PET Clinical Production for Trials
Radiochemical detection methods are becoming ubiquitous in the imaging of cancer and other pathologies. Countless radiotracers and radioligands have been developed for positron emissin tomography (PET) imaging and are used to target biological processes in the disease pathway. 18F-fluorodeoxyglucose (FDG) is among the most commonly used radiotracers in cancer detection and is produced at our facility.
For production and research assistants, the routine production of clinical tracers is part of their focus. We produce radiotracers at the Radiochemistry Facility at the Lucas Expansion and in the Nuclear Medicine Clinic at the Stanford Hospital for both human and non-human use in research as well as clinical trials. Our routine clinical tracers are synthesized in custom-made and commercial synthetic modules (i.e. GE TRACERlab modules) housed in lead-shielded cells and are distributed manually or automatically (i.e. Comecer Dorothea) to our imagers. Tracers include 18F-FDG, 68Ga-DOTATATE, 15O-water, and numerous others.
The radiotracers are used for imaging many pathologies, including neuroendocrine tumors (DOTATATE); pulmonary carcinoid tumors and many small cell lung carcinomas (bombesin); Hodgkin's disease, non-Hodgkin's lymphoma, colorectal cancer, breast cancer, melanoma, lung cancer, and Alzheimer’s disease (FDG), among countless others.
|[11C]Raclopride||Dopamine-2 Receptors (D2R)||IND approved|
|[64Cu]Rituximab||CD-20 antigen||IND approved|
|[64Cu]BFAb||CA6+ tumors||IND approved|
|[18F]FDG||Tumor metabolism||ANDA approved|
|[18F]FDOPA||Dopamine transporter||IND approved|
|[18F]FHBG||Tumors expressing HSV1-tk||IND approved|
|[18F]FLT||Tumor cell proliferation||IND approved|
|[18F]Flumazenil||GABA-A receptor||IND approved|
|[18F]FPPRGD2||αvβ3 integrin||IND approved|
|[18F]FSPG||Cystine/glutamate exchanger||IND approved|
|[18F]FTC-146||Sigma-1 Receptor||eIND approved|
|[18F]R01MGF2||αvβ6 integrin||eIND approved|
|Sodium [18F]Fluoride||Bone marrow||ANDA approved|
|[68Ga]DOTATATE||Somatostatin Receptor||IND approved|
|[68Ga]PSMA||Prostate Membrane Antigen||IND approved|
|[13N]Ammonia||Cardiac blood perfusion||ANDA approved|
|[15O]Water||Blood flow||RDRC/IND approved|