Levels of retinoic acid, a vitamin A metabolite, are low in mice and humans with colorectal cancer, according to new research. People with high levels of an enzyme that degrades retinoic acid have a poor prognosis.
Inhibiting the firing of nerve cells in a brain area long known to guide goal-directed behavior makes mice build nests and fall asleep, a new study shows. Stimulating the circuit roused the mice and kept them awake.
Osteosarcoma patients with tumors that haven’t responded well to the standard chemotherapy regimen have unimproved outcomes and more side effects when given two additional drugs, a large international trial has found.
More Egyptian women are seeking the opinions of physicians on whether their daughters should undergo female genital cutting, which is illegal in the country, but they say doctors don’t advise against the procedure.
Making cell- or virus-based therapies for use in humans requires a rigid set of quality-control standards outlined by the Food and Drug Administration. A new Stanford facility will allow promising new therapies to be tested in the clinic.
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