The following is a partial list of publications acknowledging or including cEMc staff and resources.
Identification of functionally important domains of human cytomegalovirus gO that act after trimer binding to receptors.
Chin A, Liu J, Jardetzky T, Johnson DC, Vanarsdall A.
PLoS Pathog. 2022 Apr 22;18(4):e1010452. doi: 10.1371/journal.ppat.1010452. eCollection 2022 Apr.
PMID: 35452493
Structural conservation among variants of the SARS-CoV-2 spike postfusion bundle.
Yang K, Wang C, White KI, Pfuetzner RA, Esquivies L, Brunger AT.
Proc Natl Acad Sci U S A. 2022 Apr 19;119(16):e2119467119. doi: 10.1073/pnas.2119467119. Epub 2022 Apr 1.
PMID: 35363556
The tethered peptide activation mechanism of adhesion GPCRs.
Barros-Álvarez X, Nwokonko RM, Vizurraga A, Matzov D, He F, Papasergi-Scott MM, Robertson MJ, Panova O, Yardeni EH, Seven AB, Kwarcinski FE, Su H, Peroto MC, Meyerowitz JG, Shalev-Benami M, Tall GG, Skiniotis G.
Nature. 2022 Apr;604(7907):757-762. doi: 10.1038/s41586-022-04575-7. Epub 2022 Apr 13.
PMID: 35418682
Structure-Based Evolution of G Protein-Biased μ-Opioid Receptor Agonists.
Wang H, Hetzer F, Huang W, Qu Q, Meyerowitz J, Kaindl J, Hübner H, Skiniotis G, Kobilka BK, Gmeiner P.
Angew Chem Int Ed Engl. 2022 Apr 6:e202200269. doi: 10.1002/anie.202200269. Online ahead of print.
PMID: 35385593
Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation.
Glassman CR, Tsutsumi N, Saxton RA, Lupardus PJ, Jude KM, Garcia KC.
Science. 2022 Apr 8;376(6589):163-169. doi: 10.1126/science.abn8933. Epub 2022 Mar 10.
PMID: 35271300
The oxytocin signaling complex reveals a molecular switch for cation dependence.
Meyerowitz JG, Robertson MJ, Barros-Álvarez X, Panova O, Nwokonko RM, Gao Y, Skiniotis G.
Nat Struct Mol Biol. 2022 Mar;29(3):274-281. doi: 10.1038/s41594-022-00728-4. Epub 2022 Mar 3.
Plasticity in ligand recognition at somatostatin receptors.
Robertson MJ, Meyerowitz JG, Panova O, Borrelli K, Skiniotis G.
Nat Struct Mol Biol. 2022 Mar;29(3):210-217. doi: 10.1038/s41594-022-00727-5. Epub 2022 Feb 24.
PMID: 35210615
Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins.
Tsutsumi N, Maeda S, Qu Q, Vögele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC.
Sci Adv. 2022 Jan 21;8(3):eabl5442. doi: 10.1126/sciadv.abl5442. Epub 2022 Jan 21.
PMID: 35061538
Structure and mechanism of the SGLT family of glucose transporters.
Han L, Qu Q, Aydin D, Panova O, Robertson MJ, Xu Y, Dror RO, Skiniotis G, Feng L.
Nature. 2022 Jan;601(7892):274-279. doi: 10.1038/s41586-021-04211-w. Epub 2021 Dec 8.
PMID: 34880492
Cryo-Electron Microscopy Structure and Interactions of the Human Cytomegalovirus gHgLgO Trimer with Platelet-Derived Growth Factor Receptor Alpha.
Liu J, Vanarsdall A, Chen DH, Chin A, Johnson D, Jardetzky TS.
mBio. 2021 Oct 26;12(5):e0262521. doi: 10.1128/mBio.02625-21. Epub 2021 Oct 26.
PMID: 34700375
Lattice micropatterning for cryo-electron tomography studies of cell-cell contacts.
Engel L, Vasquez CG, Montabana EA, Sow BM, Walkiewicz MP, Weis WI, Dunn AR.
J Struct Biol. 2021 Dec;213(4):107791. doi: 10.1016/j.jsb.2021.107791. Epub 2021 Sep 11.
