Flavin TG, Pearl RG. Pulmonary capillary pressure measurement from pulmonary artery occlusion pressure decay profile analysis in sheep. Anesthesia and Analgesia 81:17-23, 1995.
Kavanagh BP, Pearl RGT. Inhaled nitric oxide in anesthesia and critical care medicine. International Anesthesiology Clinics 33:181-210, 1995.
Tung A, Rosenthal M: Patients requiring sedation. Crit Care Clin 11:791-802, 1995
Levin B, Rosenthal MH: Mechanical ventilation. Ballieres Clin Anes 10:155-180, 1996.
Goldsmith JA, Kavanagh BP, Pearl RG: Plasma potentiates the priming effects of endotoxin on platelet activating factor-induced pulmonary hypertension in the rabbit lung. Anesthesia and Analgesia 83:242-246. 1996.
Kavanagh BP, Thompson JS, Pearl RG: Inhibition of endogenous nitric oxide synthase potentiates nitrovasodilators in experimental pulmonary hypertension. Anesthesiology 85:860-866, 1996.
Traylor RJ, Pearl RG. Crystalloid vs. colloid: all colloids are not created equal. Anesthesia and Analgesia 83:209-221, 1996
Thompson JS, Kavanagh BP, Pearl RG: Nitroglycerin does not alter pulmonary vascular permeability in isolated rabbit lungs. Anesthesia and Analgesia 84:359-361, 1997.
gosselin MV, Rubin GD, leung AN, Huang J, Rizk NW. Unsuspected pulmonary embolism: Prospective detection on routine helical CT scans. Radiology 208:209-215, 1998.
Deb B, Pearl RG: Mechanical ventilation and adjuncts in acute respiratory distress syndrome. International Anesthesiology Clinics 35:109-24, 1997.
Rodriguez RM, Wang NE, Pearl RG: Prediction of poor outcome of intensive care unit patients admitted from the emergency department. Critical Care Medicine 25:1801-6, 1997.
Hill L, Bertaccini E, Barr J, Geller E. ICU sedation: A review of its pharmacology and assessment. J Intensive Care Med 13:174-183, 1998.
Rodriguez RM, Pearl RG: Pulmonary hypertension and major surgery. Anesthesia and Analgesia 87:812-815, 1998.
Aranda M, Mihm FG, Garrett S, Mihm MN, Pearl RG: Continuous cardiac output catheters: Delay in in vitro response time after controlled flow changes. Anesthesiology 89:1592-1595, 1998.
Huang JH, Oefner PJ, Adi V, Ratnam K, Ruoss SJ, Kao PN. Analyses of the NRAMP1 and IFN-R1 genes in women with mycobacterium avium-intracellulare pulmonary disease. Am. J. Resp. Crit. Care Med. 157:377-381, 1998.
Beck CE, Rizk NW, Kiger LT, Spencer D, Hill L, Adler JR. Intracranial hypotension presenting with severe encephalopathy. J Neurosurg 89(3):470-473, 1998.
Trudell J, Bertaccini E. Evaluation of forcefields for molecular mechanics/dynamics calculations involving halogenated anesthetics. Toxicology Letters 100-101:413-419, 1998.
Hill L, Bertaccini E. The pharmacology of ICU sedation: A review. Journal of Intensive Care Medicine 13(4):174-183, 1998.
Huang JH, Kao PN, Adi V, Ruoss SJ. Mycobacterium avium-intracellulare pulmonary infection in HIV negative patients without preexisting lung disease: Diagnostic and management limitations. Chest 155(4):1033-1040, 1999.
Patterson KW, Deb B, Kavanagh BP, Pearl RG. Inhaled nitric oxide potentiates the action of adenosine but not of sodium nitroprusside in experimental pulmonary hypertension. Pharmacology 58:246-251, 1999.
Aranda M, Pearl RG. The biology of nitric oxide. Respiratory Care 44:156-168, 1999.
Aranda M, Bradford KK, Pearl RG. Combined therapy with inhaled nitric oxide and intravenous vasodilators during acute and chronic experimental pulmonary hypertension. Anesthesia and analgesia 89:152-158, 1999.
Hill LL, Pearl RG. Combined inhaled nitric oxide and inhaled prostacyclin during experimental chrohnic pulmonary hypertension. Journal of Applied Phys9iology 86:1160-1164, 1999.
