Sex Differences in Symptomatic Non-Obstructive Coronary Disease: Do Women Have a Unique Coronary Pathophysiology?

This is a research study evaluating possible causes of chest pain (or an anginal equivalent, such as fatigue resulting in a decrease in exercise tolerance, shortness of breath, or back, shoulder, neck, or jaw pain) in people with no evidence of significant coronary artery disease on their coronary angiogram (pictures of the blood vessels in the heart). The purpose of the research study is to determine if there is diffuse atherosclerosis (plaque) not appreciated by angiography, or if the coronary endothelium (lining of the blood vessels in the heart) and/or microcirculation (small vessels in the heart that are not easily seen with an angiogram) are not functioning properly in those who have chest pain (or an anginal equivalent), but normal coronary arteries on angiography. Specifically, we are interested if these findings are more common in women than men.

Stanford is now accepting new patients for this trial. Please contact Homa Tavana at 650-721-5540 for more information.



  • procedure : 30 cc blood draw
  • procedure : Intravascular ultrasound (IVUS)
  • procedure : Procedure: Procedure: Coronary pressure/flow testing: Adenosine challenge
  • procedure : Coronary pressure/flow testing: Acetycholine challenge
  • procedure : Procedure: Coronary pressure/flow testing: Nitroglycerin challenge
  • procedure : Coronary pressure/flow wire testing

Phase: N/A


Ages Eligible For Study:

18 Years - N/A

Inclusion Criteria

1. Patient referred for elective coronary angiography because of a reasonable clinical suspicion of coronary ischemia. 2. Presence of angina or an anginal equivalent (including chest, back, shoulder, arm, neck, jaw discomfort, or shortness of breath brought on by physical exertion, emotional stress, or certain times of day/month).

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Contact information

Primary Contact:

Homa Tavana 650-721-5540

Stanford University School of Medicine 300 Pasteur Drive Stanford, CA 94305

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