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Study of the Effect of Sitagliptin on Glucose (Sugar) Metabolism in Patients With Heart Failure
Not Recruiting
Trial ID: NCT00657280
Purpose
This study will investigate the effects of sitagliptin, a medicine commonly used to treat
type 2 diabetes, on the utilization of glucose by the heart in patients with heart failure
which is not due to heart attacks. We hope to determine whether improving the heart's ability
to use glucose in the blood may help improve the function of the heart as well. If so, this
may suggest that even people who do not have frank diabetes but who do have heart failure may
benefit from using this medication.
This study will also investigate the effect of sitagliptin on the body's use of sugar, and of
the effect of sitagliptin on blood flow to the heart.
Official Title
Effect of Sitagliptin on Insulin Resistance and Myocardial Metabolism in Heart Failure
Stanford Investigator(s)
Eligibility
Inclusion Criteria:
1. Diagnosis of nonischemic dilated cardiomyopathy, current NYHA class I-III congestive
heart failure
2. Treatment with a stable comprehensive heart failure regimen for at least 3 months
(including beta-blockers and ACE-inhibitors or angiotensin receptor blockers unless
intolerant)
3. Age > 18 yrs
Exclusion Criteria:
1. Cardiomyopathy primarily due to one of the following:
1. Ischemic heart disease
2. Primary valvular lesion
3. Hypertrophic cardiomyopathy
2. Cardiac resynchronization within the last 3 months
3. Calculated creatinine clearance <30 ml/min or end-stage renal disease on dialysis.
Creatinine clearance will be determined by the Cockcroft-Gault formula.
4. Diagnosis of diabetes mellitus by:
1. Diabetes previously diagnosed per patient history
2. 2 or more fasting glucose values > 125 mg/dl
5. History of heart transplantation
6. Pregnancy or active breast feeding
7. Hospitalization for decompensated heart failure within 30 days prior to enrollment.
Intervention(s):
drug: Sitagliptin
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Ronald Witteles, MD
650-498-4343