Overview

We are looking at how improving sleep improves neuropsychiatric symptoms that are commonly present in individuals between the ages of 25-60 with depression and/or anxiety. This study utilizes high density EEG sleep recordings and neuroimaging.

This study is actively recruiting! 

Click the button below to enter your contact information to join the Study List. A member of our team will contact you shortly with more information about participating in the study!

What is an EEG?

• An electroencephalogram (EEG) is a test that detects and records electrical activity in your brain using small, metal discs (electrodes) attached to your scalp. Your brain cells communicate via electrical impulses and are active all the time, even when you're asleep. EEG recordings  help us understand more about your sleep issues. 

Can I take the EEG off myself?

• No, a trained member of the study staff must remove all the electrodes. The equipment is very fragile and expensive and therefore needs to be done by a member of the study staff. 

What is an MRI?

• MRI (magnetic resonance imaging) uses a strong magnetic field and radio waves to create detailed images of the organs and tissues within the body. For this study, we are only capturing photos of the brain. There is no radiation during a MRI and the procedure is non-invasive. If you feel uncomfortable during the scan, investigators will be able to hear you the entire time and the scan can be stopped or paused.

Can I close my eyes during the MRI?

• No, there are game-like tasks that you will need to complete while you are in the scanner. You will be looking at a TV and asked to respond to questions that appear on the screen.

Where are the study visits?

• Treatment sessions will be held over zoom (these may be conducted in person as COVID-19 Pandemic restrictions ease). Screening sessions will take place at 1520 Page Mill Road. Baseline and End of Treatment follow-ups will be in Building 420 on Stanford University’s Campus.

How long is each session?

• The initial zoom screening and in-person evening screening session are about 1.5 hours each. The morning aspect of the screening session will take around 20 minutes. Both the baseline and ETX evening sessions will last around 2 hours. The successive baseline and ETX morning sessions will then last around 4 hours. Each treatment session will last around 60 minutes.

Overview

We are looking at how improving sleep improves neuropsychiatric symptoms that are commonly present in individuals with Mild Cognitive Impairment and early Alzheimer's Disease. This study utilizes high-density EEG sleep recordings and neuroimaging.

This study is actively recruiting! 

Click the button below to enter your contact information to join the Study List. A member of our team will contact you shortly with more information about participating in the study!

What is an EEG?

• An electroencephalogram (EEG) is a test that detects and records electrical activity in your brain using small, metal discs (electrodes) attached to your scalp. Your brain cells communicate via electrical impulses and are active all the time, even when you're asleep. EEG recordings  help us understand more about your sleep issues. 

Can I take the EEG off myself?

• No, a trained member of the study staff must remove all the electrodes. The equipment is very fragile and expensive and therefore needs to be done by a member of the study staff. 

What is an MRI?

• MRI (magnetic resonance imaging) uses a strong magnetic field and radio waves to create detailed images of the organs and tissues within the body. For this study, we are only capturing photos of the brain. There is no radiation during a MRI and the procedure is non-invasive. If you feel uncomfortable during the scan, investigators will be able to hear you the entire time and the scan can be stopped or paused.

Can I close my eyes during the MRI?

• No, there are game-like tasks that you will need to complete while you are in the scanner. You will be looking at a TV and asked to respond to questions that appear on the screen.

Where are the study visits?

• Treatment sessions will be held over zoom (these may be conducted in person as COVID-19 Pandemic restrictions ease). Screening sessions will take place at 1520 Page Mill Road. Baseline and End of Treatment follow-ups will be in Building 420 on Stanford University’s Campus.

How long is each session?

• The initial zoom screening and in-person evening screening session are about 1.5 hours each. The morning aspect of the screening session will take around 20 minutes. Both the baseline and ETX evening sessions will last around 2 hours. The successive baseline and ETX morning sessions will then last around 4 hours. Each treatment session will last around 60 minutes.

What is a study partner? Why do I need a study partner?

• A study partner can be anyone over 18 years old that you speak to regularly. Study partners will give the researchers additional information about your functioning during the study period. The study partner will be the same throughout the study.

What does a study partner do?

• Study partners have a few responsibilities. At the evening screening session, they will go over the consent form with a member of the study staff (around 20-25 minutes). In the morning screening session, they must complete a questionnaire and assessment with a member of the staff. Finally, at baseline, the end of treatment follow-up, and the six-month follow-up, the study partner must complete 2 questionnaires about the participant. The study partner pieces can be completed either in person or remotely.

This study is sponsored by the Department of Veteran Affairs to compare and contrast two non-drug treatments for insomnia in veterans of the Gulf War who are experiencing sleep disturbance.

This research study is examining the impacts of an early sleep intervention on sleep difficulties and neuropsychiatric symptoms that have developed or worsened as a result of the COVID-19 Pandemic and related shelter-in-place restrictions.  We hope to learn whether improving sleep early on can prevent more serious, chronic sleep conditions from developing later and improve neuropsychiatric symptoms.