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PRIME Care (PRecision Medicine In MEntal Health Care)
Not Recruiting
Trial ID: NCT03170362
Purpose
The focus of this application is on the impact of providing depressed Veterans and their
providers with the results of pharmacogenetic (PGx) testing for psychotropic medications. The
project focuses on whether and how patients and providers use genetic test results given to
them at the time an antidepressant is to be initiated to treat Major Depressive Disorder
(MDD) and whether use of the test results improves patient outcomes. MDD is one of the most
common conditions associated with military service and combat exposure, increases suicide
risk, and worsens the course of common medical conditions, making it a leading cause of
functional impairment and mortality. Validation of a PGx test to personalize the treatment of
MDD represents an important opportunity to improve the healthcare of Veterans.
Official Title
PRIME Care (PRecision Medicine In MEntal Health Care)
Stanford Investigator(s)
Trisha Suppes, MD, PhD
Professor of Psychiatry and Behavioral Sciences (Public Mental Health and Population Sciences)
Eligibility
Inclusion Criteria:
- PHQ-9 score 10 and a presumptive diagnosis of MDD per PHQ-9 criteria
- at least one prior treatment exposure for MDD (psychotherapy or antidepressant
- intent to start treatment of the MDD with an antidepressant, simple dose increases
will not be considered inclusionary
- willingness to provide signed, informed consent to participate in the study
Exclusion Criteria:
- current serious co-occurring psychiatric illness, i.e.:
- schizophrenia
- bipolar disorder
- psychotic major depression
- borderline or antisocial personality disorder
- eating disorder
- active alcohol or other drug use disorder
- current use of an antipsychotic medication
- augmentation therapy, e.g.:
- use of two or more antidepressants at the time of randomization (trazodone at a
dosage < 150 mg/day will not be considered augmentation and thus allowed)
- patients requiring urgent care or inpatient hospitalization at the time of consent
- currently incarcerated
Intervention(s):
other: Pharmacogenetic Test
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
E. Grace Fischer
(650) 444-8983