Fowler RA, Cheung Am, Marshall JC. Selective doeconamination of the digestive tract in critically ill patients. Intensive Care Med 25(11): 1323-1326, 1999
Fowler R, Lee C, Keystone J. The role of corticostetoids in the treatment of cerebral schistosomiasis caused by Schistosoma mansoni: case report and discussion. Am J Trop Med Hyg 61:47-50, 1999.
Price JA, Rizk NW. Postoperative ventilatory management. ?Chest 115(5):130S-137S, 1999.
Corwin HL, Gettinger A, Rodrigeuz RM, Pearl RG, Gubler D, Enny C, Colton T, Corwin MJ. Efficacy of recombinant human erythropoietin in the critically ill patient: a randomized double-blind placebo controlled trial. Critical Care Medicine 27:2346-2350, 1999.
Nagamine J, Hill LL, Pearl RG. Combined therapy with zaprinast and inhaled nitric oxide abolishes hypoxic pulmonary hypertension. Critical Care Medicine (in press).
Wall MH, Patterson KW, Kavanagh BP, Pearl RG: Inhibition of endogenous nitric oxide synthesis potentiates the effects of sodium nitroprusside but not of adenosine in experimental pulmonary hypertension.Pharmacology 58:34-43, 1999.
Liepert D, Rosenthal MH, Thomas SJ. Shock: A comparative physiologic approach to mechanisms and management. Sem in Anesth 18:1-14, 1999.
Doss M, Barr J, Bertaccini E, Geller E. The EEG effects of propofol for sedation in ICU patients. Journal of Clinical Pharmacology (in press).
Deb B, Bradford K, Pearl RG. Additive effects of inhaled nitric oxide and intravenous milrinone in experimental pulmonary hypertension. Critical Care Medicine 28:795-799, 2000
Sarinas PS, Chitkara RK, Kuschner WG, Traylor R, Segall GM, Atwood JE. PET and pericardial malignancy (submitted to circulation)
Cartwright DR, Hill LL. Anesthesia for insertion of automatic implantable cardioverter defibrillators. Submitted to Seminars in Cardiothoracic and Vascular Anesthesia, 2000.
Mirza I, Barr J. Bilateral tension pneumothroaces following removal of a mediastinal tube. Critical Care Medicine (case report-in preparation ) 2000.
Kharrazi B, Rizk NW. Use of graphic interfaces in selection of mechanical ventilation parameters (in preparation) 2000.
Angelotti T, Krishna G, Scott J, Weinacker AB. Nodular invasive tracheobronchitis due to aspergillus in a patient with systemic lupus erythematosus. (submitted )2000.
Hecht M, Rizk NW. Blastomycosis and HIV infection (in preparation), 2000.Fowler R, Stewart T. Canadian experience of the international study of mechanical ventilation, (manuscript in preparation ) 2001
Seybold J, Fowler RA, Mihm FR. Histology-proven myocardial injury in Addison’s disease: Possible reversible catecholamine-induced damage to the heart. (Submitted to Chest, March) 2001.
Fowler RA, Pearl RG. The airway: Emergent management for the nonn-anesthesiologist. WJM. Accepted for publication. June, 2001.
Fowler RA, Imrie K. Thalidomide-associated hepatitis,. Am J Hematol 66:300-302, 2001
Kharrzi B, Rizk NW. Use of graphic interfaces in selection of mechanical ventilation parameters (in preparation) 2001.
Hecht M, Rizk NW. Blastomycosis and HIV infection. (in preparation) 2001.

Kraft SA, Mihm FG, Feeley TW. Postoperative Endocrine Problems. In: Post Anesthesia Care. Ed. Vender JS, Spiess BD. WB Saunders, Philadelphia, PA, 1992, pp 216-232.
Cook DJ, Pearl RG. Pharmacology in the Intensive Care Unit. In: Basic Principles in Therapeutics. Ed. Melmon KL, Morrelli HF, Hoffman B, Nierenberg DW. Macmillian Publishing Company, 1992, pp 738-762.
