A Phase III Randomized Trial of Chemotherapy With or Without Bevacizumab in Patients With Recurrent or Metastatic Head and Neck Cancer

This randomized phase III trial studies chemotherapy to see how well it works with or without bevacizumab in treating patients with head and neck cancer that has come back (recurrent) or that has spread to other parts of the body (metastatic). Drugs used in chemotherapy, such as docetaxel, cisplatin, carboplatin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, may interfere with the ability of tumor cells to grow and spread. Bevacizumab may also make tumor cells more sensitive to chemotherapy and stop the growth of head and neck cancer by blocking blood flow to the tumor. It is not yet known whether combination chemotherapy is more effective when given with or without bevacizumab in treating patients with head and neck cancer.

Stanford is not currently accepting new patients for this trial. You may want to check clinicaltrials.gov to see if other locations are recruiting.

Investigator(s):

Intervention(s):

  • biological : bevacizumab
  • drug : docetaxel
  • drug : cisplatin
  • drug : fluorouracil
  • drug : carboplatin
  • other : cytology specimen collection procedure
  • other : laboratory biomarker analysis

Phase: Phase 3

Eligibility

Ages Eligible For Study:

18 Years - N/A

External Links

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Contact information

Primary Contact:

Jennifer Wong 650-723-1002

Stanford University School of Medicine 300 Pasteur Drive Stanford, CA 94305

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