Jan 30 - Jan 31
2024

Tues - Wed

Day 1 - Opening Remarks

Day 1 - Opening Keynote

Day 1 – Session 1

Day 1 - Session 2

Day 1 – Session 3

Day 2 – Session 4

Day 2 – Session 5

Day 2 - Session 6

Day 2 – Lunch Session

Day 2 – Session 7

Day 2 - Closing Lecture

2024 Alpha/Beta T-Cell/CD19 B-Cell Depleted Haploidentical HSCT International Symposium

α/β T‑cell/CD19 B‑cell depleted haploidentical HSCT carries the hope of making stem cell transplantation safer and more accessible, giving many patients a new chance for a lifesaving cure.

Join leading specialists from around the world to discuss the latest research and clinical breakthroughs related to T-cell depleted HSCT at this two-day, hybrid event held virtually and on the Stanford School of Medicine campus at Paul Berg Hall in the Li Ka Shing Learning and Knowledge Center (LKSC), 291 Campus Drive, Stanford, CA 94043. Our aim is to facilitate intellectual discussion and explore recent advancements in the field, with the hope of paving the way for future research and collaboration.

Our previous symposium attracted over 700 attendees from academia, biotech, pharma, and the non-profit sector. We expect an even wider audience to register and participate this year.

Speakers include:

Selim Corbacioglu, MD, PhD, Regensburg, Bavaria, Germany
Christopher Dvorak, MD, University of California, San Francisco
Rupert Handgretinger, MD, PhD, Children’s University Hospital in Tuebingen, Germany
Peter Lang, MD, PhD, University of Tubingen
Richard O’Reilly, MD, Memorial Sloan Kettering Cancer Center
Michael Allen Pulsipher, MD, University of Utah
Bruno Silva Santos, PhD, University of Lisboa

The symposium is free and registration is now open. Plan to attend in person and join us for a wine and cheese reception after the event to network with fellow physician scientists, meet our sponsors and learn more about their newest technologies.

Agenda

Day 1: January 30, 2024 9:30AM - 5:00PM

Opening Remarks

9:30–9:35 a.m.	Alice Bertaina, MD, PhD, Lorry I. Lokey Professor of Pediatrics, Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Stanford University
9:35–9:45 a.m.	Lloyd B. Minor, MD, Dean, Stanford School of Medicine Paul King, President and CEO, Stanford Medicine Children’s Health

Opening Keynote

9:45–9:50 a.m.	*Introduction of Keynote:* Matthew Porteus, MD, PhD, Sutardja Chuk Professor of Definitive and Curative Medicine; Director, Center for Definitive and Curative Medicine, Stanford University
9:50–10:30 a.m.	Keynote Speaker: Rupert Handgretinger, MD, PhD, Professor Emeritus, Children’s University Hospital Tübingen, Germany Title: The Future of Haploidentical Transplantation in Malignant and Nonmalignant Diseases

Session 1: The Importance of Gamma Delta T cells

Moderator: Irma Airoldi, PhD, Research Scientist, IRCCS Istituto Giannina Gaslini, Genoa, Italy

10:45–11:10 a.m.	Bruno Silva-Santos, PhD, Professor, University of Lisbon Medical School, Portugal Title: Gamma-Delta T Cells for Adoptive Immunotherapy of Leukemias
11:15–11:40 a.m.	Alice Bertaina, MD, PhD, Lorry I. Lokey Professor of Pediatrics, Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Stanford University Title: Exploring the Link: Post-HSCT γδ T-Cells Clonal Expansion and Leukemic Relapse
11:45–12:05 p.m.	Murad Mamedov, PhD, Postdoctoral Fellow, Gladstone Institutes and University of California, San Francisco Title: Genome-Wide CRISPR Screens Decode Cancer Cell Recognition by Gamma-Delta T Cells

Session 2: The Role of Serotherapy in Alpha/Beta T-Cell/CD19 B-Cell Depleted Haploidentical HSCT

Moderator: David Shyr, MD, Clinical Assistant Professor of Pediatrics—Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Stanford University

12:10–12:35 p.m.

Michael Allen Pulsipher, MD, Division Chief of Pediatric Hematology and Oncology, University of Utah
Title: Optimal rATG Exposure in Pediatric Patients Receiving TCRab/CD19 Depleted HaploHSCT Markedly Decreases Relapse, TRM, and Mortality

Lunch Special Session

12:40 - 2:oo PM

1:15–1:35 p.m.	Speaker: Anant Vatsayan, MD, BMT/Cellular Therapy Attending and Assistant Professor, Children’s National Hospital Title: Hospital Resource Utilization in TCR Alpha/Beta/CD19 Depleted Compared to Non-TCell Depleted Hematopoietic Cell Transplant in First 100 Days After Transplant: Single Center Retrospective Study
1:40 - 1:45 p.m.	From our sponsors - Smart Immune: The ProTcell Platform

