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Efficacy of XL184 (Cabozantinib) in Advanced Medullary Thyroid Cancer
Not Recruiting
Trial ID: NCT00704730
Purpose
The purpose of this research study is to evaluate the progression-free survival (PFS) with
XL184 as compared with placebo (an inactive substance) in subjects with unresectable, locally
advanced, or metastatic medullary thyroid cancer (MTC). Subjects will be randomized to
receive XL184 or placebo in a 2:1 ratio. XL184 is an investigational drug that inhibits
VEGFR2, MET and RET, kinases implicated in tumor formation, growth and migration.
The Clinical Steering Committee for this study, comprised of study doctors who specialize in
medullary thyroid cancer, has provided guidance regarding the design of the study. The
committee includes: Douglas Ball, MD, Barry Nelkin, PhD, Martin Schlumberger, MD and Steven
Sherman, MD.
Official Title
An International, Randomized, Double-Blinded, Phase 3 Efficacy Study of XL184 Versus Placebo in Subjects With Unresectable, Locally Advanced, or Metastatic Medullary Thyroid Cancer
Stanford Investigator(s)
A. Dimitrios Colevas, MD
Professor of Medicine (Oncology) and, by courtesy, of Otolaryngology - Head & Neck Surgery (OHNS) and of Radiation Oncology (Radiation Therapy)
Harlan Pinto
Associate Professor of Medicine (Oncology) and of Otolaryngology - Head & Neck Surgery
Eligibility
Inclusion Criteria:
- The subject has a histologically confirmed diagnosis of MTC that cannot be removed by
surgery, is locally advanced, or has spread in the body.
- The subject is at least 18 years old.
- The subject has an ECOG (Eastern Cooperative Oncology Group) performance status ≤ 2.
- The subject has documented worsening of disease (progressive disease) at screening
compared with a previous CT scan or MRI image done within 14 months of screening.
- The subject has recovered from clinically significant adverse events (side effects)
due to any other medications that were administered prior to randomization.
- The subject has adequate organ and bone marrow function.
- Subjects who are sexually active (male and female) must agree to use medically
accepted methods of contraception during the course of the study and for 3 months
following discontinuation of study treatments.
- The subject has no other diagnosis of cancer (unless non-melanoma skin cancer, an
early form of cervical cancer, or another cancer diagnosed ≥ 2 years previously) and
currently has no evidence of malignancy (unless non-melanoma skin cancer or an early
form of cervical cancer).
- Female subjects of childbearing potential must have a negative pregnancy test at
screening.
Exclusion Criteria:
- The subject has received prior treatment for their cancer within 4 weeks of
randomization (6 weeks for nitrosoureas or mitomycin C).
- The subject has received radiation to ≥ 25 % of bone marrow.
- The subject has received treatment with other investigational agents (unapproved
therapies) within 4 weeks of randomization.
- The subject has received treatment with XL184.
- The subject has brain metastases or spinal cord compression, unless completed
radiation therapy ≥ 4 weeks prior to randomization and stable without steroid and
without anti-convulsant treatment for ≥ 10 days.
- The subject has a history of clinically significant episodes of vomiting blood or a
recent history of vomiting > 2.5 mL (about 1/2 teaspoon) of red blood.
- The subject has serious illness other than cancer.
- The subject is pregnant or breastfeeding.
- The subject has an active infection requiring ongoing treatment.
- The subject is incapable of understanding and complying with the protocol or unable to
provide informed consent.
Intervention(s):
drug: XL184
drug: Placebo
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Cancer Clinical Trials Office
650-498-7061