Research Projects
Glioma
Gliogene Family Study
Glioma, or brain cancer, is a rare but devastating disease. An international consortium of researchers, led by Dr. Bondy, is working together to learn more about this disease. The current Gliogene study is studying the genetic risk of glioma that can be inherited through families. The aim is to identify which genes are associated with an increased risk of glioma.
If you or someone in your family has brain cancer, we are currently recruiting participants for our Gliogene family study. See eligibility requirements for more information on participating in this study.
Glioma Case-Control Study
We have completed recruitment of over 4,500 glioma cases and controls from 10 centers in and four centers outside of the United States The aim was to learn more about the genetic and environmental factors in brain tumor development. It is the largest study to date on glioma. We are currently analyzing the data and preparing manuscripts. Currently, the study is in its fifth out of the six years of funding by National Cancer Institute.
Breast Cancer
Tumor Characteristics
It is difficult to provide accurate prognoses for ER(-) and early onset breast cancers. Dr. Bondy’s group has developed a new method for this task based on analyzing copy number imbalances, a type of DNA mutation. Understanding the mutations in these types of cancers improves knowledge and predictability for recurrence, distant metastasis, treatment response, and overall survival. This study is funded by National Cancer Institute and Susan G. Komen for the Cure.
Ovarian Cancer
African American Cancer Epidemiology Study (AACES)
This project, also known as Epidemiology of Ovarian Cancer in African American Women, examines environmental and genetic risk factors for ovarian cancer in African American women. The project employs rapid case ascertainment networks in nine states, including Texas, to identify African American women diagnosed with ovarian cancer within 1-3 months of diagnosis. Controls will also be recruited (matched on age, race, state and county). This project is funded by the National Cancer Institute.