Key Takeaways

  • Glioblastoma are tumors that arise within the brain or spinal cord.
  • Headache and seizure are common presenting symptoms.
  • Most glioblastomas occur in people without risk factors.
  • Neurological examination, imaging, and tissue biopsy are the mainstays of glioma diagnosis.
  • Surgical resection, radiation therapy, and chemotherapy are the primary treatment options.

Astrocytes are star-shaped glial cells that help maintain the appropriate chemical environment for neuron signaling. They give rise to glioblastomas.

Glioblastoma is a fast-growing and aggressive glioma of astrocyte origin. It does not possess the favorable IDH mutation and is labeled as IDH wildtype. It is the most common aggressive primary brain tumor in adults. Glioblastoma is always considered grade 4.

Glioblastoma can occur in the brain or spinal cord, infiltrating nearby healthy tissue and destroying it. It generally does not spread to distant organs.