Cook DJ, Raffin TA. Acute Hypoxemic Respiratory Failure. In: Pathophysiologic Foundations of Critical Care Medicine. Ed. Pinsky MR, Dhainaut JF. Williams and Wilkins publishing, 1992
Deb B, Pearl RG (eds.) Advances in Mechanical Ventilation. International Anesthesiology Clinics. Boston: Little, Brown and Company, 1997.
Aranda M, Pearl RG. The Pharmacology and Physiology of Nitric Oxide: Understanding Its Use in Anesthesia and Critical Care. Anesthesiology Clinics of North America, 16:235-257, 1998.
Liepert DJ, Pearl RG. Critical Care Pharmacotherapy. In: Melmon KL, Morrelli HF, Hoffman BB, Nierenberg DW (eds.) Clinical Pharmacology: Basic Principles in Therapeutics (3 rd edition). New York: McMillan (in press).
Liepert DJ, Pearl RG. Fluid Therapy in Intensive Care. Anesthesiology Clinics of North America (in press).
Cook DJ, Raffin TA. Stress ulcer prophylaxis in the 1990's. In: Pathophysiologic Foundations of Critical Care Medicine. Ed. Pinsky MR, Dhainaut JF. Williams and Wilkins publishing, 1992.
Cook DJ, Raffin TA. Withholding and withdrawing life support. In: Current Pulmonology. Eds. Simmons DH, Tierney DF. Mosby Year Book Medical Publishing, 1992.
Kraft S, Feeley T, Mihm F: Postoperative endocrine problems. In: Acute Postoperative Care. Ed. Vender J, Speiss B. W. B. Saunders, Philadelphia, PA, 1992.
McGuire P, Pearl RG. Sepsis. In:. Textbook of Trauma Anesthesia and Critical Care, edition 1. Ed. Grande CM. St. Louis, Missouri: Mosby-Year Book, Inc., 1993, pp 121-146.
Kramer B, Hackel A, Pearl RG. Critical Care Transport (Scene Evacuation). In: Textbook of Trauma, Anesthesia and Critical Care, edition 12. Ed. Grande CM. St. Louis, Missouri: Mosby-Year Book, Inc., 1993, pp 319-324.
Kavanagh BP, Pearl RG. Clinical uses of prostaglandins in anaesthesia and intensive care medicine. In:. Vasoactive Drugs-Baillière’s Clinical Anesthesiology. Ed. Skarvan K. London, England: W.B. Saunders Company, 1994, pp 175-200.
Kavanagh BP, Pearl RG. Pulmonary Effects of Anesthesia. In: Anesthetic Toxicity. Eds. Rice SA, and Fish KJ. New York, New York: Raven Press, 1994, pp 267-280.
Deem S, Pearl RG, Freiha FS. Urology. In: Anesthesiologist’s Manual of Surgical Procedures. Eds. Jaffe RA, and Samuels SI. New York, New York: Raven Press, 1994, pp 547-581.
Wall MH Pearl RG. Postoperative critical care management of the orthopedic trauma patient. In: Problems in Anesthesia. Eds. Rosenberg AD, Bernstein RL. Philadelphia, PA: J.B. Lippincott Company, 1994, pp 445-457.
Kavanagh BP, Pearl RG. Inhaled nitric oxide in anesthesia and critical care medicine. In: Techniques in Bedside Hemodynamic Monitoring. International Anesthesiology Clinics. Eds. Feeley TW, Royston D Boston, MA: Little, Brown and Company, 1995, 33:181-210.
Feeley TW, Botz GH: Factors influencing choice of anesthetic technique. In: Ambulatory Anesthesia and Surgery. Ed. White PRF. W.B. Saunders, Philadelphia, PA, 1997.
Deb B, Feeley TW: Multisystem organ failure - lung dysfunction. In: Essence of Anesthesia Practice. Ed. Roizen MF, Fleisher LA. W. B. Saunders, Philadelphia, PA, 1997.
Wall M, Feeley TW: Anesthesia for patients with cardiac conduction defects. In: Handbook of Clinical Anesthesia. Ed. Goldstone J, Pollard B. Churchill-Livingstone, London, England, 1997.
Rodriguez R, Rosenthal MH: Shock. In Critical Care Medicine - Perioperative Management. Eds. Murray M, Coursin D, Pearl R, Prough D. Lippincott-Raven, Philadelphia, PA, 1997.
