Subcutaneous Botulinum Toxin for Cutaneous Allodynia
Superficial injection of Botulinum toxin has been advocated for cosmetic purposes but has also been reported to be helpful for some pain conditions. The investigators have observed prolonged profound analgesia following subcutaneous superficial injection of Botulinum Toxin Type A (BTA) in patients with certain types of neuropathic pain. The investigators propose to study if addition of BTA extends pain relief compared to placebo when injected subcutaneously into areas of cutaneous allodynia (the property that a normally non-noxious stimulus is perceived as painful).
Stanford is not currently accepting new patients for this trial. You may want to check clinicaltrials.gov to see if other locations are recruiting.
- drug : Placebo - Saline
- drug : Botulinum Toxin A
Ages Eligible For Study:
- Moderate to severe pain (greater than 4/10) of duration more than 6 months despite previous therapy. - The patient exhibits at least 80% pain relief following injection of local anesthetic subcutaneously into scar as assessed by change in NRS - The patient reports the presence of hyperalgesia, allodynia, dysesthesia, or hypoesthesia surrounding the scar - Age 18-100 - Ability to read, write, and converse in English, provide informed consent, and follow study procedures