Session 3: Hemoglobinopathies

Moderator: Tami John, MD, Clinical Associate Professor of Pediatrics, Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Stanford University

2:00–2:25 p.m.	Selim Corbacioglu, MD, PhD, Professor of Pediatrics; Chair of Pediatric Hematology, Oncology, and Stem Cell Transplantation; Children’s Hospital Regensburg, Germany Title: aß T-Cell Depleted Haploidentical HSCT in SCD and TDT
2:30–2:55 p.m.	Josu de la Fuente, PhD, FRCP, Consultant Hematologist, Professor of Practice, Imperial College London Healthcare NHS Trust and Imperial College London, United Kingdom Title: PTCy as a Platform Enabling Universal Transplantation in Haemoglobinopathies
3:00–3:20 p.m.	Round Table Discussion Featuring: Bindu Sathi, MD, Associate Clinical Professor, UCSF Fresno Program, Valley Children’s Hospital Matthew Porteus, MD, PhD, Sutardja Chuk Professor of Definitive and Curative Medicine; Director, Center for Definitive and Curative Medicine, Stanford University

Best Basic Science Abstract

3:25–3:40 p.m.

Irma Airoldi, PhD, Research Scientist, IRCCS Istituto Giannina Gaslini, Genova, Italy
Title: A Novel Advanced Therapy Medicinal Product (ATMP) Composed of Activated Gamma-Delta T Lymphocytes and NK Cells to Counteract Leukemia Relapse in Pediatric Patient Transplanted With Alpha Beta T-Cell/CD19 B-Cell Depleted Haploidentical HSCT

Conclusions of the Day

3:45–4:00 p.m.

Alice Bertaina, MD, PhD, Lorry I. Lokey Professor of Pediatrics, Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Stanford University

Wine & Cheese Networking Social

4:00-5:00 p.m.

Day 2: January 31, 2024 8:30AM - 4:30PM

Welcome

8:3–8:35 a.m.

Tanja Gruber, MD, PhD, Chambers Family Endowed Professor for Pediatric Cancer; Division Chief, Pediatric Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Stanford University

Session 4: Focus on Bone Marrow Failure Syndromes

Moderator: Agnieszka Czechowicz, MD, PhD, Assistant Professor, Pediatrics, Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Stanford University

8:40–9:05 a.m.	Rajni Agarwal, MD, Professor of Pediatrics, Pediatric Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Stanford University Title: ab+ T-cell/CD19+ B-cell depleted HSCT for Fanconi Anemia: Evolution of a Novel Strategy
9:10–9:35 a.m.	Pietro Merli, MD, Department of Pediatric Hematology/Oncology, Cell and Gene Therapy, IRCCS Ospedale, Bambino Gesù Children’s Hospital, Rome, Italy Title: ab T-Cell/CD19 B-Cell Depleted Haploidentical HSCT for Treating BMFs and Myelodysplastic Syndromes
9:40–10:05 a.m.	Amy DeZern, MD, MHS, Professor of Oncology and Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Title: What About Using PT-Cy for Treating Bone Marrow Failure Syndromes?

Session 5: Advances in Leukemias

Moderator: Swati Naik, MBBS, Associate Member, St. Jude Children’s Research Hospital

10:10–10:35 a.m.	Peter Lang, MD, PhD, Professor and Head of Pediatric Stem Cell Transplantation Unit, Children’s University Hospital Tübingen, Germany Title: The Use of aß T-Cell/CD19 B-Cell Depleted Haploidentical Stem Cell Transplantation for Children With Acute Leukemia
10:40–11:05 a.m.	Susan Hiniker, MD, Associate Professor of Radiation Oncology, Radiation Therapy, Stanford University Title: The Role of Total Body Irradiation (TBI) in aß T-Cell/CD19 B-Cell Depleted HSCT Recipients
11:10–11:35 a.m.	Chris Dvorak, MD, Professor and Chief, Division of AI/BMT, University of California, San Francisco Title: Engraftment “Troubles” in aß T-Cell/CD19 B-Cell Depleted HSCT: Process Optimization

Session 6: Immune Reconstitution Post-αβ T-Cell/CD19 B-Cell Depleted Haploidentical HSCT

Moderator: Katja Weinacht, MD, PhD, Assistant Professor of Pediatrics, Stem Cell Transplantation and Regenerative Medicine, Stanford University

11:40–2:05 p.m.	Valentina Bertaina, MSc, Head of Onco-Hematology Flow Cytometry Lab, IRCCS Ospedale, Bambino Gesù Children’s Hospital, Rome, Italy Title: Long-Term Data on Immune Monitoring of Children Given TCR aß/CD19 Cell Depleted HLA-Haploidentical Stem Cell Transplantation (Haplo-HSCT)
12:05–12:30 p.m.	Rosa Bacchetta, MD, Associate Professor of Pediatrics, Stem Cell Transplantation, Stanford University Title: Characterization of Immune Reconstitution in Pediatric and Young Adult Patients with Hematologic Malignancies, Treated With T-allo10 Infusion Post aß Depleted-HSCT

Lunch Special Session

12:30–1:30 p.m.