Hill L, Bertaccini E, Barr J, Geller E. The Pharmacology of ICU Sedation: A Review. In Journal of Intensive Care Medicihne, 13(4):174-83, 1998.
Aranda M, Pearl RG. Pharmacology and physiology of nitric oxide. International Anesthesiology Clinics, 1997 (in press).
Takhar S, Rosenthal MH. Shock. In O’Donnell, Nacl, Thompson: Surgical Intensive Care Medicine Handbook. Kluwer Academic Publishers (in press) 2001.
Rodriguez R, Rosenthal MH: Shock. In Critical Care Medicine - Perioperative Management, 2 nd Edition. Eds. Murray M, Coursin D, Pearl R, Prough D. Lippincott-Raven, Philadelphia , PA , (in press) 2001.

Rosenthal MH and Sladen RN: Mean arterial pressure: A misleading indicator of after load with sodium nitroprusside therapy. ASA Abstracts, 1978.
Sladen RN and Rosenthal MH: Selective afterload reduction with parenteral hydralazine, ASA abstracts, 1978.
Mihm FG, Feeley TW, Rosenthal MH, Raffin TA: Blood withdrawal rate effect on venous saturations. Anesth 51:S198, Sept 1979.
Mihm FG, Stanski DR, Rosenthal MH: Zero order pharmacokinetics of high dose thiopental. Anes 51:S204, Sept 1979.
Feeley TW, Mihm FG, Guthaner D, Rosenthal MH: Extravascular thermal volume as an estimate of lung water. Anes 51:S176, Sept 1979.
Mihm FG, Feeley TW, Saul M: Lung water determination in criticaly ill patients. Anes 53:S176, Sept 1980.
Saul M, Feeley TW, Mihm FG: PEEP and lung water measurements after oleic acid. Anes 53:S176, Sept 1980.
Pearl RG, Sladen RN, and Rosenthal MH: Hematological effects of cardiac surgery. Anes 55:A73, 1981.
Rosenthal MH, Pearl RG, Schroeder JS, and Ashton JPA: Nitroglycerin versus nitroprusside in pulmonary hypertension. Anes 55:A79, 1981.
Connelly AS, Feeley TW, Rosenthal MH, Mihm FG, Watkins DW, Ashton JPA: Mechanisms of endotoxin induced pulmonary edema in the dog. Anes 57:A135, Sept 1982.
Calcagni DE, Mihm FG, Feeley TW, Rosenthal MH, and Halperin BD: The thermal-dye method of lung water measurement is reliable at a low cardiac output. Anes 59:A1338, Sept 1983.
Halperin BD, Feeley TW, Mihm FG, Chiles C, Guthaner D, Blank N: Evaluation of the portable chest roentgenograph for quantitating extravascular lung water in critically ill adults. Anes 59:A137, Sept 1983.
Mihm FG and Halperin BD: Non-invasive monitoring of respiratory failure with pulse oximetry and capnography. Anes 59:A136, Sept 1983.
Halperin BD, Pearl RG, Rosenthal MH, Ashton JPA, Mihm FG, Feeley TW: Lung water following resuscitation with colloid and crystalloid solutions. Anes Analg 63:226, Feb 1984.
Shapiro JM, Mihm FG, Stevens JH, Trudell JR, Hertzberg LB, Feeley TW: Cardiopulmonary injury produced by leukotriene D 4 in anesthetized dogs. Anes 61:A115, 1984.
Shapiro JM, White PF, Westphal LM, Sladen RN, Rosenthal MH: Midazolam infusion for sedation in the intensive care unit -effect on adrenal function. Anes 63:A149, 1985.
Stevens JH, O'Hanley P, Shapiro, JM, Mihm FG, Satoh PS, Collins JA, Raffin TA: The effects of anti-C5a antibodies on the adult respiratory syndrome in septic primates. Clin Research 33:473A, 1985.
Brockmann DC, Stevens JH, O'Hanley F, Walker C, Shapiro JM, Mihm FG, Collins JA, Raffin TA: Prostaglandin E 1 does not prevent the adult respiratory distress syndrome in septic shock. Chest 88:195S, 1985.
Cheng EY, Renschler MF, Mihm FG, Sladen RN, Rosenthal MH: Noninvasive respiratory monitoring of patients during weaning from mechanical respiratory support. Anesth Anal 65:S29, 1986.
