©2024 Stanford Medicine
Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
Recruiting
I'm InterestedTrial ID: NCT03827694
Purpose
This study will establish a non-invasive diagnostic approach and evaluate clinical outcomes
for children at high-risk for pulmonary invasive fungal infection (PIFI).
Official Title
Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
Stanford Investigator(s)
Eligibility
Inclusion Criteria:
- Males or females age > 120 days and < 22 years at any participating site
- Have at least one of the following conditions associated with a known high incidence
of IFI: hematopoietic stem cell transplantation (HSCT), aplastic anemia, bone marrow
failure, primary or acquired immune deficiency, or malignancy
- New (last 96 hours) radiographic evidence of at least one of the following: at least
one nodular lesion greater than or equal to 5 mm in size, a wedge-shaped and segmental
or lobar consolidation, a cavitary lesion, a lesion with a halo sign, a lesion with a
reverse halo sign, or a lesion with an air crescent sign
- Prolonged neutropenia (absolute neutrophil count < 500 cells/µl for a period of ≥ 5
consecutive days) in 30 days prior to and including the day of qualifying chest MRI or
CT scan date OR currently receiving systemic therapy for acute or chronic
graft-versus-host disease (GVHD) OR presence of neutrophil dysfunction because of
underlying acquired or primary immune deficiency (e.g. chronic granulomatous disease)
on the date of the qualifying chest MRI or CT scan
- Subject consent or parental/guardian permission (informed consent) and if appropriate,
child assent
Exclusion Criteria:
- Weight <3 kg, so as to not exceed 3 ml/kg in a single blood draw
- Previous inclusion in this study
Intervention(s):
diagnostic test: Non-Invasive Testing for PIFI
Recruiting
I'm InterestedContact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Angelee Vaid
510-940-3376