The Meyer Lab
The Meyer Lab studies how T-cells and invariant NKT facilitate immune tolerance and graft-versus-leukemia effects in the setting of hematopoietic cell transplantation. Projects involve murine models and human clinical trials. We study murine models of graft-versus-host disease, graft-versus-leukemia and tolerance to pancreatic beta islet. We also study T cell immune reconstitution following transplantation and in graft-versus host disease with emphasis on clinical trial biomonitoring. We specifically focus on:
- The development and application of new tools such as TCR receptor sequencing and T cell Effector Linkage Sequencing to understand alloreactivity and immune tolerance in humans.
- The development of cellular therapy approaches using adoptive transfer of expanded iNKT and T cell populations.
- Investigation of the interaction of iNKT and T cell populations in the induction of immune tolerance in the setting of apoptosis and TIM receptor family signaling.