NIH/NIBIB/R01 EB009055 (PI Hargreaves, Co-I Ennis)                          03.01.2020 to 11.30.2023

High Resolution Whole-Breast MRI at 3.0T

This research will develop much higher resolution breast MRI, allowing better classification of small lesions to prevent unnecessary biopsy and detect cancer earlier.

NIH/NHLBI/R01 HL152256 (PI Ennis)                                                  06.24.2020 to 05.31.2024

Using Atrial Mechanics to Identify Fibrosis in Patients with Atrial Fibrillation

We propose to use magnetic resonance imaging (MRI) of atrial mechanics to identify localized fibrosis and hypothesize that attenuated mechanics provide a robust measure of atrial fibrosis.

NIH/NHLBI/R01 HL152155 (PI Woo, Co-I Ennis)                                   05.05.2020 to 04.30.2024

Biomechanical Optimization of Cardiac Valve Repair Operations

We will validate our findings using large animal cardiac surgery models, and then hopefully translate these discoveries directly to the operating room in the human clinical arena.

NIH/NIBIB/U01 EB029427 (PI Vasanawala, Co-I Ennis)                         08.01.2020 to 07.31.2024

Enabling the Next Generation of High Performance Pediatric Whole-Body MR Imaging

The goal of this project is to create and validate the next generation systems for pediatric MRI.

NIH/NCI/R01 CA249893 (PI Hargreaves, Co-I Ennis)                             02.01.2021 to 01.31.2026

Abbreviated Non-Contrast-Enhanced MRI for Breast Cancer Screening

The goal of this project is to provide fast, accurate, accessible non-contrast—enhanced MRI screening methods to safely detect breast cancer in the high-risk population. 

Audentes Therapeutics, Inc. AT845-01 (PI JW Day, Co-I Ennis)              05.29.2020 to 03.31.2027

FORTIS: A Phase 1/2, Open-Label, Ascending-Dose Clinical Study to Evaluate the Safety and Preliminary Efficacy of AT845, an AAV8-Delivered Gene Transfer Therapy in Patients with Late Onset Pompe Disease

The goal of this project is to determine efficacy and safety profile of gene replacement in Pompe disease.

GE Healthcare A-127, A-133, A-134, A-137 (PI Vasanawala, Co-I Ennis)   07.01.2022 to 06.30.2024

GE Healthcare - Stanford Artificial Intelligence in Medical Imaging Research

The major goal of the project is to develop methods of upstream medical imaging artificial intelligence to optimize the selection, scheduling, protocoling, and execution of exams.

NIH/NIAMS/R01 AR078912 (MPI Hargreaves, Co-I Ennis)                      02.01.2022 to 12.31.2026

Improved Diagnostic MRI Around Metallic Implants

This project will develop improved MRI technology, using a new high- performance low-field instrument, to evaluate soft tissues within a few millimeters of most implants, which we cannot see with any current technology.

NIH/NIBIB/R01 EB029306 (PI Boada, Co-I Ennis)                                 09.15.2022 to 01.31.2024

MR/PET Motion Correction from Coil Fingerprints

This proposal is devoted to the development, clinical implementation, and evaluation of a novel, real-time, motion correction methodology for concurrent MR/PET acquisitions. 

GE Healthcare A-128 (PI Daniel, Co-I Ennis)                                        09.01.2022 to 08.31.2024

A-128 I Stanford Body MRI Tiger Team 2022-24

The overall purpose of this research is to advance the state of the art of technology for body MRI scanning.

GE Healthcare A-129 (PI Ennis)                                                          09.01.2022 to 08.31.2024

A-129 I Stanford Tiger Team 2022-2024: Advanced Cardiac Functional and Flow MRI for Pediatrics and Adults

The purpose of this proposal is to develop and refine several methods for fast and artifact free cardiac functional and flow imaging. This project leverages our prior experience applying deep learning-based reconstruction methods to 2D PC-MRI measurements and time-optimal pulse sequence design. By incorporating these novel methods, we aim to enable single-beat 2D PC-MRI and artifact free bSSFP cine imaging, we intend to generate a comprehensive flow and functional cardiac exam that can be widely used in the clinic

GE Healthcare A-130 (PI Salerno, Co-I Ennis)                                       09.01.2022 to 08.31.2024

A-130 I Stanford Cardiac MR Tiger Team 2022-2024: Advanced Techniques for Quantitative Stress Perfusion and Parametric Mapping

The major goals are to optimize GE perfusion sequences and AIR DL for Quantitative stress perfusion. To develop and evaluate MR multi-tasking for Cine and T1 mapping.

NIH/NIBIB/T32 EB032755 (MPI Butts Pauly/Ennis)                               05.01.2023 to 04.30.2028

Stanford’s Translational Biomedical Imaging Instrumentation (TBI2) Training Program

This multidisciplinary predoctoral training program will train the next generation of researchers and inventors of biomedical imaging technology. Trainees will gain expertise in multiple medical imaging modalities, rigorous and reproducible experimental design, and translational applications. Trainees that complete our training program will have a unique skill set that fulfills a distinct national need for researchers and leaders with expertise in advanced biomedical imaging instrumentation. 

University of Florida/REGENXBIO Inc./RGX-202-1101 (PI Ennis)             07.01.2023 to 12.31.2024

A Phase 1-2 Open-label, Dose Escalation and Dose Expansion Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of Intravenous RGX-202 Gene Therapy in Males with Duchenne Muscular Dystrophy (DMD)

The major goal is to evaluate the safety and efficacy of a new therapy for treating boys with DMD. 

NIH/NIMH/R01 MH131684 (PI Butts Pauly, Co-I Ennis)                          08.14.2023 to 05.31.2027

Step 1 in Designing Appropriate Shams and Controls in Human TUS

The purpose of this proposed research is to increase the rigor and safety, and therefore success, of TUS in the treatment of SUDs, and TUS more generally, thereby enabling truly innovative science. 

Previous Grants as Principal Investigator

NIH/NHLBI K99-R00 HL087614 [2008-2012]  

Myocardial structure, function, and remodeling in mitral regurgitation

Pilot Project under NIH/NIAMS P30AR057230 (PI Spencer) [2012-2013]  
Quantitative Cardiovascular MRI for Pediatric Patients with Duchenne Muscular Dystrophy

AHA 13BGIA14530010 Beginning Grant In Aid [2013-2015]  
Complete Free-Breathing Cardiovascular MRI Exam for Pediatric Patients with Cardiomyopathy

Siemens Medical Solutions, USA [2013-2017]  
Technical Developments for 3T MRI Clinical Applications

NIH/NHLBI R21 HL127433 [2015-2017]  
Are 3T MRI Exams Safe For Patients with Pacemakers and ICDs?

NIH/NHLBI K25 HL135408 [2017-2020]  
Defining and Measuring Diastolic Myocardial Kinematics and Stiffness

AHA 19IPLOI34760294 [2019-2021]  
The Cardiac Connectome for Understanding the Electromechanics of Heart Failure 

NIH/NHLBI R01 HL131975 [2016-2022]  
Validating Cardiac MRI Biomarkers and Genotype-Phenotype Correlations for DMD

NIH/NHLBI R01 HL131823 [2018-2022]  
A New Framework for Understanding the Mechanisms of Diastolic Dysfunction