Sirolimus and Mycophenolate Mofetil as GVHD Prophylaxis in Myeloablative, Matched Related Donor Hematopoietic Cell Transplantation

GVHD prophylaxis of sirolimus and mycophenolate mofetil for patients undergoing matched related allogeneic transplant for acute and chronic leukemia, MDS, high risk NHL and HL

Stanford is not currently accepting new patients for this trial. You may want to check clinicaltrials.gov to see if other locations are recruiting.

Investigator(s):

Intervention(s):

  • drug : Sirolimus
  • drug : Mycophenolate Mofetil
  • drug : cyclophosphamide
  • drug : VP-16
  • drug : Carmustine

Phase: Phase 2

Eligibility

Ages Eligible For Study:

2 Years - 60 Years

Inclusion Criteria

- Disease Categories (participants will have one of the following) - AML, age 2 - 60 years beyond 2nd remission or relapsed/refractory disease - AML, age 51-60 years of age, in first or subsequent remission or relapsed/refractory disease - AML with multilineage dysplasia - ALL, age 2 - 60 years beyond 2nd remission or relapsed/refractory disease - ALL, age 51 - 60 years in first or subsequent remission or relapsed/refractory disease - CML Beyond 2nd chronic phase or in blast crisis - MDS; Includes World Health Organization classifications of refractory anemia with excess blasts-1 (RAEB-1), RAEB-2 and therapy-related MDS - Myeloproliferative disorders; MDS with poor long-term survival including myeloid metaplasia and myelofibrosis - High risk NHL in first remission - Relapsed or refractory NHL - HL beyond first remission - Males and females of any ethnic background 2 - 60 years of age - Karnofsky Performance Status >= 70% or Lansky performance status > 70% for patients < 16 years of age. - Matched related donor identified - 6/6 HLA-A, B and DRB1 - Willingness to take oral medications during the transplantation period - Ability to understand and the willingness to sign a written informed consent document

External Links

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Contact information

Primary Contact:

BMT Referrals 6507230822

Stanford University School of Medicine 300 Pasteur Drive Stanford, CA 94305

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