Functional MRI Before and After Treatment for Depression

Inclusion Criteria:

Patients will be aged 18-65, have no significant neurologic history, must meet DSM-IV
criteria for a diagnosis of major depression and be free of antidepressant or other
psychotropic medication for a minimum of two weeks before enrollment. If a subject is
talking psychiatric medication he/she may be weaned off of the medication by their treating
physician prior to study enrollment. Such a course of action would only be advised if the
current medication was not considered to be of any benefit to the subject. In particular,
if a patient is on antidepressant medication which is of benefit, we would not advise
tapering off medication -- and subsequent risk of relapse -- in order to participate in the
study. The same line of thinking applies to all psychiatric diagnoses and associated
medications candidate subjects may be taking.

Exclusion Criteria:

   1. Significant head trauma with loss of consciousness.

   2. Active abuse of alcohol or illegal substances.

   3. Excluded psychiatric diagnoses include: Bipolar Affective Disorder, primary psychotic
   disorders (Schizophrenia, Schizoaffective disorder), Obsessive-Compulsive Disorder

   4. Pregnant or nursing women.

   5. Any contraindication to being scanned in the 3T scanner at the Lucas Center such as
   having a pacemaker or any implanted device that has not been cleared for scanning at 3
   Tesla.

   6. Any significant neurologic history (i.e. seizure, stroke, multiple sclerosis).

   7. Use of psychotropic medications within 2 weeks of enrollment.