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Effects of Growth Hormone on Cognition and Cerebral Metabolism in Adults

Patients with Growth hormone (GH) deficiency often report impaired quality of life and difficulty with mental functioning. It has been suggested that GH replacement in such patients leads to improvement in cognitive function. The aim of this study is to elucidate the effects of GH replacement in patients with GH deficiency on cognitive function using structural and functional neuroimaging and cognitive testing.

Stanford is now accepting new patients for this trial.



  • drug : Human Growth hormone - nutropin

Phase: N/A


Ages Eligible For Study:

18 Years - 65 Years

Inclusion Criteria

- Ability to provide written informed consent and comply with study assessments for the full duration of the study - Age 18-65 years old - Both men and women - Naive to GH replacement therapy - Diagnosis of Growth Hormone deficiency, adult onset - Good general health - Normal thyroid, adrenal or gonadal function, or stable thyroid, glucocorticoid (at replacement doses) and gonadal replacement therapy for at least 3 months prior to study initiation. If subjects are receiving transdermal testosterone, attainment of mid-normal serum values will be considered adequate. If subjects are on intramuscular testosterone, attainment of mid-normal serum testosterone at mid-injection cycle will be considered adequate

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Contact information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Laurence Katznelson, MD

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