Grants

NIH/NIBIB/T32 EB032755 (MPI Butts Pauly/Ennis)

05.01.2023 to 04.30.2028

Stanford’s Translational Biomedical Imaging Instrumentation (TBI2) Training Program

This multidisciplinary predoctoral training program will train the next generation of researchers and inventors of biomedical imaging technology. Trainees will gain expertise in multiple medical imaging modalities, rigorous and reproducible experimental design, and translational applications. Trainees that complete our training program will have a unique skill set that fulfills a distinct national need for researchers and leaders with expertise in advanced biomedical imaging instrumentation. 

NIH/NIBIB/R01 HL171515 (PI Ennis)

01.01.2024 to 12.31.2027

Fast and Accurate Cardiovascular MRI with Hyper 4D-Flow

This proposal aims to enable fast, accurate, and robust 4D-Flow image acquisitions; fast and accurate 4D-Flow image reconstruction; and to evaluate our 4D-Flow methods in children with repaired tetralogy of Fallot (rTOF).

NIH/NHLBI/R01 HL162260 (Sub-PI Ennis)

07.01.2023 to 06.31.2027

Machine Learning for Ventricular Arrhythmias

N/A

University of Florida/Edgewise Therapeautics, Inc. (PI Ennis)

06.01.2024 to 06.01.2026

A Phase 2 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of EDG-5506 on Safety, Biomarkers, Pharmacokinetics, and Functional Measured in Adults and Adolescents with Becker Muscular Dystrophy (“Study’)

N/A

National Science Foundation (PI Ennis)

09.01.2022 to 08.31.2026

Collaborative Research: SCH: Quantifying Cardiac Performance by Measuring Myofiber Strain with Routine MRI

The objectives of this proposal are: 1) Computing myofiber strains in healthy volunteers from MRI data routinely acquired in the clinic; 2) Quantify patient specific uncertainty in myofiber strain predictions based on imaging data noise and model assumptions. 3) Characterize cardiac function in patients affected by aortic stenosis by measuring myofiber strains; 4) Accelerate transition to practice by deploying the proposed framework as a cloud computing platform.

NIH/NHLBI/R01 HL152256 (PI Ennis)

06.24.2020 to 05.31.2025

Using Atrial Mechanics to Identify Fibrosis in Patients with Atrial Fibrillation

We propose to use magnetic resonance imaging (MRI) of atrial mechanics to identify localized fibrosis and hypothesize that attenuated mechanics provide a robust measure of atrial fibrosis.

University of Florida/REGENXBIO Inc./RGX-202-1101 (PI Ennis)

07.18.2023 to 12.30.2024

A Phase 1-2 Open-label, Dose Escalation and Dose Expansion Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of Intravenous RGX-202 Gene Therapy in Males with Duchenne Muscular Dystrophy (DMD)

The major goal is to evaluate the safety and efficacy of a new therapy for treating boys with DMD. 

ARPA-H/1AY1AX000002-01 (PI Skylar-Scott, Co-I Ennis)

09.25.2023 to 09.24.2028

Health Enabling Advancements through Regenerative Tissue Printing (HEART)

The goal of this project is to integrate automated and organ-scale biomanufacturing capacity, entirely new and rapid 3D collaborative printing robots, and continuous layer-free bioprinters for rapid-production of complex tissue models to begin the era of organ biofabrication. 

Link to NIH Reporter

NIH/NHLBI K99-R00 HL087614 [2008-2012]  

Myocardial structure, function, and remodeling in mitral regurgitation

Pilot Project under NIH/NIAMS P30AR057230 (PI Spencer) [2012-2013]  
Quantitative Cardiovascular MRI for Pediatric Patients with Duchenne Muscular Dystrophy

AHA 13BGIA14530010 Beginning Grant In Aid [2013-2015]  
Complete Free-Breathing Cardiovascular MRI Exam for Pediatric Patients with Cardiomyopathy

Siemens Medical Solutions, USA [2013-2017]  
Technical Developments for 3T MRI Clinical Applications

NIH/NHLBI R21 HL127433 [2015-2017]  
Are 3T MRI Exams Safe For Patients with Pacemakers and ICDs?

NIH/NHLBI K25 HL135408 [2017-2020]  
Defining and Measuring Diastolic Myocardial Kinematics and Stiffness

AHA 19IPLOI34760294 [2019-2021]  
The Cardiac Connectome for Understanding the Electromechanics of Heart Failure 

NIH/NHLBI R01 HL131975 [2016-2022]  
Validating Cardiac MRI Biomarkers and Genotype-Phenotype Correlations for DMD

NIH/NHLBI R01 HL131823 [2018-2022]  
A New Framework for Understanding the Mechanisms of Diastolic Dysfunction