Clinical Trials Directory

Phase 2 Trial Oral Enzastaurin in Prostate Cancer Patients Who Have Rising PSA (1) During Hormonal Manipulation and (2) After First-Line Cytotoxic Chemotherapy

The purpose is to see how quickly two different types of prostate cancer patients respond when taking enzastaurin. Cohort 1 - asymptomatic patients with androgen-independent PSA-progressive disease with or without clinical or radiographic evidence of metastatic disease. Cohort 2 - patients with androgen-independent metastatic prostate cancer (documented bone or soft tissue metastases) with rising PSA, clinical, radiographic disease progression following one prior docetaxel-based regimen

Stanford is not currently accepting new patients for this trial. You may want to check to see if other locations are recruiting.



  • drug : Enzastaurin

Phase: Phase 2


Ages Eligible For Study:

18 Years - N/A

Inclusion Criteria

- You are expected to be alive in the 12 weeks. - You are at least 18 years old. - You live close enough to the doctor's office to attend all of your required visits. - You have not been treated with chemotherapy for your prostate cancer (cohort 1). - You have had one prior docetaxel-based chemotherapy regimen (cohort 2). - You have evidence of metastatic prostate cancer with bone or soft tissue disease (cohort 2). - Your organs must be functioning properly.

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Contact information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Denise Haas
Not Recruiting

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