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Stanford Accelerated Recovery Trial (START)
Not Recruiting
Trial ID: NCT01067144
Purpose
The goal of this study is to determine whether administering Gabapentin prior to surgery
affects duration of pain and opioid use post-surgery. The investigators aim to compare
gabapentin to placebo in a prospective, randomized clinical trial in which patients will be
followed post-surgery until pain resolves and opioid use ceases.
Official Title
Stanford Accelerated Recovery Trial (START)
Stanford Investigator(s)
Ian Carroll, MD, MS
Associate Professor of Anesthesiology, Perioperative and Pain Medicine (Adult Pain)
Peter Schmidt
Clinical Assistant Professor, Anesthesiology, Perioperative and Pain Medicine
Eligibility
INCLUSION CRITERIA
- Age 18 to 75
- Undergoing a scheduled surgery
- English speaking
- Ability and willingness to complete questionnaires or use Palm Pilot
EXCLUSION CRITERIA
- Known kidney disease
- Currently receiving gabapentin or (pregabalin) lyrica already
- Cognitive impairment
- Previous history of excessive sedation or adverse reaction to gabapentin (not it was
tried but ineffective for nerve pain)
- Coexisting chronic pain > 4/10 disorder in area other than surgical target
- Plan to move out of state
- Condition that would in judgment of team member make patient likely to be lost to
follow-up
- Elevated suicidality
- Known pregnancy
- Current symptoms of ataxia, dizziness, or sedation
- Narrow angle glaucoma
- Severe respiratory insufficiency (ie, severe emphysema or chronic obstructive
pulmonary disease)
- History of gastric bypass surgery and obstructive sleep apnea requiring continuous
positive airway pressure (CPAP)
Intervention(s):
drug: Gabapentin
drug: Lorazepam (active control)
drug: Placebo (inactive)
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
ccto-office@stanford.edu
650-498-7061