News
April 10, 2024 - Nature
FOXO1 Supercharges CAR-T Cell Therapy
February 28, 2024 – Stanford Cancer Institute
CAR-T Cell Therapy in Solid Tumors
February 21, 2024 – Stanford News
A new RNA editing tool could enhance cancer treatment
February 21, 2024 – Nature News
MEGA-CRISPER tool gives a power boost to cancer-fighting cells
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January 10, 2024 – Spotify
Crystal Mackall Featured in PICI Podcast: From the origins of Immunotherapy to Curing Pediatric Cancers
November 27, 2023 – Society for Immunotherapy of Cancer
SITC Academy of Immuno-Oncology Honors Crystal Mackall as 2023 Fellow
November 27, 2023 – Society for Immunotherapy of Cancer
Alex Doan Receives 2023 SITC Abstract Travel Scholar Award
November 17, 2023 – Stanford Medicine
Katie Freitas Receives the Stanford Immunology Program Hugh McDevitt Award
October 12, 2023 – The Mark Foundation for Cancer Research
Stanford Team Earns the 2023 MArk Foundation Endeavor Award
May 21, 2023 – CSUCI Commencement
Maria del Carmen Arenas Selected to Speak at the 2023 CSUCI Commencement
March 22, 2023 – Alliance for Cancer Gene Therapy
Alliance for Cancer Gene Therapy to honor Dr. Crystal Mackall with Edward Netter Leadership Award
November 29, 2022 – Nature Reviews Drug Discovery
Transcription reprogramming to enhance CAR-T cell function
November 16, 2022 – Stanford Cancer Institute
T cell effector programming is regulated by the Mediatro kinase module
October 25, 2022 – Frankfurter Stiftung für krebskranke Kinder
Johanna Theruvath awarded the 2022 Dr. Maresch-Klingelhöffer
October 18, 2022 – Stanford Cancer Institute
Crystal mackall is elected to the National Academy of Medicine
October 17, 2022 – Twitter
Louai Labanieh is featured in #FacesOfCell
October 4, 2022 – STAT
CAR-T therapy doesn't work in all cancer cases. Scientsts are starting to figure out why.
September 13, 2022 – Stanford Office of Technology Licensing
Unlocking Cell Therapy in Pediatric Diseases: A Conversation with Crystal Mackall
August 30, 2022 – Sarcoma Foundation of America
SFA Honors Crystal L. Mackall with 2022 Nobility in Science Award
July 27, 2022 – Parker Institute for Cancer Immunotherapy
Louai Labanieh is a 2022 Parker Scholar Awardee
June 14, 2022 – S Chronicles
Sabine Heitzeneder receives 2022 Austian Scientists & Scholars in North America award
May 17, 2022 – Stanford Medicine News
'Remote-controlled' CAR-T cell therapy safer, more potent in Stanford mouse studies
April 12, 2022 – P.D. Soros Fellowships for New Americans
Quenton Bubb named Paul & Daisy Soros Fellow
April 9, 2022 – USA TODAY
Revolutionary leukemia treatment offers 'a hopeful moment' in fight against solid tumors
March 22, 2022 - American Association for Cancer Research
Crystal Mackall named Fellow of the AACR Academy
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February 23, 2022 – Accelerating Cancer Immunotherapy Research
GD2-CAR-T cell therapy shows promis against deadly pediatric cancer in early clinical trail
February 7, 2022 - Stanford Medicine Scope
From loss come hope: Pediatric brain tumor treatment shows promiss
December 12, 2021 -- Dr Lori Muffly Spotlights Disparities in Clinical Trial Enrollment, Patient Outcomes in Pediatric ALL
Lori Muffly, MD, associate professor of medicine, Blood & Marrow Transplantation, Stanford University, discusses findings of her study showing disparities in clinical trial enrollment and patient outcomes for at-risk pediatric minority populations with acute lymphoblastic leukemia (ALL).
September 9, 2021 - Stanford Medicine News
Crystal Mackall receives California Institute of Regenerative Medicine grant for CAR T clinical trial
CAR-T cell therapy works for many types of blood cancers, but more than half of patients relapse. A Stanford study provides a clue as to why.
