Key Takeaways

  • Oligodendrogliomas are tumors that arise within the central nervous system.
  • Headache and seizure are common presenting symptoms.
  • Most oligodendrogliomas occur in people without risk factors.
  • Neurological examination, imaging, and tissue biopsy are the mainstays of glioma diagnosis.
  • Surgical resection, radiation therapy, and chemotherapy are the primary treatment options.

Oligodendrocytes are glial cells that produce myelin, a special coating for neurons that increases the speed at which neurons send signals. They serve as the cell of origin for oligodendroglioma.

Oligodendrogliomas are gliomas of oligodendrocyte origin characterized by both IDH mutations and loss of chromosome 1p and 19q. They comprise about ten percent of glioma tumor diagnoses.

Grade 2 oligodendrogliomas grow more slowly while grade 3 tumors grow more rapidly and can spread within the brain and spinal cord.

Oligodendrogliomas respond better to radiation therapy and chemotherapy than other gliomas.