Investigation of Tipifarnib in Treatment of Subjects With PTCL That Have Not Responded to Standard Therapy.

Inclusion Criteria:

   1. Diagnosis of PTCL according to the most recent edition of the World Health
   Organization (WHO) Classification of Tumors of Hematopoietic or Lymphoid Tissues, as
   follows:

      1. Anaplastic large cell lymphoma (ALCL), ALK positive

      2. ALCL, ALK negative

      3. Angioimmunoblastic T-cell lymphoma (AITL)

      4. Enteropathy-associated T-cell lymphoma

      5. Extranodal natural killer (NK) T-cell lymphoma, nasal type

      6. Hepatosplenic T-cell lymphoma

      7. Peripheral T-cell lymphoma, not otherwise specified (NOS)

      8. Subcutaneous panniculitis-like T-cell lymphoma

   2. For enrollment into the AITL expansion cohort, subjects must have the diagnosis of
   AITL, nodal PTCL with T-follicular helper phenotype or follicular PTC.

   3. For enrollment into the CXCL12+ PTCL expansion cohort, subjects must have the
   diagnosis of PTCL (a - h subtypes listed above, except AITL), consent to provide
   buccal swabs for CXCL12 SNP testing, and be found to be CXCL12+ based on testing by a
   Sponsor approved methodology.

   4. Relapsed or are refractory to at least 1 prior systemic cytotoxic therapy. -Subjects
   must have received conventional therapy as a prior therapy.

   5. Subject has consented to provide at least 6 unstained tumor slides (10 preferred) or
   an FFPE block for biomarker testing.

   6. Subject has measurable disease as determined by the Lugano Classification and/or
   mSWAT.

   7. At least 2 weeks since the last systemic therapy regimen prior to enrollment.

   8. At least 2 weeks since last radiotherapy if radiation was localized to the only site
   of measurable disease, unless there is documentation of disease progression of the
   irradiated site. Subjects must have recovered from all acute toxicities from
   radiotherapy.

   9. ECOG performance status of 0-2

10. Acceptable liver and renal function

11. Acceptable hematologic status

12. Female subjects must be either:

      1. Of non-child-bearing potential (surgically sterilized or at least 2 years post-
      menopausal); or

      2. If of child-bearing potential, subject must use an adequate method of
      contraception consisting of two-barrier method or one barrier method with a
      spermicide or intrauterine device. Both females and male subjects with female
      partners of child- bearing potential must agree to use an adequate method of
      contraception for 2 weeks prior to screening, during, and at least 4 weeks after
      last dose of trial medication. Female subjects must have a negative serum or
      urine pregnancy test within 72 hours prior to start of trial medication.

      3. Not breast feeding at any time during the study.

13. Written and voluntary informed consent.

Exclusion Criteria:

   1. Diagnosis of any of the following:

      1. Precursor T-cell lymphoma or leukemia

      2. Adult T-cell lymphoma/leukemia (ATLL)

      3. T-cell prolymphocytic leukemia

      4. T-cell large granular lymphocytic leukemia

      5. Primary cutaneous type anaplastic large cell lymphoma

      6. Mycosis fungoide/Sezary syndrome

   2. Ongoing treatment with an anticancer agent not contemplated in this protocol.

   3. Prior treatment (at least 1 full treatment cycle) with an FTase inhibitor.

   4. Any history of clinically relevant coronary artery disease or myocardial infarction
   within the last 3 years.

   5. Known central nervous system lymphoma.

   6. Stem cell transplant less than 3 months prior to enrolment.

   7. Non-tolerable > Grade 2 neuropathy or evidence of unstable neurological symptoms
   within 4 weeks of Cycle 1 Day 1.

   8. Major surgery, other than diagnostic surgery, within 2 weeks prior to Cycle 1 Day 1,
   without complete recovery.

   9. Other active malignancy requiring therapy such as radiation, chemotherapy, or
   immunotherapy.

10. Active, uncontrolled bacterial, viral, or fungal infections, requiring systemic
   therapy.

   Known infection with HIV, or an active infection with hepatitis B or hepatitis C.

11. Subjects who have exhibited allergic reactions to tipifarnib, or structural compounds
   similar to tipifarnib or to its excipients. This includes hypersensitivity to
   imidazoles, such as clotrimazole, ketoconazole, miconazole and others in this drug
   class.

12. Concomitant disease or condition that could interfere with the conduct of the study,
   or that would, in the opinion of the investigator, pose an unacceptable risk to the
   subject in this study.

13. The subject has legal incapacity or limited legal capacity.

14. Dementia or significantly altered mental status that would limit the understanding or
   rendering of informed consent and compliance with the requirements of this protocol.

15. Unwillingness or inability to comply with the study protocol for any reason.