August 2, 2021 - Stanford Medicine News
Study predicts who may benefit from CAR-T cell therapy for blood cancers
CAR-T cell therapy works for many types of blood cancers, but more than half of patients relapse. A Stanford study provides a clue as to why.
June 14, 2021 - Cancer Cell
CAR T cells need a pitstop to win the race
Prolonged TCR-driven stimulation can induce a dysfunctional T cell state, broadly described as T cell exhaustion, limiting the clinical potential of chimeric antigen receptor (CAR) T cells. Recent findings in Science indicate that early cessation of CAR T cell tonic signaling can prevent stabilization of exhaustion-associated epigenetic programs, enabling a prolonged anti-tumor response.
May 8, 2021 -- Crystal Mackall named Pediatric Oncology Award Recipient for Research in Immuno-Oncology
First delivered in 2002, the Pediatric Oncology Award recognizes someone who has demonstrated outstanding leadership or achievement in the field.
May 5, 2021 -- Evading exhaustion to improve CAR-T cell therapy
'Resting' exhausted cancer-fighting immune cells enhances their tumor-killing activity, which may help people with blood and solid cancers.
April 28, 2021 -- Team science award recognizes 8 pediatric cancer researchers at Stanford
Eight Stanford Medicine scientists are among a group of pediatric cancer researchers being honored with the 2021 Team Science Award from the American Association for Cancer Research.
April 8, 2021 -- Crystal Mackall receives AACR-St. Baldrick’s Foundation Award for Outstanding Achievement in Pediatric Cancer Research
Mackall will receive the AACR-St. Baldrick’s Foundation Award for Outstanding Achievement in Pediatric Cancer Research for her pioneering contributions to the fields of pediatric oncology, immunology, and immunotherapeutics, including her discovery of the role of IL-7 in T-cell homeostasis. The award also honors her significant efforts to advance the use of CAR T-cell therapies, and for consistent and ongoing translational research dedicated to establishing novel treatments for pediatric cancer patients.
April 8, 2021 -- St. Baldrick’s Foundation-Stand Up To Cancer Pediatric Cancer Dream Team receives AACR Team Science Award
The St. Baldrick’s Foundation-Stand Up To Cancer Pediatric Cancer Dream Team will receive the AACR Team Science Award for its significant contributions to the pediatric cancer research community, including more than 319 published manuscripts, 44 patent applications, a new clinical trials network, more than $118 million raised to support innovative research, and more than 1,113 children treated in early-phase clinical trials. Many of the children treated in these trials demonstrated durable complete responses.
April 30, 2020 -- New advances toward safely targeting immune cells to pediatric brain tumors
Stanford scientists have taken important steps toward figuring out how to use immune therapy for a group of severe pediatric brain tumors.
December 21, 2019 -- Synthetic Biology Just Keeps on Giving
Overexpression of c-Jun in CAR T cells induces resistance to exhaustion. This story started with an attempt to fix a flawed CAR, and led to the development of a human T cell exhaustion model that shines light into the basic biology of this process and suggests potential approaches to prevent it.
December 4, 2019 -- Stanford researchers program cancer-fighting cells to resist exhaustion, attack solid tumors in mice
CAR-T cells are remarkably effective against blood cancers, but their effect can be transient as the cells become exhausted. Stanford researchers found a way to keep the cells effective in mice with human tumors.
September 17, 2019 -- CureSearch Announces $1.2 Million Grant Supporting New CAR T-cell Therapy for DIPG
CureSearch announces its 2019 Catapult Award has been granted to immunologist Crystal Mackall, MD. This supports her research in CAR T-cell therapy. Co-funded by the Parker Institute for Cancer Immunotherapy (PICI), this $1.2 million award will fund a novel trial examining GD2 CAR T-cell therapy in diffuse intrinsic pontine glioma (DIPG), a highly aggressive brain tumor in children that has a 5-year survival rate of less than 1%.
July 17, 2017 -- Jeffrey and Marieke Rothschild gift establishes Stanford Center for Cancer Cell Therapy
Silicon Valley entrepreneur Jeffrey Rothschild and his wife, Marieke, have provided funding for a new venture at Stanford Medicine to test cancer cell therapies.