Adiponectin Polymorphisms, Insulin Resistance, and Pharmacokinetics in Obesity
The primary objective of this study is to determine the influence of insulin resistance on drug metabolism and response in obese subjects. The investigators hypothesize that expression of adiponectin (a hormone secreted by fat tissue), and specific variants in the adiponectin gene can predict the insulin resistance and drug response among obese subjects.
- drug : Propofol and Fentanyl administration
Ages Eligible For Study:
- Inclusion criteria include patients of adult age - American Society of Anesthesiologists Class I, II, or III, and undergoing elective surgical procedures requiring general anesthesia - Body mass index greater than 35