Switching to Duloxetine to Ameliorate SSRI-Induced Sexual Dysfunction

Inclusion Criteria::

   - age 18 - 65 inclusive

   - able to read and understand informed consent

   - informed consent given

   - currently being treated with an SSRI for depression or dysthymia

   - currently suffering from treatment-emergent sexual dysfunction attributable to the
   SSRI

   - have normal safety lab values at screen

   - if currently taking medication to improve sexual performance, willing to discontinue
   the drug for the duration of the study

   - female subjects of child bearing age need to use an acceptable form of birth control
   throughout the study Exclusion Criteria:- being pregnant, breastfeeding, or planning
   to become pregnant within 4 months

   - suffering from psychotic, substance abuse, bipolar, or organic mental disorder, OCD,
   panic disorder, or personality disorder severe enough to interfere with study
   participation

   - suffer from an unstable or serious medical disorder

   - having a medical disorder that could be the cause of the sexual dysfunction

   - taking a medication that is metabolized by hepatic enzyme CYP2D6

   - having used a MAOI within 15 days of proposed start of duloxetine treatment

   - having a known hypersensitivity to duloxetine or any of its ingredients

   - having taken viagra or related drug within 3 months prior to starting SSRI treatment

   - requiring ongoing treatment with a mood stabilizer (anticonvulsant) or antipsychotic
   medication