McLean RF, Pearl RG, Prielipp RC, Rosenthal MH: Comparative analysis of vasodilator effects of PGE 1, hydralazine, sodium nitroprusside and sodium nitroglycerin in a porcine model of pulmonary hypertension. Anes 65:A38, 1986.
Duncan SR, Negrin RS, Mihm FG, Taylor JR, Guiolleminault C, Rattin TA: Treatment of refractory pulmonary atelectasis with nasal continuous positive airway pressure. ARRD 135:A354, 1987.
Ali KH, Feeley TW, Bieber M, McGrath B, Teng NNH: Cardiovascular Effect of intravenous lipid A in rabbits. Cir Shock 23:285-293, l987.
Pearl RG, Rosenthal MH, McLean RF: Effects of total spinal anesthesia on a pulmo-pulmonary reflex. Anes 65:A278, 1986.
Prielipp RC, Pearl RG, and Rosenthal MH: Vasodilator therapy in a vasoconstrictor model of pulmonary hypertension in sheep. Anes 67:A104, 1987.
Prielipp R, Pearl RG, McLean RF, and Rosenthal MH: Effects of prostaglandin E 1, isoproterenol, prostaglandin, and nifedipine in a porcine model of pulmonary hypertension. Anes 67:A154, 1987.
Pearl RG, and Prielipp RC: Rose of leukotrienes in hypoxic pulmonary vasoconstriction in sheep. Anes 67:A549, 1987.
Harada H, Ishizaka A, Mallick A, Hatherill JR, Yonemaru M, Lilly CM, Raffin TA: The effects of methylxanthines on multi-organ damage following E. coli sepsis: Comparison between aminophylline and pentoxifylline. Am Rev Resp Dis 137:116, 1988.
Lilly CM, Sandhu JS, Ishizaka A, Harada H, Raffin TA: Pentoxifylline prevents hypotension in pulmonary injury caused by tumor necrosis factor. Am Rev Resp Dis 137:138, 1988.
Yonemaru M, Zheng H, Stephens KE, Ishizaka A, Sandhu JS, Hatherill JR, Hogue RS, Raffin TA: Biphasic effect of tumor necrosis factor on polymorphonuclear leukocyte chemotaxis. Am Rev Respir Dis 1988;137:42S.
Harada H, Ishizaka A, Mallick A, Hatherill JR, Yonemaru M, Lilly CM, Raffin TA: The effects of methylxanthines on multi-organ damage following E. coli sepsis: Comparison between aminophylline and pentoxifylline. Am Rev Respir Dis 1988;137:116S.
Pearl RG, Siegel LC, and Baer ER: Vasodilators and the longitudinal distribution of pulmonary vascular resistance. Anesthesiology 69:A154, 1988.
Baer ER, Pearl RG, Siegel LC, and Rice SA: Longitudinal distribution of pulmonary vascular resistance during endotoxin-induced pulmonary hypertension in sheep. anesthesiology 69:A860, 1988.
Baer ER, Pearl RG, and Siegel LC: Effects of phorbol myristate acetate on the longitudinal distribution of pulmonary vascular resistance in sheep. Anesthesiology 69:A205, 1988.
Lilly CM, Sandhu JS, Ishizaka A, Harada H, Raffin TA: Pentoxifylline prevents hypotension and pulmonary injury caused by tumor necrosis factor. Am Rev Respir Dis 137:138S, 1988.
Yonemaru M, Zheng H, Stephens KE, Ishizaka A, Sandhu JS, Hatherill JR, Hogue RS, Raffin TA: Biphasic effect of tumor necrosis factor on polymorphonuclear leukocyte chemotaxis. Am Rev Respir Dis 137:42S, 1988.
Kraft SA, Larson CP, Shuer LM, SteinbergGK, Benson GV, Pearl RG. Hyperglycemia decreases neuronal ischemic damage in a rabbit model of focal cerebral ischemia. Anesthesiology 71: A634, 1989.
Finn JC, Pearl RG, Siegel LC. Validation of pulmonary artery occlusion profile decay analysis in intact sheep. Anesthesiology 71:A173, 1989.
