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A Pivotal Study to Evaluate the Effectiveness and Safety of ExAblate Transcranial MRgFUS Thalamotomy Treatment of Medication Refractory Essential Tremor Subjects

The objective of this prospective, randomized, double-blind (to subjects, local site's blinded assessor and Tremor Core Lab assessors), crossover, multi-site, two-arm study (ExAblate treated arm Vs ExAblate Sham treated control arm) is to test the efficacy of treatment using the ExAblate Transcranial System and to further demonstrate safety in medication-refractory tremor in subjects with essential tremor (ET).

Stanford is not currently accepting new patients for this trial. You may want to check to see if other locations are recruiting.



  • device : Sham Transcranial ExAblate
  • device : Transcranial ExAblate

Phase: N/A


Ages Eligible For Study:

22 Years - N/A

Inclusion Criteria

- Men and women, age 22 years and older - Subjects who are able and willing to give informed consent and able to attend all study visits - Subjects with a diagnosis of Essential Tremor as confirmed from clinical history and examination by a neurologist or neurosurgeon specialized in movement disorder - Subject exhibits a significant disability from their ET despite medical treatment - Subjects should be on a stable dose of all ET medications for 30 days prior to study entry - Subject is able to communicate sensations during the ExAblate Transcranial procedure

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Contact information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Jennifer Lillian Marcellus
Not Recruiting

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