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A Phase I, Open-Label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of Ascending Doses of AZD4547 in Patients With Advanced Solid Malignancies

This study is primarily designed to assess the safety and tolerability of AZD4547 at increasing doses in patients with advanced solid malignancies and for whom no standard medication options are available. It also assesses the blood levels and action of AZD4547 in the body over a period of time.

Stanford is not currently accepting new patients for this trial. You may want to check to see if other locations are recruiting.



  • drug : AZD4547
  • drug : AZD4547
  • drug : AZD4547

Phase: Phase 1


Ages Eligible For Study:

25 Years - N/A

Inclusion Criteria

- Minimum life expectancy of 12 weeks - The presence of a solid, malignant tumour that is resistance to standard therapies or for which no standard therapies exist - In the expansion for the study patients must have a tumour at least 1cm in size that can be measure using a CT or MRI scan, and provide a tumour sample to the sponsor company for testing of FGFR1 and/or 2 amplification - Expansion, 5 groups of advanced cancer - Solid tumours,FGFR1 and/or FGFR2 gene amplified - Squamous NSCLC, FGFR1 gene low & high amplified - Gastric adenocarcinoma, including the lower oesophagus/gastro-oesophageal junction, FGFR2 gene low & high amplified - Aged at least 25 years

External Links

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Contact information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Cancer Clinical Trials Office
Not Recruiting

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