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Treatment of Disruptive Behaviors in Fragile X Syndrome
Not Recruiting
Trial ID: NCT03510156
Purpose
Disruptive behaviors such as self-injury, aggression, and property destruction pose
significant health-related issues to children diagnosed with fragile X syndrome (FXS),
impacting the child's quality of life and causing significant distress to families.
Access to appropriate treatment for families is severely limited by factors such as cost of
care, shortages of qualified treatment providers, and geographic spread of children with FXS
across the country. To address these potential issues, the effectiveness of administering a
standardized function-based behavioral treatment for problem behaviors in FXS will be
evaluated using telemedicine. The proposed study intervention therefore offers a tremendous
step forward in clinical research both in the field of FXS and in the field of developmental
disabilities more broadly, and thus will have a significant impact on public health.
Official Title
Treatment of Disruptive Behaviors in Fragile X Syndrome
Eligibility
Inclusion Criteria:
1. Child has a confirmed diagnosis of FXS (>200 CGG repeats on the FMR1 gene with
evidence of aberrant methylation)
2. Child is male, between the ages of 3-10 years old
3. Child is reported to show self-injury, property destruction and/or aggression on at
least a daily basis
4. The caregiver agrees to keep any therapies that the child receives (i.e., medications
or other treatments) as stable as possible throughout involvement in the study
5. The family has a high-speed internet connection at home or lives in an area with 4G
network coverage
6. Availability for one-hour daily telemedicine treatment sessions
7. Availability for in-home assessment totaling 8 hours across two consecutive days
Exclusion Criteria:
1. The child or caregiver has significant sensory impairments (e.g., blindness or
deafness)
2. Non-English speaking
3. The child receives Applied Behavior Analysis services in excess of five hours per week
4. The child has a significant neurological condition (e.g., frequent seizures, brain
injury, Tourette's syndrome) that would preclude participation
5. The child or caregiver has significant mobility issues
6. The child is currently participating in another research study that would preclude
participation in the study
Intervention(s):
behavioral: Behavior analytic treatment
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Katerina Monlux, MA
650-422-1032