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Biological CVD Risk Factors in Older Depressed Patients
Not Recruiting
Trial ID: NCT00318864
Purpose
The purpose of this study is to determine if improvements in mood will ameliorate autonomic
dysregulation, HPA dysfunction and typical (e.g. lipids) and atypical risk factors in
depressed patients with elevated cardiovascular risk (CVD). Up to 70, depressed participants
with elevated cardiovascular risk factors were randomized to a cognitive behavioral
intervention (CBT) or a waiting list control (WLC) condition. Twenty non-depressed age and
risk-matched controls will also recruited. Traditional risk factors (e.g. lipids, blood
pressure, heart rate), atypical risk factors (endothelial function, asymmetric
dimethylarginine, C-reactive protein) will be measured pre and post treatment six months
later Subjects will undergo a psychophysiological stress test while cardiovascular physiology
was measured. Salivary cortisol will be measured during the day and during the psychological
stress test. Depressed subjects will be randomized to a 16 week cognitive behavior therapy
intervention or to a wait-list control. It is hypothesized that reduction in mood will be
associated with reduction in typical and atypical risk factors.
Official Title
Stress, the HPA and Health in Aging
Stanford Investigator(s)
Eligibility
Inclusion Criteria:
- age > 55 years, hypertensive or hypercholesterolemic, depressed
Exclusion Criteria:
- suicidal
Intervention(s):
behavioral: Cognitive behavioral therapy
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305