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A Human In-vivo Model for the Detection of Inflammatory and Nociceptive Biomarkers
Not Recruiting
Trial ID: NCT00186563
Purpose
This study aims to establish a novel approach assisting the rational development of analgesic
and anti-inflammatory drugs. In a first step we will test in healthy human volunteers whether
proteins mediating inflammation and pain can be detected in an experimentally induced
inflammatory skin lesion. Fluids that will be used to detect such proteins will be collected
from the inflamed skin site via small porous catheters. We wish to establish the expression
pattern of different proteins and correlate it with various tests assessing pain.
Official Title
Proof-of-concept Study for Bio-marker Assay Validation in Humans
Stanford Investigator(s)
Martin S. Angst
Professor of Anesthesiology, Perioperative and Pain Medicine
Eligibility
Inclusion Criteria:1. Age between 21-60. 2. Skin type II or III according to the
classification of Fitzpatrick (II: fair skin, always burns, sometimes tans, III: medium
skin, sometimes burns, always tans).
Exclusion Criteria:1. History of a significant
systemic disease, a dermatological disease, bleeding disorder, or chronic pain.
2. Consumption of analgesic drugs. 3. Hypersensitivity to sunlight.
Intervention(s):
procedure: Micro-plasmapheresis
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Martin Angst
6504985109