Stanford Genome Technology Center

About the Center

Developing Cost-Effective Technology at the Intersection of Biochemistry, Electrical Engineering, & Genetics

Our center develops new technologies to address important biological questions that otherwise would not be feasible. Our successes can involve improvements to existing technologies or completely new inventions, both of which aim to increase speed and accuracy while decreasing cost. In turn, once a new technology has been developed or advanced, it can often drive the perception of what is possible in the realm of experimental biology.

Historically, this synergism between biology and technology has thrived at SGTC as applied to yeast functional genomics and large-scale sequencing efforts. In the next phase of our evolution we will use yeast as the test-bed of advanced technologies to enable novel solutions to the greatest challenges facing human health, most noteworthy being Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME/CFS).

Under his direction, SGTC has become a trailblazer in developing and deploying biomedical technologies, with ~70 patents and ~30 spin-out companies

Current Research Projects

Characterization of proteolytic antibodies in ME-CFS

Our project explores the possibility that antibodies (Ab)s with proteolytic activity may exist in some patients with ME-CFS. These unique autoantibodies, also called Abzymes (Abz)s, combine the natural structure and function of an antibody with properties of an enzyme. Abzs may target DNA, RNA, protein, peptides or other macromolecular structures, where they bind to the substrate with high specificity and break it down in situ.

High multiplex PCR technology in ME-CFS and Long-COVID

Using high multiplex PCR developed at Stanford Genome Technology Center, we study viral reactivation in ME/CFS, Long-COVID, trauma and sepsis. The viruses we focused on are EBV, HHV6 and CMV. Currently, we have ~450 PCR amplicons to sequence each and every gene in HHV6 and EBV genome.

Determining the role of itaconate shunt in mitochondrial dysfunction in the pathogenesis of ME-CFS disease

Myalgic Encephalomyelitis (ME), commonly referred to as Chronic Fatigue Syndrome (CFS), is a debilitating condition characterized by profound fatigue, post-exertional malaise, and a range of neurocognitive, and other systemic symptoms. Emerging evidence suggests that mitochondrial dysfunction plays a pivotal role in the pathophysiology of ME/CFS.

Highlights

Ron Davis named one of today's greatest inventors

"Who Will Tomorrow's Historians Consider Today's Greatest Inventors?" Atlantic Magazine asked leading figures in science, technology, medicine and design for nominations. Ron was called a "frequent provider of disruptive core technologies". Read full story »

Stanford, UCSC Researchers Develop Digital Array Technique for NGS Counting Applications

Researchers from Stanford and the University of California, Santa Cruz have developed a technique that combines aspects of microarray technology with next-generation sequencing. Described in a study published this month in PLoS One, the sequencing bead array, or SBA, technique is "a suspension array for next-gen sequencing platforms" that replaces the optical readout with a label-free digital readout, or barcode, lead author Michael Akhras, a postdoctoral researcher at Stanford, told In Sequence. Rather than using the next-gen sequencing system to evaluate each base pair, next-gen sequencing is used to check for the presence of a target. Read full story »

Ronald W. Davis awarded Warren Alpert Foundation Prize

Ronald W. Davis and David S. Hogness, both of Stanford University School of Medicine, and David Botstein of Princeton University, are the recipients of the 2013 Warren Alpert Foundation Prize for their seminal contributions to concepts and methods of creating a genetic map in the human, and of positional cloning, leading to the identification of thousands of human disease genes and ushering in the era of human genetics. The 2013 Warren Alpert Foundation Prize Scientific symposium will be held in their honor on Thursday afternoon, October 3rd in the Joseph B. Martin Conference Center, Harvard Medical School. Read full story »