PMID: 34520869
Structure of mitotic chromosomes.
Beel AJ, Azubel M, Matteï PJ, Kornberg RD.
Mol Cell. 2021 Nov 4;81(21):4369-4376.e3. doi: 10.1016/j.molcel.2021.08.020. Epub 2021 Sep 13.
PMID: 34520722
Structural insights into GIRK2 channel modulation by cholesterol and PIP2.
Mathiharan YK, Glaaser IW, Zhao Y, Robertson MJ, Skiniotis G, Slesinger PA.
Cell Rep. 2021 Aug 24;36(8):109619. doi: 10.1016/j.celrep.2021.109619.
PMID: 34433062 Free PMC article.
Structure and mechanism of blood-brain-barrier lipid transporter MFSD2A.
Wood CAP, Zhang J, Aydin D, Xu Y, Andreone BJ, Langen UH, Dror RO, Gu C, Feng L.
Nature. 2021 Aug;596(7872):444-448. doi: 10.1038/s41586-021-03782-y. Epub 2021 Aug 4.
PMID: 34349262 Free PMC article.
Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1.
Tsutsumi N, Qu Q, Mavri M, Baggesen MS, Maeda S, Waghray D, Berg C, Kobilka BK, Rosenkilde MM, Skiniotis G, Garcia KC.
Immunity. 2021 Jul 13;54(7):1405-1416.e7. doi: 10.1016/j.immuni.2021.06.001. Epub 2021 Jul 2.
PMID: 34216564
Asymmetric activation of the calcium-sensing receptor homodimer.
Gao Y, Robertson MJ, Rahman SN, Seven AB, Zhang C, Meyerowitz JG, Panova O, Hannan FM, Thakker RV, Bräuner-Osborne H, Mathiesen JM, Skiniotis G.
Nature. 2021 Jul;595(7867):455-459. doi: 10.1038/s41586-021-03691-0. Epub 2021 Jun 30.
PMID: 34194040
G-protein activation by a metabotropic glutamate receptor.
Seven AB, Barros-Álvarez X, de Lapeyrière M, Papasergi-Scott MM, Robertson MJ, Zhang C, Nwokonko RM, Gao Y, Meyerowitz JG, Rocher JP, Schelshorn D, Kobilka BK, Mathiesen JM, Skiniotis G.
Nature. 2021 Jul;595(7867):450-454. doi: 10.1038/s41586-021-03680-3. Epub 2021 Jun 30.
PMID: 34194039
Gold nanoparticles and tilt pairs to assess protein flexibility by cryo-electron microscopy.
Jagota M, Townshend RJL, Kang LW, Bushnell DA, Dror RO, Kornberg RD, Azubel M.
Ultramicroscopy. 2021 Aug;227:113302. doi: 10.1016/j.ultramic.2021.113302. Epub 2021 May 4.
PMID: 34062386
High-resolution view of HIV-1 reverse transcriptase initiation complexes and inhibition by NNRTI drugs.
Ha B, Larsen KP, Zhang J, Fu Z, Montabana E, Jackson LN, Chen DH, Puglisi EV.
Nat Commun. 2021 May 4;12(1):2500. doi: 10.1038/s41467-021-22628-9.
PMID: 33947853 Free PMC article.
Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10.
Saxton RA, Tsutsumi N, Su LL, Abhiraman GC, Mohan K, Henneberg LT, Aduri NG, Gati C, Garcia KC.
Science. 2021 Mar 19;371(6535):eabc8433. doi: 10.1126/science.abc8433.
PMID: 33737461
Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells.
Glassman CR, Mathiharan YK, Jude KM, Su L, Panova O, Lupardus PJ, Spangler JB, Ely LK, Thomas C, Skiniotis G, Garcia KC.
Cell. 2021 Feb 18;184(4):983-999.e24. doi: 10.1016/j.cell.2021.01.018.
PMID: 33606986 Free PMC article.
Mediator structure and conformation change.
Zhang H, Chen DH, Mattoo RUH, Bushnell DA, Wang Y, Yuan C, Wang L, Wang C, Davis RE, Nie Y, Kornberg RD.
