NIH/NHLBI/R01 (PI Ennis, HL131975)                                                  04.01.2016 to 03.31.2022

Validating Cardiac MRI Biomarkers and Genotype-Phenotype Correlations for DMD

One objective of this project is to define the precision and reproducibility of several diagnostic cardiac MRI biomarkers obtained during a fast, free-breathing cardiac MRI exam. This will enable the team to bridge the significant multi-year diagnostic gap between early genotyping and the late onset of overt cardiac symptoms. A second objective is to define the cardiac-specific genotype-phenotype correlation via outlier analysis.

NIH/NHLBI/R01 (PI Ennis, HL131823)                                                  09.01.2018 to 06.30.2022

A New Framework for Understanding the Mechanisms of Diastolic Dysfunction

The objective of this project is to use an Equilibrium-Material-Stability (EMS) framework that couples patient- specific clinical MRI and LV pressure data in a computational model of the heart to diagnose changes in diastolic myocardial stiffness.

AHA (PI Ennis, 19IPLOI34760294)                                                       07.01.2019 to 06.30.2021

The Cardiac Connectome for Understanding the Electromechanics of Heart Failure

The goal of this study is to develop whole-heart multi-modal imaging of cardiac microstructural connectivity and to quantitatively characterize the whole-heart cardiac connectome.

NIH/NIBIB/U01 (PI Vasanawala, Co-I Ennis, EB029427)                         08.01.2020 to 07.31.2025

Enabling the Next Generation of High Performance Pediatric Whole-Body MR Imaging

The goal of this project is to create and validate the next generation systems for pediatric MRI.

NIH/NIBIB/R01 (PI Hargreaves, Co-I Ennis, EB009055)                          03.01.2020 to 11.30.2023

High Resolution Whole-Breast MRI at 3.0T

This research will develop much higher resolution breast MRI, allowing better classification of small lesions to prevent unnecessary biopsy and detect cancer earlier.

NIH/NHLBI/R01 (PI Woo, Co-I Ennis, HL152155)                                   05.05.2020 to 04.30.2024

Biomechanical Optimization of Cardiac Valve Repair Operations

We will validate our findings using large animal cardiac surgery models, and then hopefully translate these discoveries directly to the operating room in the human clinical arena

NIH/NHLBI/R01 (PI Ennis, HL152256)                                                  06.24.2020 to 05.31.2024

Using Atrial Mechanics to Identify Fibrosis in Patients with Atrial Fibrillation

We propose to use magnetic resonance imaging (MRI) of atrial mechanics to identify localized fibrosis and hypothesize that attenuated mechanics provide a robust measure of atrial fibrosis.

Audentes Therapeutics, Inc. (PI JW Day, Co-I Ennis, AT845-01)              05.29.2020 to 03.31.2027

FORTIS: A Phase 1/2, Open-Label, Ascending-Dose Clinical Study to Evaluate the Safety and Preliminary Efficacy of AT845, an AAV8-Delivered Gene Transfer Therapy in Patients with Late Onset Pompe Disease

The goal of this project is to evaluate the safety of a novel gene therapy for patients with Pompe disease – a genetic disease that results in the build-up of glycogen in the body’s cells. One aspect of this study will use cardiac MRI exams to evaluate heart health.

NIH/NCI/R01 (PI Hargreaves, Co-I Ennis, CA249893)                             02.01.2020 to 01.31.2026

Abbreviated Non-Contrast-Enhanced MRI for Breast Cancer Screening

We aim to provide accurate, low-cost, comfortable, MRI screening without intravenous contrast, in a 10-minute exam. This will ultimately enable more effective and comfortable breast cancer screening for millions of women for whom x-ray mammography is insufficient.

Previous Research Support as PI

NIH/NHLBI K99-R00 HL087614 [2008-2012] 
Myocardial structure, function, and remodeling in mitral regurgitation

Pilot Project under NIH/NIAMS P30AR057230 (PI Spencer) [2012-2013]  
Quantitative Cardiovascular MRI for Pediatric Patients with Duchenne Muscular Dystrophy

AHA 13BGIA14530010 Beginning Grant In Aid [2013-2015]  
Complete Free-Breathing Cardiovascular MRI Exam for Pediatric Patients with Cardiomyopathy

Siemens Medical Solutions, USA [2013-2017]  
Technical Developments for 3T MRI Clinical Applications

NIH/NHLBI R21 HL127433 [2015-2017]  
Are 3T MRI Exams Safe For Patients with Pacemakers and ICDs?

NIH/NHLBI K25 1K25HL135408 [2017-2020]  
Defining and Measuring Diastolic Myocardial Kinematics and Stiffness