Acquisition & Reconstruction Methods
In addition to numerous specific application areas, our group spends considerable time developing new MRI techniques that can be applied broadly. These include RF pulse design, MRI pulse sequences, reconstruction algorithms and image analysis tools, as well as "packages" that combine some of these elements.
Relevant Publications
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T2-weighted Imaging of Water, Fat and Silicone
We present a single, clinically feasible MRI sequence that provides robust T2-weighted imaging and water–fat–silicone separation for breast imaging with or without implants.
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Efficient Noise Calculation in Deep Learning-based MRI Reconstructions
We introduce a practical technique to measure voxel-wise noise variance in AI-based MRI reconstructions, addressing a long-standing gap in accelerated MRI.
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Distortion-free water-fat separated diffusion-weighted imaging using spatiotemporal joint reconstruction
We present a novel diffusion-weighted imaging (DWI) technique that addresses two common challenges in standard echo-planar imaging (EPI): geometric distortion and residual fat signals.
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A Framework for Prospective Deployment of Deep Learning in MRI
We broadly categorize the different applications of AI in MRI and provide a framework for important considerations and challenges for prospectively deploying these promising tools in the clinic to enhance patient care.
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Accelerated Multi-Shot DWI Reconstruction Using an Unrolled Network with U-Net as Priors
We accelerate and improve the reconstruction of multi-shot diffusion-weighted MRI by an unrolled pipeline, in which the presumed regularization term is replaced by a U-Net.
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Diagnostic Accuracy of 5-Minute Knee MRI Using AI Image Quality Enhancement
Despite advances in accelerating MRI scans, diagnostic knee MRI protocols typically require upwards of 30 minutes of scanner time, which fundamentally limits patient throughput.
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Multi-Shot DWI Reconstruction with Magnitude-Based Spatial-Angular Locally Low-Rank Regularization
Acquisition of diffusion-weighted images along multiple directions is needed for deriving microstructural metrics from diffusion models, and may also provide valuable information for some clinical applications.
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Utility of Deep Learning Super-Resolution in the Context of Osteoarthritis MRI Biomarkers
Deep learning based super-resolution (SR) is a computer vision method that can enhance the resolution of low-resolution images, which has recently been applied to MRI.
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Optimization of Quantitative Sequences Using Automatic Differentiation of Bloch Simulations
We apply automatic differentiation (widely used in deep learning) and a simple Bloch simulation to efficiently optimize any sequence that can be simulated.
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5-Minute Quantitative Double-Echo in Steady-State Sequence for Comprehensive Whole-Joint Knee MRI
Clinical knee MRI examinations typically utilize 2D imaging methods with thick slices, requiring upwards of 20-25 minutes of scan time, and yet not producing any quantitative information.