12:45–1:05 p.m.	Raúl Montiel-Esparza, MD, Attending Physician, Pediatrics Hematology and Oncology, Cure 4 The Kids Foundation, Las Vegas Title: Dissecting Biomarkers of aGvHD in αβ T-Cell/CD19 B-Cell Depleted Haploidentical HSCT
1:10 - 1:15 p.m.	From our sponsor - Smart Immune: The ProTcell Platform

Session 7: Optimizing Manufacturing

Moderator: Gavin Wang, PhD, Director of Development and Manufacturing, Stanford Laboratory for Cell and Gene Medicine, Stanford University

1:30–1:50 p.m.	Nicholas Sukle, Cellular Therapy Facility, Stanford University Title: How to Build a Manufacturing Program From the Ground Up
1:50–2:10 p.m.	Eleni Papanikolaou, PhD, Strategic Lead Hematopoietic Stem Cells, Department of RnD, Miltenyi Biotec, Lecturer of Gene Therapy and Gene Transfer, University of Athens, School of Medicine Title: Troubleshooting the Main Challenges—QC Assays
2:10–2:30 p.m.	James Dinh, Laboratory for Cell and Gene Medicine, Stanford University Title: Is the Prodigy the Future?
2:30–2:45 pm	Group Q&A

Best Clinical Abstract Award

3:00–3:15 p.m.

Larisa Shelikhova, MD, Dmitry Rogachev National Medical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia
Title: TCRαβ+/CD19+Depletion in Hematopoietic Stem Cells Transplantation From Haploidentical Donors in Pediatric Acute Lymphoblastic Leukemia Patients in Complete Remission

Closing Lecture

3:20–3:25 p.m.	Introduction of Keynote: Robertson Parkman, MD, Adjunct Professor, Pediatrics, Stem Cell Transplantation and Regenerative Medicine, Stanford University
3:25–4:15 p.m.	Keynote: Richard O’Reilly, MD, Bone Marrow Transplant Specialist, Claire L. Tow Chair in Pediatric Oncology Research, Memorial Sloan Kettering Cancer Center Title: Banked Third-Party Derived Virus-Specific T-Cells for Infections Following T-Cell Depleted Transplantation

Closing Remarks

4:20–4:30 p.m.

Alice Bertaina, MD, PhD, Lorry I. Lokey Professor of Pediatrics, Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Stanford University

Platinum Sponsor

Miltenyi Biotech

Event Sponsors

Miltenyi Biotec

Neovii

Gamma Biosciences

SmartImmune

Laguna Bio

Medexus Pharma

BioLegend

Find a doctor

Clinics & Services

Research Resources

Professional Training

Education Resources

Jan 30 - Jan 31
2024

Day 1 - Opening Remarks

Day 1 - Opening Keynote

Day 1 – Session 1

Day 1 - Session 2

Day 1 – Session 3

Day 2 – Session 4

Day 2 – Session 5

Day 2 - Session 6

Day 2 – Lunch Session

Day 2 – Session 7

Day 2 - Closing Lecture

2024 Alpha/Beta T-Cell/CD19 B-Cell Depleted Haploidentical HSCT International Symposium

Agenda

Opening Remarks

Opening Keynote

Session 1: The Importance of Gamma Delta T cells

Session 2: The Role of Serotherapy in Alpha/Beta T-Cell/CD19 B-Cell Depleted Haploidentical HSCT

Lunch Special Session

Session 3: Hemoglobinopathies

Best Basic Science Abstract

Conclusions of the Day

Wine & Cheese Networking Social

Welcome

Session 4: Focus on Bone Marrow Failure Syndromes

Session 5: Advances in Leukemias

Session 6: Immune Reconstitution Post-αβ T-Cell/CD19 B-Cell Depleted Haploidentical HSCT

Lunch Special Session

Session 7: Optimizing Manufacturing

Best Clinical Abstract Award

Closing Lecture

Closing Remarks

Platinum Sponsor

Event Sponsors

Jan 30 - Jan 31 2024

Day 1 - Opening Remarks

Day 1 - Opening Keynote

Day 1 – Session 1

Day 1 - Session 2

Day 1 – Session 3

Day 2 – Session 4

Day 2 – Session 5

Day 2 - Session 6

Day 2 – Lunch Session

Day 2 – Session 7

Day 2 - Closing Lecture

2024 Alpha/Beta T-Cell/CD19 B-Cell Depleted Haploidentical HSCT International Symposium

Agenda

Platinum Sponsor

Event Sponsors

Jan 30 - Jan 31
2024