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Surfactant Positive Airway Pressure and Pulse Oximetry Trial
Not Recruiting
Trial ID: NCT00233324
Purpose
This study compared the use of continuous positive airway pressure initiated at birth with
the early administration of surfactant administered through a tube in the windpipe within 1
hour of birth for premature infants born at 24 to 27 weeks gestation. In addition, these
infants within 2 hours of birth, had a special pulse oximeter placed to continuously monitor
their oxygen saturation in two different target ranges (85-89% or 91-95%). This study helped
determine whether or not these two management strategies affect chronic lung disease and
survival of premature infants.
Official Title
Surfactant Positive Airway Pressure and Pulse Oximetry Trial (SUPPORT) in Extremely Low Birth Weight Infants
Eligibility
Inclusion Criteria:
- Infants with a minimal gestational age of 24 weeks 0 days to 27 completed weeks (up to
27 6/7ths) by best obstetrical estimate
- Infants who will receive full resuscitation as necessary, i.e., no parental request or
physician decision to forego resuscitation
- Infants whose parents/legal guardians have provided consent for enrollment, or
- Infants without known major congenital malformations
Exclusion Criteria:
- Any infant transported to the center after delivery
- Infants whose parents/legal guardians refuse consent
- Infants born during a time when the research apparatus/study personnel are not
available
- Infants < 24 weeks 0 days or > 28 weeks 0 days, completed weeks of gestation
Intervention(s):
drug: Surfactant
device: Continuous Positive Airway Pressure (CPAP)
drug: Supplemental oxygen with target saturation of 85 to 89%
drug: Supplemental oxygen with target saturation of 91 to 95%
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Krisa Van Meurs, MD