December 12, 2021 -- Dr Lori Muffly Spotlights Disparities in Clinical Trial Enrollment, Patient Outcomes in Pediatric ALL
Lori Muffly, MD, associate professor of medicine, Blood & Marrow Transplantation, Stanford University, discusses findings of her study showing disparities in clinical trial enrollment and patient outcomes for at-risk pediatric minority populations with acute lymphoblastic leukemia (ALL).
October 25, 2021 -- Crystal Mackall interviewed on St. Baldrick's Impact Series
The St. Baldrick’s – Stand Up to Cancer Pediatric Cancer Dream Team was the first to harness the power of immunotherapy and genomics to accelerate research for children with cancer.
September 9, 2021 -- Researchers awarded $31 million for clinical trials to treat stroke, heart failure, brain cancer
The California Institute for Regenerative Medicine has awarded $31 million to three Stanford researchers to launch trials of treatments for common diseases. Four other Stanford researchers also received a total of $4.55 million.
August 2, 2021 -- Study predicts who may benefit from CAR-T cell therapy for blood cancers
CAR-T cell therapy works for many types of blood cancers, but more than half of patients relapse. A Stanford study provides a clue as to why.
May 8, 2021 -- Crystal Mackall named Pediatric Oncology Award Recipient for Research in Immuno-Oncology
First delivered in 2002, the Pediatric Oncology Award recognizes someone who has demonstrated outstanding leadership or achievement in the field.
May 5, 2021 -- Evading exhaustion to improve CAR-T cell therapy
'Resting' exhausted cancer-fighting immune cells enhances their tumor-killing activity, which may help people with blood and solid cancers.
April 28, 2021 -- Team science award recognizes 8 pediatric cancer researchers at Stanford
Eight Stanford Medicine scientists are among a group of pediatric cancer researchers being honored with the 2021 Team Science Award from the American Association for Cancer Research.
April 8, 2021 -- Crystal Mackall receives AACR-St. Baldrick’s Foundation Award for Outstanding Achievement in Pediatric Cancer Research
Mackall will receive the AACR-St. Baldrick’s Foundation Award for Outstanding Achievement in Pediatric Cancer Research for her pioneering contributions to the fields of pediatric oncology, immunology, and immunotherapeutics, including her discovery of the role of IL-7 in T-cell homeostasis. The award also honors her significant efforts to advance the use of CAR T-cell therapies, and for consistent and ongoing translational research dedicated to establishing novel treatments for pediatric cancer patients.
April 8, 2021 -- St. Baldrick’s Foundation-Stand Up To Cancer Pediatric Cancer Dream Team receives AACR Team Science Award
The St. Baldrick’s Foundation-Stand Up To Cancer Pediatric Cancer Dream Team will receive the AACR Team Science Award for its significant contributions to the pediatric cancer research community, including more than 319 published manuscripts, 44 patent applications, a new clinical trials network, more than $118 million raised to support innovative research, and more than 1,113 children treated in early-phase clinical trials. Many of the children treated in these trials demonstrated durable complete responses.
April 30, 2020 -- New advances toward safely targeting immune cells to pediatric brain tumors
Stanford scientists have taken important steps toward figuring out how to use immune therapy for a group of severe pediatric brain tumors.
December 21, 2019 -- Synthetic Biology Just Keeps on Giving
Overexpression of c-Jun in CAR T cells induces resistance to exhaustion. This story started with an attempt to fix a flawed CAR, and led to the development of a human T cell exhaustion model that shines light into the basic biology of this process and suggests potential approaches to prevent it.
December 4, 2019 -- Stanford researchers program cancer-fighting cells to resist exhaustion, attack solid tumors in mice
CAR-T cells are remarkably effective against blood cancers, but their effect can be transient as the cells become exhausted. Stanford researchers found a way to keep the cells effective in mice with human tumors.
September 17, 2019 -- CureSearch Announces $1.2 Million Grant Supporting New CAR T-cell Therapy for DIPG
CureSearch announces its 2019 Catapult Award has been granted to immunologist Crystal Mackall, MD. This supports her research in CAR T-cell therapy. Co-funded by the Parker Institute for Cancer Immunotherapy (PICI), this $1.2 million award will fund a novel trial examining GD2 CAR T-cell therapy in diffuse intrinsic pontine glioma (DIPG), a highly aggressive brain tumor in children that has a 5-year survival rate of less than 1%.
July 17, 2017 -- Jeffrey and Marieke Rothschild gift establishes Stanford Center for Cancer Cell Therapy
Silicon Valley entrepreneur Jeffrey Rothschild and his wife, Marieke, have provided funding for a new venture at Stanford Medicine to test cancer cell therapies.
Patient Advocates - A Dream Team Video
August 13, 2020
Patient advocates play a vital role in the St. Baldrick’s – Stand Up To Cancer Pediatric Dream Team. Patient advocates help to put a face on childhood cancer research. They humanize why the research is so critically important as well as translate that incredible work into language that’s more easily understand. Many are parents of kids who have fought cancer and one is a survivor herself. All are working to see the day when no family has to endure what they have.
Proud To Be - A Dream Team Video
August 5, 2020
Researchers and patient advocates are proud to be part of the St. Baldrick’s – Stand Up To Cancer Pediatric Dream Team. Proud to be part of a collaboration to conquer childhood cancers. The work the Dream Team is doing offers hope to children with cancer and their families and we’re closer than ever to finding cures. Not only has the Dream Team propelled ground-breaking cell therapies for blood cancers, it’s also making great progress towards the tougher challenge - helping kids with solid tumors. St. Baldrick’s supporters can be proud of this work that is already saving lives.
What is the Dream Team? -- A Dream Team Video
August 4, 2020
The St. Baldrick’s – Stand Up To Cancer Pediatric Dream Team is doing science differently to cure the incurable. By merging the studies of genomics and immunotherapy, this collaboration of scientists at ten institutions across North America is using children’s own immune systems to treat their tumors. Children are alive today because of this team’s ground-breaking work. St. Baldrick’s is proud to support this innovative research.
Cellular Immunotherapy - Stanford Cancer Institute
March 20, 2019
Cellular immunotherapy is a new way of treating cancer. Cellular immunotherapy is a breakthrough because it's a living therapy; the cells that are administered can last in patients for weeks, months, even years. SCI members Crystal Mackall, MD and David Miklos, MD, PhD opened the first ever clinical trial for a bi-specific (CD19xCD22) CAR-T cell.
The Promise of Cancer Immunotherapy
March 15, 2019
Crystal Mackall, MD, an intentionally recognized expert in cancer immunotherapy, discusses early progress in CAR T-cell therapy and says she’s optimistic that future research will continue to improve patient care.
Cancer Immunotherapy - Big Data in Precision Health
June 21, 2018
Precision Health is a fundamental shift to more proactive and personalized health care that empowers people to lead healthy lives. It is in this spirit of possibility and promise that Stanford Medicine hosted the sixth year of this conference in 2018, bringing together international researchers and leaders from academia, health care, government, and industry to develop actionable steps for improving human health. Crystal Mackall of Stanford spoke on a panel about cancer immunotherapy.