Effect of Celecoxib on Perioperative Inflammatory Response in Colon Cancer

Inclusion Criteria:

- Colon cancer patients with no evidence of metastasis in distant organs (i.e., TNM stage
I-III), who are

   - between 18 and 75 years old,

   - have a body mass index (BMI) between 18 and 35 kg/m^2,

   - and are eligible for laparoscopically-assisted colectomy for primary tumor resection.

   - Patients must have the ability to understand and the willingness to sign a written
   informed consent document.

Exclusion Criteria:

- A history of allergic-type reactions to celecoxib or sulphonamides,

   - a history of asthma, skin reactions or other allergic reactions to aspirin or other
   NSAIDs,

   - a history of thromboembolic event (cerebrovascular accident, transient ischemic
   attack,

   - unstable angina, myocardial infarction, deep vein thrombosis, or pulmonary embolism),

   - renal insufficiency (defined by a serum creatinine level > 1.5 mg/dL or blood urea
   nitrogen level > 22 mg/dL),

   - active gastrointestinal bleeding in the 60 days before surgery,

   - alcohol or drug abuse, and

   - previous chemotherapy or abdominal/pelvic radiation therapy.

   - After randomization, other exclusion criteria will include a surgical procedure longer
   than 6 h, inability to extubate the trachea within 4 h after operation, evidence of a
   new postoperative myocardial infarction, abnormal postoperative mental status or any
   new neurologic deficit, significant postoperative bleeding (with a hemoglobin level <
   7.5 g/dL), requiring blood transfusion, or a urine output of less than 30 mL/h.