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Liquid Biopsy With PET/CT Versus PET/CT Alone in Diagnosis of Small Lung Nodules
Recruiting
I'm InterestedTrial ID: NCT05066776
Purpose
The purpose of this study is to determine if a liquid biopsy, a method of detecting cancer
from a blood draw, combined with a PET/CT scan, a type of radiological scan, is better at
determining whether a lung nodule is cancerous when compared to a PET/CT scan alone. A PET/CT
scan is already used for diagnosis of lung nodules, but its efficacy is uncertain in nodules
6-20 mm in size. Therefore, the PET/CT will be evaluated for its diagnostic ability in
lesions this size alone and in combination with a liquid biopsy. Secondarily, a machine
learning model will be created to see if the combination of the PET/CT imaging data and the
liquid biopsy data can predict the presence of cancer.
Official Title
Liquid Biopsy in Combination With PET/CT Versus PET/CT Alone in Diagnosis of Small Lung Nodules
Stanford Investigator(s)
Rajesh Shah
Clinical Associate Professor, Radiology
Millie Das
Clinical Professor, Medicine - Oncology
Sachin Basiq Malik
Clinical Associate Professor, Radiology
Eligibility
Inclusion Criteria:
- Over 18 years of age
- ECOG performance status of 0,1, or 2
- Newly discovered lung nodule with:
1. At least one solid lung nodule measuring 6 mm- 20 mm in greatest diameter
detected on screening CT
2. No single lesion larger than 20 mm in greatest diameter when multiple nodules
present
3. High- or intermediate-risk nodules per American College of Chest Physician (ACCP)
guidelines
- Able to provide informed consent
Exclusion Criteria:
- Prior cancer of any type for the previous 3 years
- Prior organ, bone marrow, of hematopoietic stem cell transplant
- Contraindication to administration of [18F]FDG
- Inability to undergo a PET/CT scan
- Ongoing infection, either acute or subacute
- Severe COPD or lung disease requiring home oxygen use
- Pregnancy
Recruiting
I'm InterestedContact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Rajesh Shah, MD
650-493-5000 Ext. 65925