Mol Cell. 2021 Apr 15;81(8):1781-1788.e4. doi: 10.1016/j.molcel.2021.01.022. Epub 2021 Feb 10.
PMID: 33571424
The N-terminus of varicella-zoster virus glycoprotein B has a functional role in fusion.
Oliver SL, Xing Y, Chen DH, Roh SH, Pintilie GD, Bushnell DA, Sommer MH, Yang E, Carfi A, Chiu W, Arvin AM.
PLoS Pathog. 2021 Jan 7;17(1):e1008961. doi: 10.1371/journal.ppat.1008961. eCollection 2021 Jan.
PMID: 33411789 Free PMC article.
Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6.
Gao Y, Eskici G, Ramachandran S, Poitevin F, Seven AB, Panova O, Skiniotis G, Cerione RA.
Mol Cell. 2020 Oct 15;80(2):237-245.e4. doi: 10.1016/j.molcel.2020.09.013. Epub 2020 Oct 1.
PMID: 33007200
Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor.
Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, Skiniotis G, Roth BL.
Cell. 2020 Sep 17;182(6):1574-1588.e19. doi: 10.1016/j.cell.2020.08.024.
PMID: 32946782
Plasmonic and Electrostatic Interactions Enable Uniformly Enhanced Liquid Bacterial Surface-Enhanced Raman Scattering (SERS).
Tadesse LF, Ho CS, Chen DH, Arami H, Banaei N, Gambhir SS, Jeffrey SS, Saleh AAE, Dionne J.
Nano Lett. 2020 Oct 14;20(10):7655-7661. doi: 10.1021/acs.nanolett.0c03189. Epub 2020 Oct 4.
PMID: 32914987
High resolution CryoEM structure of the ring-shaped virulence factor EspB from Mycobacterium tuberculosis.
Piton J, Pojer F, Wakatsuki S, Gati C, Cole ST.
J Struct Biol X. 2020 Jul 2;4:100029. doi: 10.1016/j.yjsbx.2020.100029. eCollection 2020.
PMID: 32875288
Structure of human Frizzled5 by fiducial-assisted cryoEM supports a heterodimeric mechanism of canonical Wnt signaling.
Tsutsumi N, Mukherjee S, Waghray D, Janda CY, Jude KM, Miao Y, Burg JS, Aduri NG, Kossiakoff AA, Gati C, Garcia KC.
Structural insights into differences in G protein activation by family A and family B GPCRs.
Hilger D, Kumar KK, Hu H, Pedersen MF, O'Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK.
Science. 2020 Jul 31;369(6503):eaba3373. doi: 10.1126/science.aba3373.
PMID: 32732395
Imaging Arrangements of Discrete Ions at Liquid-Solid Interfaces.
Li HK, Pedro de Souza J, Zhang Z, Martis J, Sendgikoski K, Cumings J, Bazant MZ, Majumdar A.
Nano Lett. 2020 Nov 11;20(11):7927-7932. doi: 10.1021/acs.nanolett.0c02669. Epub 2020 Oct 20.
PMID: 33079557
Structures of metabotropic GABAB receptor.
Papasergi-Scott MM, Robertson MJ, Seven AB, Panova O, Mathiesen JM, Skiniotis G.
Nature. 2020 Aug;584(7820):310-314. doi: 10.1038/s41586-020-2469-4. Epub 2020 Jun 24.
PMID: 32580208
Structural basis of the activation of a metabotropic GABA receptor.
Shaye H, Ishchenko A, Lam JH, Han GW, Xue L, Rondard P, Pin JP, Katritch V, Gati C, Cherezov V.
Nature. 2020 Aug;584(7820):298-303. doi: 10.1038/s41586-020-2408-4. Epub 2020 Jun 17.
PMID: 32555460
Distinct Conformational States Underlie Pausing during Initiation of HIV-1 Reverse Transcription.
Larsen KP, Choi J, Jackson LN, Kappel K, Zhang J, Ha B, Chen DH, Puglisi EV.
J Mol Biol. 2020 Jul 24;432(16):4499-4522. doi: 10.1016/j.jmb.2020.06.003. Epub 2020 Jun 6.
