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An Observational Study of Fungal Biomarkers (MK-0000-089)
Not Recruiting
Trial ID: NCT00854607
Purpose
The purpose of this study is to evaluate the relationship between fungal biomarker levels
during anti-fungal therapy and the success of treatment for fungal infection. The primary
hypothesis is that over the initial two weeks of anti-fungal therapy, fungal biomarkers from
participants with invasive aspergillosis (IA) will be lower for those with a successful
clinical outcome compared to those with a failed clinical outcome.
Official Title
A Prospective, Non-Intervention, Observational Assessment of the Correlation Between Circulating Biomarkers of Fungal Bioburden and Clinical Outcome in the Setting of Invasive Aspergillosis
Stanford Investigator(s)
Wes (Janice) Brown
Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy)
Dora Ho
Clinical Professor, Medicine - Infectious Diseases
Eligibility
Inclusion Criteria:
- Is 16 years of age or older
- Female is either post-menopausal, surgically sterilized, willing to use 2 adequate
methods of birth control, or agrees to abstain from heterosexual activity throughout
the study
- Female of child bearing potential must have a negative pregnancy test
- Male is surgically sterilized, agrees to use an adequate method of contraception, or
agrees to abstain from heterosexual activity for the duration of the study
- Has possible, probable, or confirmed invasive aspergillosis (IA)
- Has had a computed tomography (CT) or magnetic resonance imaging (MRI) scan 72 hours
prior to initiation of anti-fungal therapy
Exclusion Criteria:
- Has had hemodialysis using cellulose membrane within 2 weeks of study start
Intervention(s):
other: No Intervention
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
BMT Referrals
650-723-0822