Kraft SA, Fujishima S, McGuire GP, Raffin TA, Pearl RG: Mechanism of pulmonary hypertension in isolated rabbit lungs perfused with autologous blood. Am Rev Respir Dis 141:A484, 1990.
McGuire GP, Kraft SA, Fujishima S, Raffin TA: The effect of hematocrit and albumin on pulmonary vascular resistance and edema in isolated perfused rabbit lungs. Am Rev Respir Dis 141:A298, 1990.
Fujishima S, McGuire GP, Kraft SA, Raffin TA, Pearl RG: Isoproterenol attenuates the oxidant-induced increase in vascular permeability in isolated rabbit lungs. Am Rev Respir Dis 141;A917, 1990.
Cook DJ, Chan J, Dunn C, Bergen CJ, Duncan SR: Late occurring pneumonia in heart transplant recipients. Am Rev Respir Dis 141:A604, 1990.
Wakerlin G, Flavin T, Siegel LC, Benson GV, Pearl RG. Pulmonary capillary pressure measurement from pulmonary artery occlusion pressure profile analysis. Anesthesiology 73:A1163, 1990.
Wakerlin G, Pearl RG. Mechanism, of thromboxane-induced pulmonary edema. Anesthesiology 73:A1165, 1990.
Cook DJ, Duncan SR: Pulmonary CMV infection in heart transplant recipients. (Submitted to the ACCP 56th Annual Scientific Assembly).
Barr J, Mihm FG, Gaeta R: A comparison of central and peripheral intra-arterial blood pressure measurements in ICU patients receiving vasoconstrictive agents. Anesthesiology. 75(3A):A283, 1991.
Schwartz GG, Steinman S, Garcia J, Greyson C, Massie B, Weiner MW: In Vivo 31P Spectroscopy of the Porcine Right Ventricle: Response to Acute Pressure Overload. 10th Annual Scientific Meeting of the Society of Magnetic Resonance in Medicine, 1991.
Schwartz GG, Steinman S, Garcia J, Greyson C, Weiner MW, Massie B: Energetics of Acute Right Ventricular Pressure Overload. 64th Scientific Sessions, American Heart Association, 1991.
Kraft SA, Raffin TA, Pearl RG. Effects of prostaglandin E 1 on segmental pulmonary vascular pressures. American Review of Respiratory Disease 143:A78, 1991.
Barr J, Egan T, Feeley T, Shafer S: Depth of sedation vs. Propofol concentration in mechanically ventilated ICU patients. Anesthesiology 77:A313, 1992
Barr J, Egan T, Feeley T, Shafer S: The pharmacokinetics of propofol administered by computer - controlled infusion in mechanically ventilated ICU patients. Anesthesiology 77:A345, 1992.
Kramer BA, Pearl RG. Terbutaline and 8-bromo-cyclic AMP decrease oxidant-induced lung injury. American Review of Respiratory Disease 145:A849, 1992.
Deem S, Siegel LC, Pearl RG. Estimates of pulmonary capillary pressure are affected by the method used to determine the moment of pulmonary occlusion. Anesthesiology 77:A1244, 1992.
Pearl RG, Lindeborg DM. Prostacyclin (PGL 2) is a venodilator in perfused rabbit lungs. American Review of Respiratory Disease 147:A140, 1993.
Lindeborg DM, Xu H, Pearl RG. Inhaled nitric oxide (NO) and the longitudinal distribution of pulmonary vascular resistance. American Review of Respiratory Disease 147:A225, 1993.
Kavanagh BP, Mouchawar AM, Pearl RG. Effects of inhaled and endogenous nitric oxide on oxidant-induced acute lung injury. Anesthesiology 79:A1228, 1993.
Lindeborg DM, Pearl RG. Inhaled nitric oxide does not alter the longitudinal distribution of pulmonary vascular resistance. Anesthesiology 79:A1239, 1993.
Kavanagh BP, Thompson JS, Pearl RG. Inhibition of endogenous nitric oxide synthase potentiates the effects of notrivasodilators, but not of AMP medicated vasodilators, in experimental pulmonary hypertension. Anesthesiology 81:A1492, 1994.
Thompson JS, Kavanagh BP, Pearl RG. Leukocyte removal by filtration prevents pulmonary hypertension in the blood-perfused rabbit lung. Anesthesiology 91:A1460, 1994.
