Effect of IV Lidocaine Infusions on Pain
Our goals for this study involve using intravenous lidocaine as it is normally used in the Stanford Pain Management Center to assess the effect of intravenous lidocaine on chronic pain. Studies have been done determining the efficacy of intravenous lidocaine for treating pain but little research has been done to determine the effects of an intravenous lidocaine infusion on the different components of the pain experience. Our study will incorporate psychophysical and behavioral testing both before and during the infusions of lidocaine to determine changes in mood. In addition, we will use functional magnetic resonance imaging to observe what changes occur in the brain during a lidocaine infusion.
Stanford is not currently accepting new patients for this trial. You may want to check clinicaltrials.gov to see if other locations are recruiting.
- drug : Intravenous lidocaine
Ages Eligible For Study:
- subjects between the ages of 18 and 100 years for clinical component; subjects between the ages of 18 and 70 for the MRI component - meets the study criteria of chronic pain of either peripheral or central origin - male or a non-pregnant, non-lactating female. If females are of reproductive potential (i.e., not surgically sterilized and/or not post menopausal), they must be practicing an accepted method of birth control, agree to a urine pregnancy test at the start of each study session (for patient scheduled through the clinic, this has already been addressed by the recommending physician) - is not currently on a sodium channel blocking agent, anticonvulsant, or tricyclic antidepressant, - must be able to comply with any other study requirements and complete experimental tasks - have no reported substance abuse within the past six months;
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