PMID: 32512005
Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex.
Fan M, Zhang J, Tsai CW, Orlando BJ, Rodriguez M, Xu Y, Liao M, Tsai MF, Feng L.
Nature. 2020 Jun;582(7810):129-133. doi: 10.1038/s41586-020-2309-6. Epub 2020 May 20.
PMID: 32494073
Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction.
Kan W, Enos MD, Korkmazhan E, Muennich S, Chen DH, Gammons MV, Vasishtha M, Bienz M, Dunn AR, Skiniotis G, Weis WI.
Elife. 2020 Apr 16;9:e55015. doi: 10.7554/eLife.55015.
PMID: 32297861
Structures of Gα Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms.
Seven AB, Hilger D, Papasergi-Scott MM, Zhang L, Qu Q, Kobilka BK, Tall GG, Skiniotis G.
Cell Rep. 2020 Mar 17;30(11):3699-3709.e6. doi: 10.1016/j.celrep.2020.02.086. Epub 2020 Mar 2.
PMID: 32126208
Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc.
Staus DP, Hu H, Robertson MJ, Kleinhenz ALW, Wingler LM, Capel WD, Latorraca NR, Lefkowitz RJ, Skiniotis G.
Nature. 2020 Mar;579(7798):297-302. doi: 10.1038/s41586-020-1954-0. Epub 2020 Jan 16.
PMID: 31945772
Structure of the neurotensin receptor 1 in complex with β-arrestin 1.
Huang W, Masureel M, Qu Q, Janetzko J, Inoue A, Kato HE, Robertson MJ, Nguyen KC, Glenn JS, Skiniotis G, Kobilka BK.
Nature. 2020 Mar;579(7798):303-308. doi: 10.1038/s41586-020-1953-1. Epub 2020 Jan 16.
PMID: 31945771
A bacterial surface layer protein exploits multistep crystallization for rapid self-assembly.
Herrmann J, Li PN, Jabbarpour F, Chan ACK, Rajkovic I, Matsui T, Shapiro L, Smit J, Weiss TM, Murphy MEP, Wakatsuki S.
Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):388-394. doi: 10.1073/pnas.1909798116. Epub 2019 Dec 17.
PMID: 31848245
Structure and mechanism of the cation-chloride cotransporter NKCC1.
Chew TA, Orlando BJ, Zhang J, Latorraca NR, Wang A, Hollingsworth SA, Chen DH, Dror RO, Liao M, Feng L.
Nature. 2019 Aug;572(7770):488-492. doi: 10.1038/s41586-019-1438-2. Epub 2019 Jul 31.
PMID: 31367042
Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.
Gao Y, Hu H, Ramachandran S, Erickson JW, Cerione RA, Skiniotis G.
Mol Cell. 2019 Aug 22;75(4):781-790.e3. doi: 10.1016/j.molcel.2019.06.007. Epub 2019 Jul 9.
PMID: 31300275
Conformational transitions of a neurotensin receptor 1-Gi1 complex.
Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G.
Nature. 2019 Aug;572(7767):80-85. doi: 10.1038/s41586-019-1337-6. Epub 2019 Jun 26.
PMID: 31243364
Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.
Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK.
Science. 2019 May 10;364(6440):552-557. doi: 10.1126/science.aaw5188.
PMID: 31073061
Structural insights into the activation of metabotropic glutamate receptors.
Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK.
Nature. 2019 Feb;566(7742):79-84. doi: 10.1038/s41586-019-0881-4. Epub 2019 Jan 23.
PMID: 30675062
Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.
Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV, Kobilka BK, Skiniotis G.
Cell. 2019 Jan 24;176(3):448-458.e12. doi: 10.1016/j.cell.2018.11.040. Epub 2019 Jan 10.
PMID: 30639101
Architecture of an HIV-1 reverse transcriptase initiation complex.
Larsen KP, Mathiharan YK, Kappel K, Coey AT, Chen DH, Barrero D, Madigan L, Puglisi JD, Skiniotis G, Puglisi EV.
Nature. 2018 May;557(7703):118-122. doi: 10.1038/s41586-018-0055-9. Epub 2018 Apr 25.
PMID: 29695867
