Primary Sclerosing Cholangitis With Oral Vancomycin by the Study of Its Antimicrobial and Immunomodulating Effects

Inclusion Criteria:

   - PSC Diagnosis: Liver biopsy and/or imaging (MRCP, ERCP, CT, or US

   - Colonoscopy within 1 year or starting of study

   - 2 groups:

      1. IBD (Inflammatory bowel disease) and PSC: details of extent and type of IBD

      2. No IBD and PSC, but positive p-ANCA or ASCA serologies indicating possible IBD.

Exclusion Criteria:

   - Allergy to Vancomycin

   - PSC not associated with IBD or NO positive IBD antibodies (p-ANCA [anti- neutrophil
   cytoplasmic antibody] or ASCA [anti-Saccharomyces cerevisiae antibody])

   - Cholangiocarcinoma

   - On oral or topical (enemas or suppositories) corticosteroids,topical mesalamine, or
   biologics (infliximab, adalimumab, certolizumab).