Principal Investigator and Director

Howard Y. Chang, MD, PhD
Virginia and D. K. Ludwig Professor of Cancer Research, Professor of Genetics and, by courtesy, of Pathology

Dr. Chang is a physician scientist who has pioneered studies of the noncoding genome. He is interested in how the activities of hundreds or even thousands of genes (gene parties) are coordinated to achieve biological meaning. His team will focus on studies of lncRNA-genome interaction and clinical regulome analyses. Lab Website. 

Co-Principal Investigators

Christina Curtis
Associate Professor of Medicine ( Oncology ) and Genetics

Dr. Curtis pursues systems biology and computational approaches to establish a quantitative and mechanistic understanding of cancer progression. Her research has helped to redefine the molecular map of breast cancer and has led to new paradigms in understanding how human tumors progress. Her team will focus on characterizing regulatory programs in cancer and inferring tumor evolutionary dynamics. Lab Website. 

William Greenleaf
Professor of Genetics

Dr. Greenleaf is building new tools to leverage the power of high-throughput sequencing and cutting-edge microscopies, and bringing these new technologies to bear against basic biological questions of genomic and epigenomic variation. His group will focus on methods development components of the project, including transposase-based accessible chromatin methods, and higher-order structure determination.  Lab Website.

Michael Snyder, Ph.D.
Stanford W. Ascherman Professor of Genetics

Dr. Snyder is a worldwide leader in applying omics approaches of genome sequencing, transcriptomics proteomics, metabolomics, DNA methylation and microbiome assays to the analysis of human disease. Dr. Snyder will coordinate the activities of the DNA methylation project and work closely with Drs. Greenleaf and Chang on the mapping of regulation information in personal genomes. Lab Website. 

Alexander Eckehart Urban
Associate Professor of Psychiatry and Behavioral Sciences (Major Laboratories and Clinical Translational Neurosciences Incubator) and of Genetics

Dr. Urban is investigating the molecular effects of large genome variants during neuronal development using iPSC model systems and the study of the nature and effects of somatic genome variation in the brain using tissue culture models and primary tissue samples. Dr. Urban will focus on coordinating whole-genome sequence analyses as well as the development of the allele-specific methylome sequencing technology.  Lab Website. 

Wing Hung Wong
Stephen R. Pierce Family Goldman Sachs Professor of Science and Human Health and Professor of Biomedical Data Science

Dr. Wong’s current interest centers on the application of statistics to problems arising from biology, in particular questions concerning gene regulation and signal transduction. The Wong Lab will focus on computational analysis of personal regulome data. Lab Website. 



Hanmin Guo | Urban and Wong Labs

Brian Johnson | Snyder Lab

Andrew Koh | Crabtree Lab

Sandy Klemm | Greenleaf Lab

Yang Li | Pritchard Lab

Shin Lin | Snyder Lab

Georgi Marinov | Greenleaf Lab

Qiao Liu | Wong Lab

Samuel Lancaster | Snyder Lab


Sai Zhang | Snyder Lab

Pingping Qu | Urban Lab

Bo Zhou | Urban Lab

Morteza Roodgar | Snyder Lab

Shannon White | Snyder Lab

Yizhou Zhu | Snyder Lab

Wanwen Zeng | Wong Lab

Reenal Pattni | Urban Lab

Graduate Students


Michaela Hinks | 
Greenleaf Lab

Benjamin Doughty | Greenleaf Lab

Julia Schaepe | Greenleaf Lab

Betty Liu | Greenleaf Lab






Hang Xu | Curtis Lab

Jose Seoane | Curtis Lab



Gerald Crabtree
Pathology and Developmental Biology, Stanford University

Paul Khavari
Dermatology, Stanford University

Youn Kim
Dermatology, Stanford University

Anshul Kundaje
Genetics and Computer Science, Stanford University

Calvin Kuo
Medicine (Hematology), Stanford University

Liqun Luo
Biology, Stanford University

Emmanuel Mignot
Psychiatry, Stanford University

Dana Pe'er
Biological Sciences, Columbia University

Jonathan Pritchard
Genetics and Biology, Stanford University

Lihua Jiang
Genetics and Biology, Stanford University