Minas presents at Cell Symposium: Exercise Metabolism
Minas Nalbandian attended the 2024 Cell Symposium: Exercise Metabolism conference held in Lisbon, Portugal May 5-7, 2024. The goal of this symposium was to bring together exercise physiologists, systems biologists, circadian biologists, nutrition experts, and others working at the intersection of energy management in health and disease to advance our mechanistic understanding of exercise metabolism in tissues and systems throughout the body, explore the therapeutic benefits of exercise, and integrate these findings with other emerging themes across the metabolic arena.
Topics Covered Included:
- Molecular mechanisms of exercise metabolism
- Integrated omics and the adaptive response to exercise
- Inter-organ communication and signal integration in health and disease
- Exercise effects on age-related diseases and longevity
- Advances from clinical trials of nutrition and exercise
Minas's poster was entitled Inhibition of the gerozyme, 15-PGDH, rescues skeletal muscle overload response in aged mice. Minas and co-authors Elena Monti, Ireh Kim, Peggy Kraft, Kassie Koleckar, Colin Holbrook, and Helen Blau induced muscle overload in young and aged mice through tenotomy. They treated the mice with a small molecule 15-PGDH-inhibitor (SW) or vehicle for 2 weeks. Their data show that regardless of treatment, young mice significantly improved muscle mass and force. By contrast, vehicle-treated aged mice exhibited a reduced muscle mass and force increase. Notably, SW-treated aged mice responded similarly to young mice, exhibiting increased muscle mass and force. Furthermore, single nuclei RNA-sequencing revealed that aged muscles treated with SW had a fiber-type composition resembling young. Their data suggest 15-PGDH inhibition as a potential therapy to restore adaptive muscle responses to overload in aging.
