Research and Discovery: The Comparative Approach

The concept of “One medicine, one health” is based upon a fundamental idea: advances in both human and veterinary medicine are dependent on overlapping technologies and research discoveries. This is the essence of Comparative Medicine-- the study of the close connections between human and animal health and disease.

The faculty in the Department of Comparative Medicine are basic researchers or veterinary clinician scientists, all working toward one health. Basic scientist faculty use animal models of epilepsy, neuronal reorganization and recovery after injury, and cortical neuronal circuitry to study physiological and patho-physiological processes. The veterinary clinical faculty in the Department of Comparative Medicine research interests focus on topics pertaining to laboratory animal and wildlife health, and on animal models of human disease. The species studied are diverse, ranging from rodents to the African Clawed frog.

Faculty Book Publications

Green S.L.:  The Laboratory Xenopus sp provides researchers and lab managers with a practical, step-by-step manual that emphasizes the humane care and use of captive clawed frogs in basic as well as biomedical, and toxicological research.  CRC Press 2009

Winnicker C., Gaskill B., Garner J., Pritchett-Corning, K.  A Guide to the Behavior & Enrichment of Laboratory Rodents. Boston: Charles River Laboratories 2012

Pacharinsak C, Smith J.C.:  Handbook of Laboratory Anesthesia and Pain Management: Rodents covers anesthetic machine and related equipment, anesthetic management and monitoring, anesthesia and analgesia pharmacology, euthanasia, and record keeping.  CRC Press 2017

Faculty Journal Publications

Lucot KL, Bukhari SA, Webber ED, Bonham TA, Darian-Smith C, Montine TJ, Green SL.  Semi-quantitative assessment of Alzheimer's-like pathology in two aged polar bears (Ursus mairtimus).  Comp Med 2022, 72(4):267-272.

© AALAS

Zlatow AL, Wilson S, Bouley DM, Tetens-Woodring J, Buchholz DR, Green SL.  Axial skeletal malformations in genetically modified Xenopus laevis  and Xenopus tropicalis.  Comp Med 2020, 70(6):532-541.

McCann MM, Fisher KM, Ahloy‐Dallaire J, Darian-Smith C. Somato-sensory corti-cospinal tract axons sprout within the cervical cord following a dorsal root/dorsal column spinal injury in the rat.  J Comp Neurol  2020, 528(8):1293-1306.

Thank you to Dr. Darian-Smith and Wiley Periodicals for permission to post.  © 2019 Wiley Periodicals, Inc.

Kang SC, Jampachaisri K, Seymour TL, Felt SA, Pacharinsak C
Use of liposomal bupivacaine for postoperative analgesia in an incisional pain model in rats (Rattus norvegicus).
JAALAS Jan 2017, 56(1):63-68.

Ezran C, Karanewsky CJ, Pendleton JL, Sholtz A, Krasnow MR, Willick J, Razafindrakoto A, Zohdy S, Albertelli MA, Krasnow MA. The mouse lemur, a genetic model organism for primate biology, behavior, and health. Genetics 2017, 206(2):651-664.

Garner JP, Gaskill BN, Weber EM, Ahloy-Dallaire J, & Pritchett-Corning KR. Introducing Therioepi- stemology: the study of how knowledge is gained from animal research. Lab Anim (NY), 2017, 46(4), 103-113. doi:10.1038/laban.1224

Hofmann G, Balgooyen L, Mattis J, Deisseroth K, Buckmaster PS.
Hilar somatostatin interneuron loss reduces dentate gyrus inhibition in a mouse model of temporal lobe epilepsy.
Epilepsia 2016, Jun 57(6): 977–983.

Kim J., Matney C. J., Blankenship, A., Hestrin S., Brown S. P.  Layer 6 corticothalamic neurons activate a cortical output layer, layer 5a. J Neurosci 2014, 34 (29), 9656-9664.

Wilson S, Felt S, Torreilles S, Howard A, Behan C, Moorhead R, Green S:  Serum clinical biochemical and hematologic reference ranges of laboratory-reared and wild-caught Xenopus laevis.  JAALAS 2011, 50(5), 635-640.

Updated March 1, 2023