Feasibility 3D Perfusion Ultrasound for Liver Cancer SABR Planning and Response Evaluation

Inclusion Criteria:

   - Ability to understand and willingness to sign the written informed consent document

   - Patient with primary liver tumor or metastasis scheduled for Stereotactic Ablative
   Radiotherapy (SABR)

   - Patient is at least 18 years of age. No gender/race-ethnic restrictions.

   - Performance status (ECOG) between 0-3

   - History and Physical done within 4 weeks of enrollment.

Exclusion Criteria:

   - Patient has previously been enrolled in and completed this study.

   - Known right to left cardiac shunt, bidirectional or transient.

   - Patient has any medical condition or other circumstances which would significantly
   decrease the chances of obtaining reliable data, achieving study objectives, or
   completing the study and/or post-dose follow-up examinations.

   - History of hypersensitivity to the contrast agent perflutren

   - History of pulmonary hypertension

   - Patients who are pregnant or are trying to become pregnant