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Feasibility Study of Exercises for Myeloablative Allogeneic Blood and Marrow Transplantation (BMT) Patients
Not Recruiting
Trial ID: NCT01396031
Purpose
Blood and marrow transplantation (BMT) is commonly used in the treatment of oncologic and
hematologic disorders. Patients undergoing Hematopoietic stem cell transplantation (HSCT) are
screened for functional status among other criteria to ensure that they are able to endure
the rigorous treatment involved during Hematopoietic stem cell transplantation (HSCT). The
patient entering the transplant process is possibly already functionally compromised from
their disease, prior cancer treatment, and possible other co-morbidities. Additional factors
of the transplantation that compromise the independent functional status of the patient
include the high dose preparative regimen, pancytopenia, steroid-related side effects,
hospitalization, transplantation complications such as infections, pulmonary alterations,
acute and chronic Graft-versus-host Disease (GVHD), pain, decreased nutritional input, and
other sequelae of transplantation.
Physical Therapy has been utilized in this population primarily as a supportive therapy to
prevent and limit the patient's functional decline. Studies have addressed general and
aerobic exercise in this population but there is a paucity of research investigating the
benefits of a strength-training program, particularly performed in weight-bearing, in
attenuating the detrimental effects of the transplantation on functional status.
This is a feasibility study questioning if an exercise program including weight-bearing
strengthening exercises and cardiovascular exercise is practical for the patients to carry
out as inpatients. The study will also preliminarily determine if this exercise program
influences functional outcomes and level of fatigue. Such outcome measures will include 1)
FiveTimes Sit-To-Stand Test, 2) Six-Minute Walk Test, 3) stair performance, 4) Functional
Assessment of Cancer Therapy-Bone Marrow Transplantation (FACT-BMT) and Functional Assessment
of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) Scales.
The study population will include patients with lymphomas and acute leukemias undergoing
matched-related donor allogeneic myeloablative Blood and marrow transplantation (BMT).
Official Title
Matched-Status Exercise Program in Patients Undergoing Myeloablative Allogeneic Blood and Marrow Transplantation: A Feasibility Study
Eligibility
Inclusion Criteria:
- All diagnoses admitted for a first allogeneic myeloablative Blood and marrow
transplantation (BMT)
- Adult subjects greater or equal to 18 year of age. There are no gender or ethnic
restrictions
- Karnofsky performance status >= 70%.
- Admitted to E1 Day-7 (+/- 3 days).
- Patients must be informed of this study and must sign and give written informed
consent in accordance with institutional and federal guidelines.
Exclusion Criteria:
- Patients with musculoskeletal, neurological, cardiovascular, and pulmonary impairments
will be excluded. Cardiovascular and pulmonary status will be confirmed prior to
transplantation by electrocardiogram, echocardiogram, and pulmonary function tests.
Musculoskeletal and screening for neurological impairments will be assessed by
Karnovsky score >=70% and by Physical Therapy assessment.
Intervention(s):
behavioral: Physical Therapy
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Grace Lu
6507236701