Buckwalter Lab News
Blocking protein curbs memory loss in old mice
Impeding VCAM1, a protein that tethers circulating immune cells to blood vessel walls, enabled old mice to perform as well on memory and learning tests as young mice, a Stanford study found.
Stroke victims with busy immune responses may also see mental declines
How active a person’s immune system is soon after a stroke may be tied to later mental declines, a new study finds.
Post-Stroke Blood Panel Predicts Dementia Within 1 Year
An immune profile in blood drawn 2 days after an ischemic stroke has been shown to predict the likelihood of the loss of mental acuity, 1 year later.
Stanford researchers have found that transient changes in the numbers and activation levels of a handful of circulating immune cell types can predict the likelihood of dementia one year after a stroke.
Researchers like Marion S. Buckwalter, MD, PhD and her colleague Maarten Lansberg, MD, PhD are working on how to prevent dementia in stroke survivors, nearly half of whom develop the condition in the first decade after a stroke. Others are working on new ways to deliver drugs right where they're needed in the brain, developing ways to stimulate the brain's recovery with magnetic fields, and building robotic devices tailored to help individual stroke patients walk more easily. With those and other developments on the horizon, the future for stroke survivors could be bright.
Why is the risk for developing dementia doubled for as much as a decade after stroke? A new study suggests the answer may be B cells.
02/03/15: Study ties immune cells to delayed onset of post-stroke dementia, Stanford Medicine
01/23/15: Brain scientists speak at Davos economic forum, Stanford Medicine
05/04/12 Compound aids stroke recovery, The Stanford Daily
04/25/12 Compound may be able to reverse stroke damage, researchers say, Fox News.com
04/24/12 Study points to potential treatment for stroke, Inside Stanford Medicine
04/24/12 Experimental drug helps the brain recover from stroke -- in mice, Los Angeles Times