Wall MH, Pearl RG. Inhibition of endogenous nitric oxide synthesis does not alter the effects of adenosine in experimental pulmonary hypertension. Anesthesiology 81:A646, 1994.
Thompson JS, Kavanagh BP, Pearl RG. Nitroglycerin does not alter pulmonary capillary permeability. American Journal of Respiratory and Critical Care Medicine 151:A619, 1995.
Wall MH, Patterson KW, Kavanagh BP, Pearl RG. Inhibition of endogenous nitric oxide synthase produces supersensitivity to the pulmonary vasodilator effects of nitroprusside. American Journal of Respiratory and Critical care Medicine 151:A729, 1995
Goldsmith J, Kavanagh BP, Pearl RG. Plasma potentiates the priming effects of endotoxin in rabbit lungs. American Journal of Respiratory and Critical Care Medicine 151:A829, 1995.
Rodriguez RM, Wang NE, Pearl RG. Prediction of futile ICU care from the emergency department. Critical Care Medicine 24:A54, 1996.
Mirza I, Nagamine J, Pearl RG. Additive effects of inhaled prostacyclin and inhaled nitric oxide in reducing experimental pulmonary hypertension. Anesthesiology 87:A1122, 1997.
Aranda M, Kilroy K, Pearl RG. Combined therapy with inhaled nitric oxide and intravenous vasodilators during experimental pulmonary hypertension. Anesthesiology 87:A1123, 1997.
Nagamine J, Hill L, Mirza I, Pearl RG. Combined therapy with inhaled nitric oxide and zaprinast reverses hypoxic pulmonary hypertension. Anesthesiology 87:A1110, 1997.
Rodriguez RM, Corwin HL, Pearl RG, Corwin MJ, Enny C, Gettinger A. Iron, B 12 and folate deficiency in ICU patients. Critical Care Medicine 25:A80, 1997.
Corwin HL, Rodrigeuz RM, Pearl RG, Enny C, Corwin MJ, Gettinger A. Erythropoietin response in critically ill patients. Critical Care Medicine 25:A82, 1997.
Nagamine J, Hill L, Mirza I, Pearl RG. Combined therapy wit inhaled nitric oxide and zaprinast reverses hypoxic pulmonary hypertension. Anesthesiology 87:A1110, 1997.
Huang JH, Adi V, Oeffner P, Ratnam K, Trako E, Aoki Y, Ruoss SJ, Kao PN. Analysis of the NRAMP1 gene in non-HIV patients with mycobacterium avium-intracellulare (MAI) bronchiectasis. Am J Resp Crit Care Med. 155(4):A335, 1997.
Corwin HL, Gettinger A, Rodriguez RM, Pearl RG, Gubler D, Enny C, Colton T, Corwin MJ. Efficacy of recombinant human erythropoietin in the critically ill patient: a randomized double-blind placebo controlled trial. Critical Care Medicine 26:A23, 1998.
Rodriguez RM, Pearl RG, Beringer KA, Sher MH, Caro RC. Nitrovasodilators alter the arterial blood-pressure-pressure wave velocity relationship. Critical Care Medicine 226:A61, 1998.
Hill L, Pearl RG. Hypoxia prolongs the effect of inhaled nitric oxide. Anesthesiology 89:A1371, 1998.
Rubin GD, Gosselin MV, Leung AN, Huang J, Rizk NW. Prospective detection of unsuspected pulmonary embolism on routine spiral CT scan. Radiological Society of North America, 84 th Scientific Assembly and annual Meeting, 1998.
Hill LL, Peral RG, Jing M, Muldoon SM. Halothane attenuates the effects of inhaled nitric oxide. Critical are Medicine 27:A159, 1999.
Graham R, Thompson L, Barr J, Bertaccini E, Carieri-Kohlman V, Geller E.
Sarinas PSA, Chitkara RK, Kuschner WG, Traylor RJ, Segall GM. F18-FDG PET characterization of pericardial malignancy from lung cancer (submitted for publication), 2000.
Chan PKO, Mehta S, Lapinsky S, Tomlinson G, MascDonald R, Hynes-Gapy P, Esteban A, Anzueto A, Fowler R, Stewart T. Evaluation of a protocolized approach to extubation. American Thoracic Society, Toronto, Canada 2000

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